1.
Biochemistry (Mosc)
; 81(9): 941-50, 2016 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27682166
RESUMO
Fibrillarin is one of the most studied nucleolar proteins. Its main functions are methylation and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course of evolution from archaea to eukaryotes, it acquired an additional N-terminal glycine and arginine-rich (GAR) domain. In this review, we discuss the evolution of fibrillarin structure and its relation to the functions of the protein in prokaryotes and eukaryotes.