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Objective To discuss the hemodynamic features of internal carotid aneurysm,and study the relationship between hemodynamics and occurrence,development and rupture of internal carotid aneurysm .Methods The 3D model of internal carotid aneurysm was established by materialise's interactive medical image control system(MIMICS).The finite element analysis software ANSYS was used to carry out numerical simulation.Results Low wall shear stress of internal carotid aneurysms were located at the same area.The wall shear stress at different region were positive correlation with the blood flow velocity.Conclusion The blood flow velocity and wall shear stress at the top of aneurysm are relatively low.This position is consistent with the rupture position.The significant changes of hemodynamic at the top of aneurysm may trigger a series of mechanical biological effects on the internal carotid aneurysm wall.The changes alters cells'gene and protein's expression,causes rupture of the aneurysm.
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Objective: To evaluate the anti-aging, anti-fatigue, and anti-coldness effects of Queen Bee Larva (QBL) Methods: 1. American filth flies were divided into control group, QBL groups fed with 5%, 10%, 20%, 40% QBL and D-galactose groups, and the average and the highest life-span were recorded. 2. NIH mice were divided into control group, QBL groups fed with 1/3, 1/6 QBL, and the anti-fatigue, anti-coldness, anti-stress capacities and skin hydroxyproline were detected. Results: The average life-span of the male flies was longer in the 5%～20% QBL fed groups and in the 40% QBL with D-galactose fed group than in the others; The anti-fatigue effect was significantly higher in the mice of 1/3 QBL fed than in the others; The skin hydroxyproline was significantly higher in the male mice fed QBL than that in the control. The decrease of body temperature in cold condition was lower in the mice fed QBL than that in the control. Conclusion: QBL has distinct life-prolonging and anti-aging effects in male filth flies and delay skin-aging, and improve the anti-fatigue and anti-coldness capacity in mice.
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Objective: To investigate the effect of Plantago asiatica L. on antioxidation in rats. Methods: The antioxidative enzymes and LPO of serum, heart, and liver tissues were determined. Results: The activities of superoxide (SOD) in serum and heart were significantly lower than that of the control. The lipid peroxide (LPO) level in serum and heart was markedly higher than that of the control. Serum and liver catalase (CAT) activities in rats fed with high fat were decreased. Activities of liver glutathione peroxidase (GSH Px) in high fat rats were decreased significantly. The production of SOD activities in serum and liver and GSH Px in liver were increased significantly in rats maintained on Plantago asiatica L. supplemented diets, meanwhile serum and heart LPO were reduced. Conclusion: 15g/kg Plantago asiatica L. can increase the antioxidation against lipid peroxide in hyperlipidemic rats.
