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Neuroimmunomodulation ; 22(4): 250-5, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25322841

RESUMO

BACKGROUND: Burning mouth syndrome (BMS) is a chronic disorder defined as a burning sensation in the oral mucosa without evidence of pathological findings. Its pathophysiology is largely unknown, but psychiatric disorders and personality traits have been implicated. OBJECTIVE: This study investigated whether there is any association between salivary biomarkers and personality traits in BMS patients. METHODS: It was a cross-sectional, controlled study that evaluated 30 individuals with BMS and 32 controls. All subjects were assessed with a structured psychiatric interview (Mini International Neuropsychiatric Interview) and the Big Five inventory. Salivary levels of brain-derived neurotrophic factor (BDNF), neural growth factor, tumor necrosis factor-α, interleukin (IL)-6, IL-10 and cortisol were determined. RESULTS: We found that BMS patients exhibited more traits of neuroticism and lower openness than controls. Openness showed a moderate and negative correlation with cortisol, BDNF and IL-6. CONCLUSION: Personality traits are associated with salivary biomarkers in BMS.


Assuntos
Transtornos de Ansiedade/fisiopatologia , Síndrome da Ardência Bucal/metabolismo , Personalidade/fisiologia , Estresse Psicológico/metabolismo , Idoso , Biomarcadores/metabolismo , Fator Neurotrófico Derivado do Encéfalo/metabolismo , Síndrome da Ardência Bucal/fisiopatologia , Estudos Transversais , Feminino , Humanos , Hidrocortisona/metabolismo , Interleucina-10/metabolismo , Interleucina-6/metabolismo , Masculino , Pessoa de Meia-Idade , Fator de Crescimento Neural/metabolismo , Neuroticismo , Saliva/química , Estresse Psicológico/fisiopatologia , Fator de Necrose Tumoral alfa/metabolismo
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