RESUMO
The authors showed stabilizing effect of rhenium binuclear cluster compounds with organic ligands on erythrocytic membranes. Estimation of functional condition of cells was studied by a chemical fragility method. Biphase type of rhenium complexes concentration curves stabilization has been found out; the influence of organic radicals and axial substructures (Cl- and Br-) on degree of stabilization has been showed. Different mechanisms of interaction of the investigated complexes with erythrocytic are suggested.
Assuntos
Ácidos/farmacologia , Eritrócitos/efeitos dos fármacos , Rênio/farmacologia , Humanos , LigantesRESUMO
Conductivity of bilayered lipid membrane (BLM) for the ions of alkali metals under action of binuclear rhenium complex (V) [Re2(Ph3P)2 (AHK)2O3Cl4] has been analyzed. It is found that BLM conductivity sharply increases in presence of lithium ions, then it drops and slowly increases again up to maximum value which is not changed. If sodium, rubidium and caesium chlorides are used as electrolytes the BLM conductivity almost does not change. The mechanisms of change of BLM conductivity is suggested for the ions of alkali metals under interaction with binuclear complex of rhenium.
Assuntos
Bicamadas Lipídicas/química , Rênio/química , Césio/química , Cloretos/química , Transporte de Íons , Permeabilidade , Rubídio/química , Cloreto de Sódio/químicaRESUMO
Under influence of a binuclear complex compound [Re2(Ph3P)2(ANA)2O3Cl4] a sharp increase (on 2-3 ranges) of conductivity of bilayer lipid membranes (BLM) was found. Then it slowly decreased to some stable level. Similar properties were earlier discovered among some detergents of polyethylene ether nature. A supposition is made about structure rebuilding in BLM, that had place between detergents and lipid molecules of cell membranes.