RESUMO
The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH). It is most commonly seen after the age of 50 years, with women predominating by three to fourfold. In countries with routine multichannel screening, PHPT is identified earlier and may be asymptomatic. Where biochemical testing is not routine, PHPT is more likely to present with skeletal complications, or nephrolithiasis. Parathyroidectomy (PTx) is indicated for those with symptomatic disease. For asymptomatic patients, recent guidelines have recommended criteria for surgery, however PTx can also be considered in those who do not meet criteria, and prefer surgery. Non-surgical therapies are available when surgery is not appropriate. This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized.
Assuntos
Hiperparatireoidismo Primário/diagnóstico por imagem , Humanos , Hipercalcemia/etiologia , Hiperparatireoidismo Primário/complicações , Hiperparatireoidismo Primário/epidemiologia , Hiperparatireoidismo Primário/terapia , Incidência , Imageamento por Ressonância Magnética/métodos , Nefrolitíase/etiologia , Paratireoidectomia , Prevalência , Cintilografia/métodos , Tomografia Computadorizada por Raios X/métodosRESUMO
Nicotonic acid (NA) infusions are associated with peripheral vasodilation from the generation of vascular prostaglandins with minimal effects on blood pressure (BP) in normotensive subjects. We studied the effects of a NA infusion in 10 hypertensive and 11 normotensive individuals to further characterize systemic hemodynamic responses to NA using pulse waveform analysis. Blood pressure, stroke volume, cardiac output, total peripheral resistance, large and small artery elasticity were determined before and after a 1-h NA infusion. In the normotensives, systolic, diastolic, mean BP, and pulse pressure were not affected by NA. In contrast, the hypertensive subjects experienced a decrease in mean BP from 105 +/- 2 mm Hg to 100 +/- 3 mm Hg (P <.01) accompanied by significant decreases in systolic, diastolic, and pulse pressures. The differential BP response occurred despite comparable increases in heart rate (11% to 13%, P =.05) and similar decreases in total peripheral resistance (6%, P =.05) in both groups. However, the normotensive group demonstrated a decrease in overall vascular compliance, measured as stroke volume to pulse pressure ratio, from 2.12 +/- 0.09 to 1.93 +/- 0.09 mL/mm Hg (P <.05). This finding was supported by a decrease in C1 (large artery compliance), assessed by pulse waveform analysis, from 15.8 +/- 1 to 14.2 +/- 1 mL/mm Hg (P <.05). In contrast, overall compliance and C1 were unchanged after the NA infusion in the hypertensive group. These results suggest that there is a differential hemodynamic response to NA infusion in normotensive and hypertensive individuals. The adjustment in vascular compliance may be an important factor in determining overall BP response to NA.