Dynamics of cognitive anomalies in patients with first episodes of juvenile endogenous psychosis.

The therapeutic dynamics of neuropsychological and neurophysiological markers of impairments to cognitive functions were studied in groups of patients with first episodes of juvenile endogenous psychosis (90 patients). At the initial stage of remission, subjects were found to show improvements in processes associated with voluntary regulation of cognitive functions (due to the activity of extensive networks of cortical and subcortical structures), while more automatic processes (associated mainly with the temporal areas of the brain) remained abnormal. Changes in neurocognitive anomalies during the onset of remission were also identified in groups of patients in whom episodes had different syndromal structures - catatonic, hallucinatory-delusional, and affective-delusional.

[The dynamics of neurocognitive functions in patients with the first psychotic episode of endogenous psychosis manifested in the juvenile age].

The dynamics of neuropsychological and neurophysiological markers of cognitive functions was analyzed in the groups of the first-episode young male patients. Totally 90 patients have been studied. At the early stage of remission, the improvement of the processes associated with voluntary regulation of cognition caused by the activity of the wide circuit of cortical and subcortical structures was found. At the same time, the more automated processes related mostly with the temporal brain areas remained abnormal. The peculiarities of neurocognitive dynamics during the development of the remission were revealed in the groups of patients with different syndrome structure of the first episode (catatonic, delusion/hallucination, affective-delusion).