Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative.

BACKGROUND: Global collaboration in cardio-oncology is needed to understand the prevalence of cancer therapy-related cardiovascular toxicity in different risk groups, practice settings, and geographic locations. There are limited data on the socioeconomic and racial/ethnic disparities that may impact access to care and outcomes. To address these gaps, we established the Global Cardio-Oncology Registry, a multinational, multicenter prospective registry. METHODS: We assembled cardiologists and oncologists from academic and community settings to collaborate in the first Global Cardio-Oncology Registry. Subsequently, a survey for site resources, demographics, and intention to participate was conducted. We designed an online data platform to facilitate this global initiative. RESULTS: A total of 119 sites responded to an online questionnaire on their practices and main goals of the registry: 49 US sites from 23 states and 70 international sites from 5 continents indicated a willingness to participate in the Global Cardio-Oncology Registry. Sites were more commonly led by cardiologists (85/119; 72%) and were more often university/teaching (81/119; 68%) than community based (38/119; 32%). The average number of cardio-oncology patients treated per month was 80 per site. The top 3 Global Cardio-Oncology Registry priorities in cardio-oncology care were breast cancer, hematologic malignancies, and patients treated with immune checkpoint inhibitors. Executive and scientific committees and specific committees were established. A pilot phase for breast cancer using Research Electronic Data Capture Cloud platform recently started patient enrollment. CONCLUSIONS: We present the structure for a global collaboration. Information derived from the Global Cardio-Oncology Registry will help understand the risk factors impacting cancer therapy-related cardiovascular toxicity in different geographic locations and therefore contribute to reduce access gaps in cardio-oncology care. Risk calculators will be prospectively derived and validated.

Analysis of exosome-derived microRNAs as early biomarkers of lipopolysaccharide-induced acute kidney injury in rats.

Sepsis contributes to the high prevalence of acute kidney injury (AKI), which mainly occurs in hospitalized patients. The delay in AKI detection is a risk factor for death and chronicity; thus, early diagnosis is essential for initiating proper treatment strategies. Although serum creatinine is used as biomarker, it is increased in plasma serum creatinine only at late stages of AKI. MicroRNAs (miRNAs), a class of noncoding RNAs responsible for gene regulation, can be found in biological fluids within vesicles such as exosomes and may be promising tools for the early detection of AKI. We aimed to identify potential blood miRNAs that can be used as early biomarkers of sepsis-induced AKI in rats. Adult male Wistar rats received a single dose of lipopolysaccharide (LPS). The earliest significant increase in serum creatinine was detected 4 h after LPS administration. To evaluate whether miRNAs could act as early biomarkers, blood samples were collected before and 2 h after LPS infusion. Serum NGAL levels were used as a comparative marker. Serum miRNAs were derived from exosomes, and their expression were evaluated by the PCR array. miR-181a-5p and miR-23b-3p showed higher expression in LPS-treated rats than in the control animals (p < 0.05). Bioinformatics analysis showed that both miRNAs target molecules associated with transcription factors that regulate genes related to proinflammatory cytokines. Considering that LPS activates transcription factors that lead to the production of proinflammatory cytokines, possible premature changes in the serum levels of miR-181a-5p and miR-23b-3p may be used to identify sepsis-induced AKI earlier.

[Initiation and consumption of psychoactive substances among adolescents and young adults in an Anti-Drug Psychosocial Care Center]. / Iniciação e consumo de substâncias psicoativas entre adolescentes e adultos jovens de Centro de Atenção Psicossocial Antidrogas/CAPS-AD.

The study seeks to characterize the initiation and consumption pattern of psychoactive substances among adolescents and young adults enrolled in an Alcohol and Drug Psychosocial Care Center (CAPS-AD). This study was conducted with records of attendance and the consumption pattern was classified in accordance with WHO: infrequent use (lifetime use, per year or up to five days per month); frequent use (6 to 19 times in the past 30 days); heavy use (≥ 20 times in the last 30 days). In the age group comparison, the test for proportion and association analysis was used and the prevalence and prevalence ratio was calculated with a significance level of 5% and 95% confidence interval. Of the total of adolescents and young adults treated between 2003 and 2008 (475), most were male, single, poorly educated, live with relations and have psychic symptoms. Statistical significance was found for age at initiation of use: adolescents compared to young adults started earlier (≤ 14 years): tobacco, marijuana, cocaine, crack and other SPA consumption. Among adolescents, significant results were found for the less frequent consumption of tobacco, more frequent use of alcohol, and heavy consumption of marijuana. These findings may contribute to the preventive and therapeutic CAPS-AD programs.

Iniciação e consumo de substâncias psicoativas entre adolescentes e adultos jovens de Centro de Atenção Psicossocial Antidrogas/CAPS-AD / Initiation and consumption of psychoactive substances among adolescents and young adults in an Anti-Drug Psychosocial Care Center

O estudo tem como objetivo caracterizar a iniciação e o padrão de consumo de substâncias psicoativas, entre adolescentes e adultos jovens matriculados em Centro de Atenção Psicossocial Álcool e Drogas - CAPS AD. Foram utilizados os registros dos atendimentos, sendo o padrão de consumo classificado segundo a OMS: uso pouco frequente (uso na vida, no ano ou no mês até cinco dias); uso frequente (de seis até 19 vezes nos últimos 30 dias); uso pesado (> 20 vezes nos últimos 30 dias); na comparação das faixas etárias utilizou-se teste de proporções e para análise das associações, calculou-se prevalência/P e razão de prevalência/RP, com significância de 5% e intervalo de confiança 95%. No total de adolescentes e jovens atendidos entre 2003 e 2008 (475), a maioria foi masculina, solteira, com baixa escolaridade, coabitando com pais e sintomas psíquicos. Constatou-se significância estatística para idade de iniciação ao consumo: adolescentes, em relação aos jovens iniciaram mais precocemente (< 14 anos): o consumo de tabaco; maconha, cocaína; crack e outras SPA. Entre adolescentes, verificou-se resultados significantes para consumo menos frequente de tabaco; mais frequente de álcool; e consumo pesado de maconha. Esses achados podem contribuir para programas preventivos e terapêuticos do CAPS-AD.

The study seeks to characterize the initiation and consumption pattern of psychoactive substances among adolescents and young adults enrolled in an Alcohol and Drug Psychosocial Care Center (CAPS-AD). This study was conducted with records of attendance and the consumption pattern was classified in accordance with WHO: infrequent use (lifetime use, per year or up to five days per month); frequent use (6 to 19 times in the past 30 days); heavy use (> 20 times in the last 30 days). In the age group comparison, the test for proportion and association analysis was used and the prevalence and prevalence ratio was calculated with a significance level of 5% and 95% confidence interval. Of the total of adolescents and young adults treated between 2003 and 2008 (475), most were male, single, poorly educated, live with relations and have psychic symptoms. Statistical significance was found for age at initiation of use: adolescents compared to young adults started earlier (< 14 years): tobacco, marijuana, cocaine, crack and other SPA consumption. Among adolescents, significant results were found for the less frequent consumption of tobacco, more frequent use of alcohol, and heavy consumption of marijuana. These findings may contribute to the preventive and therapeutic CAPS-AD programs.

O vínculo entre usuários e equipes em duas unidades de saúde da família em um município no estado do Rio de Janeiro / The link between users and staff in two family health units in a city of the state of Rio de Janeiro

Um dos pilares da Estratégia Saúde da Família é o estabelecimento de vínculos, criação de laços de compromisso e co-responsabilidade entre profissionais de saúde e a população. O vínculo refere um relacionamento estreito de confiança. O principal objetivo do presente estudo foi avaliar o vínculo entre usuários e equipes em duas unidades de Saúde da Família, com diferentes modelos de estrutura e organização, em um Município do Estado do Rio de Janeiro. O procedimento metodológico constituiu-se de uma abordagem qualitativa, estudo tipo exploratório-descritivo, com analise de conteúdo temática. Os temas do estudo, identificados como indicadores de vínculo, organizados no roteiro de entrevistas, apresentou as principais categorias de análise: - Serviço de saúde que a família busca; profissional de saúde que procura quando se sente mal; conhecimento dos profissionais da equipe da Estratégia Saúde da Família; dificuldades para atendimentos na Estratégia; satisfação com atendimento que recebe na Estratégia Saúde da Família; participação em atividades coletivas nas Unidades de Saúde da Família. Identificamos nas duas Unidades várias fragilidades, referentes ao vínculo entre os usuários e as equipes de saúde da família. Em relação à Unidade mista, que funciona com um centro de especialidades médicas, podemos destacar que a procura inicial por profissionais especialistas em uma Unidade de Saúde da Família, para atendimento das demandas de saúde, aponta uma maior dificuldade para formação de vínculo.

One of the pillars of the Family Health Strategy is the establishment of links, creating bonds of commitment and co-responsibility between health professionals and the public. This bond refers to a close relationship of trust. The main objective of this study was to evaluate the link between users and staff in two Family Health units, with different structural and organizational models, in a municipality in the State of Rio de Janeiro. The methodological procedure consisted of a qualitative approach, an exploratory descriptive study, using thematic analysis of content. The topics of the study, identified as indicators of bonds, arranged in the interview scripts, presented the main categories of analysis: - The health service that the family seeks; the health professional consulted when feeling ill; professional staff knowledge within the Family Health Strategy; problems with being attended within the Strategy; satisfaction with the care received in the Family Health Strategy; participation in collective activities in the Family Health Units. We identified several weaknesses in the two units, concerning the link between users and family health teams. Regarding the mixed Clinic that operates with a core of medical specialties, we note that the initial outreach for professional specialists in a Family Health Unit, to meet health needs, indicates a major difficulty in forming links.