Examining the Factors Associated With Sexual Violence Against Women in Sierra Leone: A Nationwide Cross-Sectional Study.

In 2019, Sierra Leone declared national emergency over rape and other forms of sexual violence (SV), hence diverting resources from other issues to tackle SV. However, little is known about nationwide risk/protective factors for SV, and this has been a source of critique for the new policy. To fill this gap in knowledge, we investigated the factors for SV toward women using a nationally representative sample. We analyzed the 2013 Demographic and Health Survey (DHS) data, including 16,658 women, aged 15-49 years. The outcome was current SV, defined as being physically forced to have sexual intercourse within the last 12 months. We examined respondent's background, sexual activities, and experience of domestic violence (DV). Logistic regression analyses were performed using STATA/SE v.15.1, accounting for survey design and sample weights. Values of p less than .05 were considered statistically significant. ArcMap was used to demonstrate geographic distribution of SV cases. We found that about 258 (6.3%) women reported SV. In adjusted analysis, women in the north (than south; 2.88, 95% CI = [1.44, 5.75]) and women circumcised between the ages of 1 and 14 (1.67, 95% CI = [1.10, 2.54]) reported higher risk of SV, respectively. Women who had sex more than 25 times per year were 6.9 times more likely to report SV, compared with those with 1 to 24 times (6.91, 95% CI = [1.48, 32.19]). The odds of SV were 6 times higher among women who reported experiencing recent physical violence (5.86, 95% CI = [2.49, 13.80]) or history of SV (6.34, 95% CI = [2.57, 15.65]). In conclusion, this study adds to the literature by providing information on major factors associated with SV toward women in Sierra Leone using a nationally representative sample. Women in the north (Tonkolili), circumcised between the ages of 1 and 14, had sex more than 25 times per year, reported physical violence (12 months before the survey) and SV (ever forced to have sex) reported higher risk for current SV. While more research is needed, these findings will help inform the current emergency operations against SV in Sierra Leone.

Examining the Association Between Racial Bias Exposure and Postpartum Depression Among Women in Wisconsin.

OBJECTIVE: To analyze the association between racial bias and postpartum depression among women in Wisconsin. METHODS: Analyzed the Wisconsin Pregnancy Risk Assessment Monitoring System with a weighted sample of 125,581 women/mothers who delivered a live birth in 2016-2017. The outcome was self-reported postpartum depression. The independent variable was racial bias exposure. Survey-weighted logistic regression analyses were performed adjusting for confounders in 6 models-socioeconomic position, psychosocial factors, health risk behaviors, health care access, stress/obesity, and disease condition. All analyses were completed using STATA accounting for complex survey design and sample weights. RESULTS: In this sample, 6.6% of women/mothers experienced racial bias and 11.5% had postpartum depression. In unadjusted analysis, the odds of postpartum depression were higher for women who experienced racial bias than those who did not (OR 2.15; 95% CI, 1.35-3.41). Non-Hispanic Black women had higher odds for racial bias exposure than other racial/ethnic groups (OR 6.01; 95% CI, 1.69-21.41). However, the relationship between racial bias and postpartum depression was not significant after adjusting for socioeconomic position (OR 1.17; 95% CI, 0.69-1.97), psychosocial factors (OR 1.07; 95% CI, 0.63-1.81), health risk behaviors (OR 0.90; 95% CI, 0.55-1.49], health care access (OR 1.01; 95% CI, 0.60-1.70), stress/obesity (OR 0.73; 95% CI, 0.41-1.30), and disease/morbidity (OR 0.85; 95% CI, 0.46-1.57). DISCUSSION/CONCLUSION: Racial bias was associated with significantly increased risk of postpartum depression. Black women had higher odds for racial bias exposure than other groups. The relationship between racial bias and postpartum depression was not significant after adjusting for confounders, suggesting that social determinants potentially influenced this relationship. These findings should inform screening and health education interventions to minimize racism and poor maternal health outcomes.

Motor vehicle accident is a risk factor for traumatic head injury among children in Abuja: analysis of the first trauma registry in Nigeria.

INTRODUCTION: Pediatric traumatic injury is a major public health concern that is poorly documented in lower and middle-income countries. This study analyzed data on pediatric injuries from a unique hospital trauma registry in Abuja, Nigeria. METHODS: Data were analyzed on 220 traumatically injured patients aged 21 years/less to describe injury characteristics and to determine the association between mechanism of injury and pediatric head injuries in Abuja, Nigeria, between 2014 and 2015. Bivariate analysis using Pearson's chi-square and adjusted logistic regression were conducted to characterize the population and identify risk factors for head injury. P-values<0.05 were considered statistically significant. All statistical analyses were performed using STATA v.15.1. RESULTS: The majority of patients were male (60.9%) with a mean age (SD) of 12.5±6.9 years. Head injuries were most common (49.6%), followed by chest (14.1%), abdomen (12.3%) and back (7.7%). The mechanism of injury was statistically significantly associated with head injury (p=0.027) with 63% of children in a motor vehicle accident sustaining a head injury. After adjusting for covariates, the odds of head injury were 3.8 times higher for children injured in a motor vehicle accidents (MVA) compared to those with falls (95%CI 1.40-10.40). CONCLUSION: This analysis reveals that motor vehicle accident is a risk factor for traumatic head injury among children in Nigeria. Therefore, efforts should be made to address motor vehicle accidents involving children. These data will help to inform age-related prevention and treatment strategies. The results of this study highlight the importance of collecting pediatric trauma data in developing countries.

Setting up a clinical trial for a novel disease: a case study of the Doxycycline for the Treatment of Nodding Syndrome Trial - challenges, enablers and lessons learned.

A large amount of preparation goes into setting up trials. Different challenges and lessons are experienced. Our trial, testing a treatment for nodding syndrome, an acquired neurological disorder of unknown cause affecting thousands of children in Eastern Africa, provides a unique case study. As part of a study to determine the aetiology, understand pathogenesis and develop specific treatment, we set up a clinical trial in a remote district hospital in Uganda. This paper describes our experiences and documents supportive structures (enablers), challenges faced and lessons learned during set-up of the trial. Protocol development started in September 2015 with phased recruitment of a critical study team. The team spent 12 months preparing trial documents, procurement and training on procedures. Potential recruitment sites were pre-visited, and district and local leaders met as key stakeholders. Key enablers were supportive local leadership and investment by the district and Ministry of Health. The main challenges were community fears about nodding syndrome, adverse experiences of the community during previous research and political involvement. Other challenges included the number and delays in protocol approvals and lengthy procurement processes. This hard-to-reach area has frequent power and Internet fluctuations, which may affect cold chains for study samples, communication and data management. These concerns decreased with a pilot community engagement programme. Experiences and lessons learnt can reduce the duration of processes involved in trial-site set-up. A programme of community engagement and local leader involvement may be key to the success of a trial and in reducing community opposition towards participation in research.