Diffuse leptomeningeal glioneuronal tumor in an 8-year-old girl: case report and review of the literature.

Diffuse leptomeningeal glioneuronal tumors (DLGNTs) are rare central nervous system tumors of childhood that were recently described as a new entity. DLGNTs usually manifest with symptoms related to increased intracranial pressure or spinal cord compression. The classic radiological feature is a widespread leptomeningeal enhancement that may involve the entire neuroaxis. Microscopic examination demonstrates oligodendroglial-like cells that are positive for OLIG2, MAP2, and S100 and negative for IDH-1. Anaplastic features occur in some cases. Molecularly, DLGNTs are characterized by chromosome arm 1p deletion and alteration of a mitogen-activated protein kinase (MAPK) pathway gene, most commonly BRAF-KIAA1549 fusion. There is no established grading system for these tumors, which may have an indolent or aggressive behavior. Treatment usually involves chemotherapy and radiation therapy.

Frequência e características maternas e do recém nascido associadas à internação de neonatos em UTI no município de Joinville, Santa Catarina - 2012 / The frequency and characteristics of mothers and newborns associated with the admission of neonates to ICU in the municipality of Joinville, Santa Catarina - 2012

Determinar a frequência e os fatores associados à internação de recém-nascidos em UTI neonatal no município de Joinville, Santa Catarina. Métodos: estudo transversal com base nos registros de nascidos vivos (DNV) e de internações em Unidades de Terapia Intensivas (UTI) neonatais em 2012. Para avaliar associações entre variáveis explicativas e desfecho foram estimados odds ratios (OR) brutos e ajustados e respectivos intervalos de confiança de 95 por cento com a técnica de regressão logística. Resultados: a frequência de internação em UTI neonatal foi de 11,7 por cento (9,69-13,7). Baixo peso ao nascer (ORaj = 8,1 [6,3 - 10,3]), malformação congênita (ORaj = 6,0 [3,2 – 11,2]), Apgar de 5º minuto < 7 (ORaj = 5,7 [2,6 - 12,3]), prematuridade (ORaj = 3,4 [(2,7 – 4,1]), sexo masculino (ORaj = 1,5 [1,2 - 1,8]), hospital público (ORaj = 2,0 [1,6 - 2,4]), mãe sem companheiro (ORaj = 1,4 [1,2 - 1,7]), baixa escolaridade materna (ORaj = 1,4 [1,2 - 1,7]) e < 7 consultas no pré natal (ORaj = 1,3[1,1 - 1,6]) constituíram fatores de risco para internação. Conclusões: as características biológicas dos recém-nascidos associadas à internação em UTI neonatal são passíveis de prevenção, evidenciando a importância da qualificação da assistência à gestante e recém-nascido...

To determine the frequency of and factors associated with the admission of newborns to neonatal ICU in the municipality of Joinville, Santa Catarina. Methods: a cross-sectional study was conducted based on the records of live births (DNV) and admissions to neonatal intensive care units (NICUs) in 2012. To evaluate associations between the explanatory variables and the outcome, the crude and adjusted odds ratios (OR) were calculated with respective confidence intervals of 95 percent using the logistic regression technique. Results: the frequency of admission to NICU was 11.7 percent (9.69-13.7). Low birth weight (ORadj = 8.1 [6.3 – 10.3]), congenital deformity (ORadj = 6.0 [3.2 – 11.2]), a 5th minute Apgar score < 7 (ORadj = 5.7 [2.6 – 12.3]), prematurity (ORadj = 3.4 [(2.7 – 4.1]), male sex (ORaj = 1.5 [1.2 – 1.8]), public hospital (ORadj = 2.0 [1;6 – 2.4]), single mother (ORadj = 1.4 [1.2 – 1.7]), low level of education of mother (ORadj = 1.4 [1.2 – 1.7]) and < 7 prenatal consults (ORadj = 1.3[1.1 – 1.6]) were found to be risk factors for admission. Conclusions: the biological characteristics of the newborns associated with admission to neonatal intensive care units are susceptible to prevention, thereby demonstrating the importance of improving care for pregnant women and newborns...