[Oxytocin genetic pathway (CD38) and SDQ psychosocial characteristics in adolescent schoolchildren]. / Geneticheskii put' oksitotsina (CD38) i psikhosotsial'nye kharakteristiki po oprosniku SDQ u shkol'nikov-podrostkov.

OBJECTIVE: To determine an effect of CD38 on the regulation of oxytocin (OT) production and to identify psychosocial characteristics according to the Strength and Difficulties Questionnaire (SDQ) in adolescent schoolchildren. MATERIAL AND METHODS: The study included 308 adolescents, aged 11-18 years, of an unbiased school sample from three large cities of Central Siberia (Krasnoyarsk, n=194; Abakan, n=76; Kyzyl, n=38). All participants were Russian. The ethnicity was determined by mother's descent. Psychological study using SDQ and analysis of gene polymorphisms in DNA from saliva samples were carried out. Genotyping was performed using TaqMan allele discrimination technology with TaqMan probes (DNA synthesis, Russia) using real-time polymerase chain reaction and Rotor-Gene 6000 (Corbett Life Science, Australia). Data were analyzed using Statistica v.10 software. RESULTS: In adolescence, the high activity of the OT pathway can cause a number of negative effects, such as emotional instability («Emotional problems¼ (p=0.048), «Goodman total score¼ (p=0.057), «Hyperactivity¼ (p=0.075). The differences are statistically significant (p≤0.05)) in young (11-14 years old) adolescent girls who carry the A allele for rs3796863 polymorphism. Similar gender differences are characteristic and have been described for other populations. The distribution of the CD38 rs3796863 genotypes was similar to that in Caucasians. In adolescence, OT production decreases in comparison with the prepubertal period, and there are gender differences in its concentration in biological liquids towards an increase in girls compared to boys. In addition, the medians of individual SDQ scales differed significantly between boys and girls in our sample. CONCLUSION: Our results support the hypothesis of excessive social sensitivity mediated by OT, which may lead to some gender- and age-dependent psychosocial problems.

[The relationship between internet addiction and sleep disorders in adolescents of Central Siberia in different types of consumed content]. / Vzaimosvyaz' internet-zavisimosti i narushenii sna u podrostkov Tsentral'noi Sibiri pri raznykh vidakh potreblyaemogo kontenta.

OBJECTIVE: To establish the relationship between disturbances of the regime and quality of night sleep and daytime sleepiness in adolescents from Central Siberia with internet addiction with different types of content consumed. MATERIAL AND METHODS: A single cross-sectional observational study of a school sample in three large cities in Siberia was performed. The study included 4615 schoolchildren aged 12-18 years (46.2% boys and 53.8% girls, average age 14.58±0.02 years). To identify Internet addiction and its types the following tests were used: the Chen scale (CIAS), adapted by V.L. Malygin and K.A. Feklisov; Russian-language versions of the Game Addiction Scale for Adolescents and the Social Media Disorder Scale. Questions from the Pittsburgh Sleep Quality Index (PSQI) were used to assess nighttime sleep. Daytime sleepiness was assessed by the Pediatric Daytime Sleepiness Scale (PDSS). RESULTS: Adolescents with Internet addiction are characterized by late going to bed (p<0.001), late awakening (p=0.016), a decrease in the duration of night sleep (p=0.004), an increase in the time to fall asleep and frequent nighttime awakenings (p=0.017), and more pronounced daytime sleepiness (p<0.001). CONCLUSION: Internet-addicted adolescents are characterized by significant disturbances in the quality of night sleep, which requires appropriate psychological and pedagogical correction.

[The prevalence and mental comorbidity of internet-dependent behavior in adolescents of Central Siberia]. / Rasprostranennost' i psikhicheskaya komorbidnost' internet-zavisimogo povedeniya u podrostkov Tsentral'noi Sibiri.

OBJECTIVE: To study the prevalence of Internet addiction (IA) in adolescents in Central Siberia and the association of IA with mental health problems. MATERIAL AND METHODS: The study included 2950 adolescents (44.7% boys and 54.3% girls), aged 11-18 years (mean age 14.5±1.3). Younger adolescents (11-14 years old) accounted for 52.4%, senior ones (15-18 years old) did 47.6%. The Chen scale (CIAS) with a cutoff level of 65 points was used to evaluate IA. The overall CIAS value of 27-42 points was regarded to be adaptive Internet use (AIU); 43-64 points being non-adaptive Internet use (NIU); 65 points and above were considered to be IA. Mental health was assessed using SDQ, which includes five scales: 1) prosocial behavior; 2) emotional symptoms; 3) behavior problems; 4) hyperactivity; 5) peer problems. RESULTS: The prevalence of AIU is 50.3% (55.9% among boys and 45.6% among girls, p<0.01), NIU was found in 42.9% (38.9/46.3%, p<0.001), IA occurred in 6.8% (5.1/8.2%, p<0.001). The prevalence of IA among adolescents, aged 11-14 years old, was 5.9%, between the ages of 15-18 it was 7.8% (p=0.04). In the AIU group, emotional symptom** were observed in 5.1% of adolescents, behavior problems in 6.1%, hyperactivity in 3.6%; in the NIU group - in 14.9%, 11.7% and 9.4% of adolescents; in the IA group, there were 34%, 24% and 26% of adolescents, respectively. In terms of odds ratio (OR), the greatest effect size was observed for hyperactivity (OR=5.23, p<0.001) and emotional disorders (OR=4.85, p<0001). CONCLUSIONS: The prevalence of IA is 6.8%. IA is more common in girls and increases with age. IA is associated with mental health problems, the greatest effect size is observed for hyperactivity and emotional disorders. The incidence of psychopathological manifestations increases depending on the degree of impairment in network behavior.