Elevated drug overdose mortality among Americans who visit Florida, 2003-2020.

OBJECTIVE: Florida state has played a conspicuous role in the current U.S. drug epidemic. Reports suggest that even non-Florida residents may suffer excessive overdose fatalities while visiting the state, possibly in connection to two sets of events: (1) the overprescribing of controlled substances, and more recently, (2) the exploitation of patients' insurance benefits by unscrupulous operators of substance use treatment facilities in Florida. To date, however, no research has examined the overdose fatalities of non-Florida residents inside Florida. METHODS: Death certificate data were used to calculate proportionate mortality ratios for overdoses among Florida residents and visitors. Deaths occurring in the rest of the USA were used as reference populations. RESULTS: Between 2003 and 2020, overdose mortality was slightly elevated for Florida residents within their home counties (106.7 (95% CI 105.8 to 107.5)) and in other Florida counties (113.0 (95% CI 110.0 to 116.0)). Significantly, this mortality was much higher among out-of-state visitors in Florida (163.1 (95% CI 157.5 to 168.8)). When analysed by year, greater overdose mortality among visitors coincided with years when drug prescribing in Florida was rampant, and with the advent of expanded insurance coverage for substance use treatment. During this more recent period (since 2014), overdose mortality was exceptionally high for out-of-state visitors in Palm Beach County, where reports of malpractice in the Florida treatment industry have been concentrated. CONCLUSIONS: Overdose mortality was disproportionately high among out-of-state visitors in Florida. The results suggest that the regulatory policies in Florida may be implicated in drug-related casualties of people who live in other parts of the USA.

Drug Overdose Mortality of Residents and Visitors to Cities.

Background: The ongoing drug epidemic in the United States has shown that there are geographic differences in overdose fatalities. This article introduces a new way to study spatial differences in drug-related mortality, by distinguishing the fatalities of residents and visitors to a region. Methods: Using records of United States deaths from 2001 to 2020, this study examined fatal overdoses among residents and visitors to U.S. metropolitan areas. Results: The findings revealed that the drug fatality levels of residents and visitors differed from one another in many cities. These differences were most pronounced in larger metro areas, where the drug mortality of visitors was disproportionately high. Conclusions: Discussion focuses on implications and possible explanations for these findings, as well as their potential connection to classical conditioning of drug tolerance. More generally, comparing the fatalities of residents and visitors may provide a way to tease apart the roles of person-specific and location-specific contributors to overdose risk.

Living in ancestrally diverse states of the United States is associated with greater vagal tone.

Historically, exposure to dissimilar others ("strangers") was a physiologically arousing event-resulting in avoidance, distrust, and even conflict. Despite this, contemporary migration patterns are increasing intergroup contact. What gives rise to an individual's ability to regulate their arousal such that social engagement with outgroup members is possible? We propose that cultural practices that evolve in ancestrally diverse, compared to ancestrally homogeneous, societies provide more opportunities for society members to engage in emotion regulation. This regulatory exercise, in turn, promotes higher vagal tone-a physiological indicator of one's ability to effectively manage arousal in social interaction. In a secondary analysis of data from the MIDUS 2 Biomarker Project, we find that the ancestral diversity of the states of the United States significantly predicts the average vagal tone of the state's citizens. The findings suggest that social context is associated with predictable and significant adaptations of human physiology over individual lifetimes.

Sexual Chemosignals: Evidence that Men Process Olfactory Signals of Women's Sexual Arousal.

Research suggests that humans can communicate emotional states (e.g., fear, sadness) via chemosignals. However, thus far little is known about whether sexual arousal can also be conveyed through chemosignals and how these signals might influence the receiver. In three experiments, and a subsequent mini meta-analysis, support was found for the hypothesis that men can process the scent of sexually aroused women and that exposure to these sexual chemosignals affect the subsequent perceptions and sexual motivation of men. Specifically, Experiment 1 revealed that men evaluate the axillary sweat of sexually aroused women as more attractive, compared to the scent of the same women when not sexually aroused. In addition, Experiment 2 showed that exposure to sexual chemosignals increased the men's sexual arousal. Experiment 3 found support for the thesis that exposure to sexual chemosignals would increase sexual motivation. As predicted, men devoted greater attention to and showed greater interest in mating with women who displayed sexual cues (e.g., scantily dressed, in seductive poses). By contrast, exposure to the sexual chemosignals did not alter males' attention and mating interest toward women who displayed no sexual cues. It is discussed how sexual chemosignals may function as an additional channel in the communication of sexual interest and how contextual factors can influence the dynamics of human sexual communication.

Population Diversity and Ancestral Diversity As Distinct Contributors to Outgroup Prejudice.

Previous research has shown conflicting findings on how population diversity influences outgroup prejudice. In some cases, prejudice is greater when minority groups make up a larger portion of the population, whereas in other cases, prejudice is lower as diversity increases. This article examined how the diversity of a culture's ancestry-or its historical heterogeneity-would be related to outgroup attitudes. Historically heterogeneous populations descend from ancestors who have migrated from many parts of the world over the past 500 years and, as a result, have a longer legacy of contact with diverse groups of people. The results of two cross-cultural studies found that greater heterogeneity predicted lower levels of outgroup prejudice, and some evidence that diversity in the current population was related to increased prejudice. The findings suggest that intergroup attitudes have deeply entrenched roots that cannot be fully understood by looking at current indicators.

The smell of death: evidence that putrescine elicits threat management mechanisms.

The ability to detect and respond to chemosensory threat cues in the environment plays a vital role in survival across species. However, little is known about which chemical compounds can act as olfactory threat signals in humans. We hypothesized that brief exposure to putrescine, a chemical compound produced by the breakdown of fatty acids in the decaying tissue of dead bodies, can function as a chemosensory warning signal, activating threat management responses (e.g., heightened alertness, fight-or-flight responses). This hypothesis was tested by gaging people's responses to conscious and non-conscious exposure to putrescine. In Experiment 1, putrescine increased vigilance, as measured by a reaction time task. In Experiments 2 and 3, brief exposure to putrescine (vs. ammonia and a scentless control condition) prompted participants to walk away faster from the exposure site. Experiment 3 also showed that putrescine elicited implicit cognitions related to escape and threat. Experiment 4 found that exposure to putrescine, presented here below the threshold of conscious awareness, increased hostility toward an out-group member. Together, the results are the first to indicate that humans can process putrescine as a warning signal that mobilizes protective responses to deal with relevant threats. The implications of these results are briefly discussed.

Cultural differences in the primacy effect for person perception.

Previous work has shown there are robust differences in how North Americans and East Asians form impressions of people. The present research examines whether the tendency to weigh initial information more heavily-the primacy effect-may be another component of these cultural differences. Specifically, we tested whether Americans would be more likely to use first impressions to guide person perception, compared to Japanese participants. In this experiment, participants read a vignette that described a target person's behaviour, then rated the target's personality. Before reading the vignette, some trait information was given to create an expectation about the target's personality. The data revealed that Americans used this initial information to guide their judgments of the target, whereas the Japanese sample based their judgments on all the information more evenly. Thus, Americans showed a stronger primacy effect in their impression formation than Japanese participants, who engaged in more data-driven processing.

Guns, germs, and stealing: exploring the link between infectious disease and crime.

Can variation in crime rates be traced to the threat of infectious disease? Pathogens pose an ongoing challenge to survival, leading humans to adapt defenses to manage this threat. In addition to the biological immune system, humans have psychological and behavioral responses designed to protect against disease. Under persistent disease threat, xenophobia increases and people constrict social interactions to known in-group members. Though these responses reduce disease transmission, they can generate favorable crime conditions in two ways. First, xenophobia reduces inhibitions against harming and exploiting out-group members. Second, segregation into in-group factions erodes people's concern for the welfare of their community and weakens the collective ability to prevent crime. The present study examined the effects of infection incidence on crime rates across the United States. Infection rates predicted violent and property crime more strongly than other crime covariates. Infections also predicted homicides against strangers but not family or acquaintances, supporting the hypothesis that in-group-out-group discrimination was responsible for the infections-crime link. Overall, the results add to evidence that disease threat shapes interpersonal behavior and structural characteristics of groups.

Disentangling the person and the place as explanations for regional differences in suicide.

Identifying whether suicides in a region are due to characteristics of the residents living there or to some enduring feature of the region is difficult when using cross-sectional studies. To distinguish these factors, we compared the suicides of a region's residents with people who were temporarily visiting the region. Using U.S. death records from 1973-2004, we focused on states with the highest and lowest suicide rates over this period. The high suicide region consisted of Arizona, Colorado, Montana, New Mexico, Nevada, Oregon, and Wyoming; the low suicide region consisted of Connecticut, Illinois, Massachusetts, New Jersey, and New York. For each region, we considered three groups of decedents: residents who died inside the region, residents who died outside the region, and visitors to the region. Proportionate mortality ratios were calculated for all suicides and separately for firearm suicides. In the high suicide region, visitors to and residents away from the region both had elevated suicide levels, to about the same extent as residents dying inside the region. Therefore, short-term exposure to the region and being a resident of the region each predicted suicide. In the low suicide region, the suicides of residents at home were reduced, but their suicides rose dramatically once they left the area. There was no decrease in suicides among visitors to the region. Firearm use was related to the suicide levels of each region. Overall, the results suggest that both the available means to commit suicide and the contextual features of the regions contributed to their extreme suicides. We discuss how an examination of visitors can help researchers generate novel inferences about the causes of suicide.

Exposure to the US Stroke Buckle as a risk factor for cerebrovascular mortality.

BACKGROUND: For decades, the Stroke Buckle region in the southeastern USA has had a high incidence of deaths from cerebrovascular disease relative to the rest of the country. We test here the possibility that temporary exposure to the Stroke Buckle can explain some of the excessive stroke mortality there. METHODS: We examined all US death records between 1979 and 1988, noting whether individuals died inside or outside the 153-county Stroke Buckle in the coastal plains of North Carolina, South Carolina and Georgia. We also noted the decedents' county of residence, which was coded separately. Proportionate mortality ratios (PMRs) were used to assess the risk of dying of a stroke. RESULTS: Stroke Buckle residents who died in their home county were at an increased risk of dying of a stroke (PMR = 130.2; 95% confidence interval, CI = 128.9-131.6; p < 0.0001). Visitors to the Buckle were also at an increased risk of dying of a stroke (PMR = 111.9; 95% CI = 107.5-116.2; p < 0.0001), and Buckle residents who died while outside of the region were less likely to die of a stroke (PMR = 89.9; 95% CI = 86.2-93.6; p < 0.0001). CONCLUSIONS: These results show that even short-term exposure to the Stroke Buckle accounts for some of the elevation in stroke deaths there.

Stereotyping, self-affirmation, and the cerebral hemispheres.

The authors used the processing characteristics of the left and right cerebral hemispheres to gain some insight into the relation between self-affirmation and stereotyping. In Study 1, self-affirmation led to greater stereotyping (of a librarian) and to greater left hemisphere activation, which in turn mediated the self-affirmation/stereotyping relationship. Study 2 replicated these results but also found that self-affirmation decreased stereotyping for a stigmatized target. However, relative hemisphere activation did not mediate this self-affirmation/stereotyping relationship. These studies showed that self-affirmation can either increase or decrease stereotyping depending on the status of the target and that relative hemisphere activation may provide clues as to underlying processes of stereotyping. In both studies, relative hemisphere activation was assessed using a line bisection task. Discussion focuses on possible mechanisms of different kinds of stereotyping and on the ways in which a consideration of relative hemisphere activation could help researchers gain insights into those mechanisms.