Enhanced perceptual selection of predicted stimulus orientations following statistical learning.

Perception is influenced by predictions about the sensory environment. These predictions are informed by past experience and can be shaped by exposure to recurring patterns of sensory stimulation. Predictions can enhance perception of a predicted stimulus, but they can also suppress it by favoring novel and unexpected sensory information that is inconsistent with the predictions. Here we employed statistical learning to assess the effects of exposure to consistent sequences of oriented gratings on subsequent visual perceptual selection, as measured with binocular rivalry. Following statistical learning, the first portion of a learned sequence of stimulus orientations was presented to both eyes, followed by simultaneous presentation of the next grating in the sequence to one eye and an orthogonal unexpected orientation to the other eye. We found that subjects were more likely to perceive the grating that matched the orientation that was consistent with the predictive context. That is, observers were more likely to see what they expected to see, compared to the likelihood of perceiving the unexpected stimulus. Some other studies in the literature have reported the opposite effect of prediction on visual perceptual selection, and we suggest that these inconsistencies may be due to differences across studies in the level of the visual processing hierarchy at which competing perceptual interpretations are resolved.

Effects of involuntary and voluntary attention on critical spacing of visual crowding.

Visual spatial attention can be allocated in two distinct ways: one that is voluntarily directed to behaviorally relevant locations in the world, and one that is involuntarily captured by salient external stimuli. Precueing spatial attention has been shown to improve perceptual performance on a number of visual tasks. However, the effects of spatial attention on visual crowding, defined as the reduction in the ability to identify target objects in clutter, are far less clear. In this study, we used an anticueing paradigm to separately measure the effects of involuntary and voluntary spatial attention on a crowding task. Each trial began with a brief peripheral cue that predicted that the crowded target would appear on the opposite side of the screen 80% of the time and on the same side of the screen 20% of the time. Subjects performed an orientation discrimination task on a target Gabor patch that was flanked by other similar Gabor patches with independent random orientations. For trials with a short stimulus onset asynchrony between cue and target, involuntary capture of attention led to faster response times and smaller critical spacing when the target appeared on the cue side. For trials with a long stimulus onset asynchrony, voluntary allocation of attention led to faster reaction times but no significant effect on critical spacing when the target appeared on the opposite side to the cue. We additionally found that the magnitudes of these cueing effects of involuntary and voluntary attention were not strongly correlated across subjects for either reaction time or critical spacing.

Visual cortical γ-aminobutyric acid and perceptual suppression in amblyopia.

In amblyopia, abnormal visual experience during development leads to an enduring loss of visual acuity in adulthood. Physiological studies in animal models suggest that intracortical GABAergic inhibition may mediate visual deficits in amblyopia. To better understand the relationship between visual cortical γ-aminobutyric acid (GABA) and perceptual suppression in persons with amblyopia (PWA), we employed magnetic resonance spectroscopy (MRS) to quantify GABA levels in both PWA and normally-sighted persons (NSP). In the same individuals, we obtained psychophysical measures of perceptual suppression for a variety of ocular configurations. In PWA, we found a robust negative correlation between the depth of amblyopia (the difference in visual acuity between the amblyopic and non-amblyopic eyes) and GABA concentration that was specific to visual cortex and was not observed in a sensorimotor cortical control region. Moreover, lower levels of visual cortical GABA were associated with weaker perceptual suppression of the fellow eye by the amblyopic eye and stronger suppression of the amblyopic eye by the fellow eye. Taken together, our findings provide evidence that intracortical GABAergic inhibition is an important component of the pathology of human amblyopia and suggest possible therapeutic interventions to restore vision in the amblyopic eye through enhancement of visual cortical GABAergic signaling in PWA.

Transfer of Perceptual Learning From Local Stereopsis to Global Stereopsis in Adults With Amblyopia: A Preliminary Study.

It has long been debated whether the analysis of global and local stereoscopic depth is performed by a single system or by separate systems. Global stereopsis requires the visual system to solve a complex binocular matching problem to obtain a coherent percept of depth. In contrast, local stereopsis requires only a simple matching of similar image features. In this preliminary study, we recruited five adults with amblyopia who lacked global stereopsis and trained them on a computerized local stereopsis depth task for an average of 12 h. Three out of five (60%) participants recovered fine global stereoscopic vision through training. Those who recovered global stereopsis reached a learning plateau more quickly on the local stereopsis task, and they tended to start the training with better initial local stereopsis performance, to improve more on local stereopsis with training, and to have less severe amblyopia. The transfer of learning from local stereopsis to global stereopsis is compatible with an interacting two-stage model.

Spatial Attention Enhances Crowded Stimulus Encoding Across Modeled Receptive Fields by Increasing Redundancy of Feature Representations.

Any visual system, biological or artificial, must make a trade-off between the number of units used to represent the visual environment and the spatial resolution of the sampling array. Humans and some other animals are able to allocate attention to spatial locations to reconfigure the sampling array of receptive fields (RFs), thereby enhancing the spatial resolution of representations without changing the overall number of sampling units. Here, we examine how representations of visual features in a fully convolutional neural network interact and interfere with each other in an eccentricity-dependent RF pooling array and how these interactions are influenced by dynamic changes in spatial resolution across the array. We study these feature interactions within the framework of visual crowding, a well-characterized perceptual phenomenon in which target objects in the visual periphery that are easily identified in isolation are much more difficult to identify when flanked by similar nearby objects. By separately simulating effects of spatial attention on RF size and on the density of the pooling array, we demonstrate that the increase in RF density due to attention is more beneficial than changes in RF size for enhancing target classification for crowded stimuli. Furthermore, by varying target/flanker spacing, as well as the spatial extent of attention, we find that feature redundancy across RFs has more influence on target classification than the fidelity of the feature representations themselves. Based on these findings, we propose a candidate mechanism by which spatial attention relieves visual crowding through enhanced feature redundancy that is mostly due to increased RF density.

Transient cholinergic enhancement does not significantly affect either the magnitude or selectivity of perceptual learning of visual texture discrimination.

Perceptual learning (PL), often characterized by improvements in perceptual performance with training that are specific to the stimulus conditions used during training, exemplifies experience-dependent cortical plasticity. An improved understanding of how neuromodulatory systems shape PL promises to provide new insights into the mechanisms of plasticity, and by extension how PL can be generated and applied most efficiently. Previous studies have reported enhanced PL in human subjects following administration of drugs that increase signaling through acetylcholine (ACh) receptors, and physiological evidence indicates that ACh sharpens neuronal selectivity, suggesting that this neuromodulator supports PL and its stimulus specificity. Here we explored the effects of enhancing endogenous cholinergic signaling during PL of a visual texture discrimination task. We found that training on this task in the lower visual field yielded significant behavioral improvement at the trained location. However, a single dose of the cholinesterase inhibitor donepezil, administered before training, did not significantly impact either the magnitude or the location specificity of texture discrimination learning compared with placebo. We discuss potential explanations for discrepant findings in the literature regarding the role of ACh in visual PL, including possible differences in plasticity mechanisms in the dorsal and ventral cortical processing streams.

Sequential perceptual learning of letter identification and "uncrowding" in normal peripheral vision: Effects of task, training order, and cholinergic enhancement.

Human adults with normal vision are capable of improving performance on visual tasks through repeated practice. Previous work has shown that enhancing synaptic levels of acetylcholine (ACh) in healthy human adults with donepezil (trade name: Aricept) can increase the magnitude and specificity of perceptual learning (PL) for motion direction discrimination in the perifovea. In the current study, we ask whether increasing the synaptic levels of ACh in healthy human adults with donepezil boosts learning of low-contrast isolated letter identification and high-contrast flanked letter identification in normal peripheral vision. Two groups of observers performed sequential training over multiple days while ingesting donepezil. One group trained on isolated low-contrast letters in Phase 1 and crowded high-contrast letters in Phase 2, and the other group performed the reverse sequence, thereby enabling us to differentiate possible effects of drug and training order on PL of letter identification. All testing and training were performed monocularly in peripheral vision, at an eccentricity of 10 degrees along the lower vertical meridian. Our experimental design allowed us to evaluate the effects of sequential training and to ask whether increasing cholinergic signaling boosted learning and/or transfer of low-contrast isolated letter identification and high-contrast flanked letter identification in normal peripheral vision. We found that both groups improved on each of the two tasks. However, our results revealed an effect of training task order on flanked letter identification: Observers who trained on isolated targets first showed rapid early improvement in flanked letter identification but little to no additional improvement after 30 training blocks, while observers who first trained with flanked letters improved gradually on flanked letter identification over the entire 100-block course of training. In addition, we found no effect of donepezil on PL of either isolated or flanked letter identification. In other words, donepezil neither boosted nor blocked learning to identify isolated low-contrast letters or learning to uncrowd in normal peripheral vision.

Slow Endogenous Fluctuations in Cortical fMRI Signals Correlate with Reduced Performance in a Visual Detection Task and Are Suppressed by Spatial Attention.

Spatial attention improves performance on visual tasks, increases neural responses to attended stimuli, and reduces correlated noise in visual cortical neurons. In addition to being visually responsive, many retinotopic visual cortical areas exhibit very slow (<0.1 Hz) endogenous fluctuations in functional magnetic resonance imaging signals. To test whether these fluctuations degrade stimulus representations, thereby impairing visual detection, we recorded functional magnetic resonance imaging responses while human participants performed a target detection task that required them to allocate spatial attention to either a rotating wedge stimulus or a central fixation point. We then measured the effects of spatial attention on response amplitude at the frequency of wedge rotation and on the amplitude of endogenous fluctuations at nonstimulus frequencies. We found that, in addition to enhancing stimulus-evoked responses, attending to the wedge also suppressed slow endogenous fluctuations that were unrelated to the visual stimulus in topographically defined areas in early visual cortex, posterior parietal cortex, and lateral occipital cortex, but not in a nonvisual cortical control region. Moreover, attentional enhancement of response amplitude and suppression of endogenous fluctuations were dissociable across cortical areas and across time. Finally, we found that the amplitude of the stimulus-evoked response was not correlated with a perceptual measure of visual target detection. Instead, perceptual performance was accounted for by the amount of suppression of slow endogenous fluctuations. Our results indicate that the amplitude of slow fluctuations of cortical activity is influenced by spatial attention and suggest that these endogenous fluctuations may impair perceptual processing in topographically organized visual cortical areas.

Cognitive Neuroscience: Functional Specialization in Human Cerebellum.

A new brain imaging study reveals that the human cerebellum contains a region that represents visual space that is dissociable from a region displaying visual memory-related activity, with both regions exhibiting precise functional coupling with corresponding cerebral cortical areas.

Recent cross-modal statistical learning influences visual perceptual selection.

Incoming sensory signals are often ambiguous and consistent with multiple perceptual interpretations. Information from one sensory modality can help to resolve ambiguity in another modality, but the mechanisms by which multisensory associations come to influence the contents of conscious perception are unclear. We asked whether and how novel statistical information about the coupling between sounds and images influences the early stages of awareness of visual stimuli. We exposed subjects to consistent, arbitrary pairings of sounds and images and then measured the impact of this recent passive statistical learning on subjects' initial conscious perception of a stimulus by employing binocular rivalry, a phenomenon in which incompatible images presented separately to the two eyes result in a perceptual alternation between the two images. On each trial of the rivalry test, subjects were presented with a pair of rivalrous images (one of which had been consistently paired with a specific sound during exposure while the other had not) and an accompanying sound. We found that, at the onset of binocular rivalry, an image was significantly more likely to be perceived, and was perceived for a longer duration, when it was presented with its paired sound than when presented with other sounds. Our results indicate that recently acquired multisensory information helps resolve sensory ambiguity, and they demonstrate that statistical learning is a fast, flexible mechanism that facilitates this process.

Perceptual learning induces changes in early and late visual evoked potentials.

Studies of visual cortical responses following visual perceptual learning (VPL) have produced diverse results, revealing neural changes in early and/or higher-level visual cortex as well as changes in regions responsible for higher cognitive processes such as attentional control. In this study, we investigated substrates of VPL in the human brain by recording visual evoked potentials with high-density electroencephalography (hdEEG) before (Session 1) and after (Session 2) training on a texture discrimination task (TDT), with two full nights of sleep between sessions. We studied the following event-related potential (ERP) components: C1 (early sensory processing), P1 and N1 (later sensory processing, modulated by top-down spatial attention), and P3 (cognitive processing). Our results showed a significant decrease in C1 amplitude at Session 2 relative to Session 1 that was positively correlated with the magnitude of improvement in behavioral performance. Although we observed no significant changes in P1 amplitude with VPL, both N1 amplitude and latency were significantly decreased in Session 2. Moreover, the difference in N1 latency between Session 1 and Session 2 was negatively correlated with behavioral improvement. We also found a significant increase in P3 amplitude following training. Our results suggest that VPL of the TDT task may be due to plasticity in early visual cortical areas as well as changes in top-down attentional control and cognitive processing.

Neither Cholinergic Nor Dopaminergic Enhancement Improve Spatial Working Memory Precision in Humans.

Acetylcholine and dopamine are neurotransmitters that play multiple important roles in perception and cognition. Pharmacological cholinergic enhancement reduces excitatory receptive field size of neurons in marmoset primary visual cortex and sharpens the spatial tuning of visual perception and visual cortical fMRI responses in humans. Moreover, previous studies show that manipulation of cholinergic or dopaminergic signaling alters the spatial tuning of macaque prefrontal cortical neurons during the delay period of a spatial working memory (SWM) task and can improve SWM performance in macaque monkeys and human subjects. Here, we investigated the effects of systemic cholinergic and dopaminergic enhancement on the precision of SWM, as measured behaviorally in human subjects. Cholinergic transmission was increased by oral administration of 5 mg of the cholinesterase inhibitor donepezil, and dopaminergic signaling was enhanced with 100 mg levodopa/10 mg carbidopa. Each neurotransmitter system was separately investigated in double-blind placebo-controlled studies. On each trial of the SWM task, a square was presented for 150 ms at a random location along an invisible circle with a radius of 12 degrees of visual angle, followed by a 900 ms delay period with no stimulus shown on the screen. Then, the square was presented at new location, displaced in either a clockwise (CW) or counterclockwise (CCW) direction along the circle. Subjects used their memory of the location of the original square to report the direction of displacement. SWM precision was defined as the amount of displacement corresponding to 75% correct performance. We observed no significant effect on SWM precision for either donepezil or levodopa/carbidopa. There was also no significant effect on performance on the SWM task (percent correct across all trials) for either donepezil or levodopa/carbidopa. Thus, despite evidence that acetylcholine and dopamine regulate spatial tuning of individual neurons and can improve performance of SWM tasks, pharmacological enhancement of signaling of these neurotransmitters does not substantially affect a behavioral measure of the precision of SWM in humans.

Donepezil Does Not Enhance Perceptual Learning in Adults with Amblyopia: A Pilot Study.

Amblyopia is a developmental disorder that results in a wide range of visual deficits. One proven approach to recovering vision in adults with amblyopia is perceptual learning (PL). Recent evidence suggests that neuromodulators can enhance adult plasticity. In this pilot study, we asked whether donepezil, a cholinesterase inhibitor, enhances visual PL in adults with amblyopia. Nine adults with amblyopia were first trained on a low-contrast single-letter identification task while taking a daily dose (5 mg) of donepezil throughout training. Following 10,000 trials of training, participants showed improved contrast sensitivity for identifying single letters. However, the magnitude of improvement was no greater than, and the rate of improvement was slower than, that obtained in a previous study in which six adults with amblyopia were trained using an identical task and protocol but without donepezil (Chung et al., 2012). In addition, we measured transfer of learning effects to other tasks and found that for donepezil, the post-pre performance ratios in both a size-limited (acuity) and a spacing-limited (crowding) task were not significantly different from those found in the previous study without donepezil administration. After an interval of several weeks, six participants returned for a second course of training on identifying flanked (crowded) letters, again with concurrent donepezil administration. Although this task has previously been shown to be highly amenable to PL in adults with amblyopia (Chung et al., 2012; Hussain et al., 2012), only one observer in our study showed significant learning over 10,000 trials of training. Auxiliary experiments showed that the lack of a learning effect on this task during donepezil administration was not due to either the order of training of the two tasks or the use of a sequential training paradigm. Our results reveal that cholinergic enhancement with donepezil during training does not improve or speed up PL of single-letter identification in adults with amblyopia, and importantly, it may even halt learning and transfer related to a crowding task. Clinical Trial Registration: This study was registered with ClinicalTrials.gov (NCT03109314).

Relative Spatial Frequency Processing Drives Hemispheric Asymmetry in Conscious Awareness.

Visual stimuli with different spatial frequencies (SFs) are processed asymmetrically in the two cerebral hemispheres. Specifically, low SFs are processed relatively more efficiently in the right hemisphere than the left hemisphere, whereas high SFs show the opposite pattern. In this study, we ask whether these differences between the two hemispheres reflect a low-level division that is based on absolute SF values or a flexible comparison of the SFs in the visual environment at any given time. In a recent study, we showed that conscious awareness of SF information (i.e., visual perceptual selection from multiple SFs simultaneously present in the environment) differs between the two hemispheres. Building upon that result, here we employed binocular rivalry to test whether this hemispheric asymmetry is due to absolute or relative SF processing. In each trial, participants viewed a pair of rivalrous orthogonal gratings of different SFs, presented either to the left or right of central fixation, and continuously reported which grating they perceived. We found that the hemispheric asymmetry in perception is significantly influenced by relative processing of the SFs of the simultaneously presented stimuli. For example, when a medium SF grating and a higher SF grating were presented as a rivalry pair, subjects were more likely to report that they initially perceived the medium SF grating when the rivalry pair was presented in the left visual hemifield (right hemisphere), compared to the right hemifield. However, this same medium SF grating, when it was paired in rivalry with a lower SF grating, was more likely to be perceptually selected when it was in the right visual hemifield (left hemisphere). Thus, the visual system's classification of a given SF as "low" or "high" (and therefore, which hemisphere preferentially processes that SF) depends on the other SFs that are present, demonstrating that relative SF processing contributes to hemispheric differences in visual perceptual selection.

Cholinergic, But Not Dopaminergic or Noradrenergic, Enhancement Sharpens Visual Spatial Perception in Humans.

The neuromodulator acetylcholine modulates spatial integration in visual cortex by altering the balance of inputs that generate neuronal receptive fields. These cholinergic effects may provide a neurobiological mechanism underlying the modulation of visual representations by visual spatial attention. However, the consequences of cholinergic enhancement on visuospatial perception in humans are unknown. We conducted two experiments to test whether enhancing cholinergic signaling selectively alters perceptual measures of visuospatial interactions in human subjects. In Experiment 1, a double-blind placebo-controlled pharmacology study, we measured how flanking distractors influenced detection of a small contrast decrement of a peripheral target, as a function of target-flanker distance. We found that cholinergic enhancement with the cholinesterase inhibitor donepezil improved target detection, and modeling suggested that this was mainly due to a narrowing of the extent of facilitatory perceptual spatial interactions. In Experiment 2, we tested whether these effects were selective to the cholinergic system or would also be observed following enhancements of related neuromodulators dopamine or norepinephrine. Unlike cholinergic enhancement, dopamine (bromocriptine) and norepinephrine (guanfacine) manipulations did not improve performance or systematically alter the spatial profile of perceptual interactions between targets and distractors. These findings reveal mechanisms by which cholinergic signaling influences visual spatial interactions in perception and improves processing of a visual target among distractors, effects that are notably similar to those of spatial selective attention.SIGNIFICANCE STATEMENT Acetylcholine influences how visual cortical neurons integrate signals across space, perhaps providing a neurobiological mechanism for the effects of visual selective attention. However, the influence of cholinergic enhancement on visuospatial perception remains unknown. Here we demonstrate that cholinergic enhancement improves detection of a target flanked by distractors, consistent with sharpened visuospatial perceptual representations. Furthermore, whereas most pharmacological studies focus on a single neurotransmitter, many neuromodulators can have related effects on cognition and perception. Thus, we also demonstrate that enhancing noradrenergic and dopaminergic systems does not systematically improve visuospatial perception or alter its tuning. Our results link visuospatial tuning effects of acetylcholine at the neuronal and perceptual levels and provide insights into the connection between cholinergic signaling and visual attention.

Perceptual suppression of predicted natural images.

Perception is shaped not only by current sensory inputs but also by expectations generated from past sensory experience. Humans viewing ambiguous stimuli in a stable visual environment are generally more likely to see the perceptual interpretation that matches their expectations, but it is less clear how expectations affect perception when the environment is changing predictably. We used statistical learning to teach observers arbitrary sequences of natural images and employed binocular rivalry to measure perceptual selection as a function of predictive context. In contrast to previous demonstrations of preferential selection of predicted images for conscious awareness, we found that recently acquired sequence predictions biased perceptual selection toward unexpected natural images and image categories. These perceptual biases were not associated with explicit recall of the learned image sequences. Our results show that exposure to arbitrary sequential structure in the environment impacts subsequent visual perceptual selection and awareness. Specifically, for natural image sequences, the visual system prioritizes what is surprising, or statistically informative, over what is expected, or statistically likely.

Spatial distortions in localization and midline estimation in hemianopia and normal vision.

Studies have shown that individuals with hemianopia tend to bisect a line toward their blind, contralesional visual field, termed the hemianopic line bisection error (HLBE). One theory proposes that the HLBE is a perceptual distortion resulting from expansion of the central region of visual space. If true, perceptual expansions of the central regions in the intact hemifield should also be present and observable across different tasks. We tested this hypothesis using a peripheral localization task to assess localization and midpoint estimation along the horizontal axis of the visual field. In this task, participants judged the location of a target dot presented inside a Goldmann perimeter relative to their perceived visual field boundary. In Experiment 1, we tested neurologically healthy participants on the peripheral localization task as well as a novel midpoint assessment task in which participants reported their perceived midpoint along the horizontal axis of their left and right visual fields. The results revealed consistency in individual biases across the two tasks. We then used the peripheral localization task to test whether two patients with hemianopia showed a selective expansion of central visual space. For these patients, three axes were tested: the spared temporal horizontal axis and the upper and lower vertical axes. The results support the notion that the HLBE is due to expansion of perceived space along the spared temporal axis. Together, the results of both experiments validate the use of these novel paradigms for exploring perceptual asymmetries in both healthy individuals and patients with visual field loss.

Individual differences in visual field shape modulate the effects of attention on the lower visual field advantage in crowding.

It has previously been reported that visual crowding of a target by flankers is stronger in the upper visual field than in the lower, and this finding has been attributed to greater attentional resolution in the lower hemifield (He, Cavanagh, & Intriligator, 1996). Here we show that the upper/lower asymmetry in visual crowding can be explained by natural variations in the borders of each individual's visual field. Specifically, asymmetry in crowding along the vertical meridian can be almost entirely accounted for by replacing the conventional definition of visual field location, in units of degrees of visual angle, with a definition based on the ratio of the extents of an individual's upper and lower visual field. We also show that the upper/lower crowding asymmetry is eliminated when stimulus eccentricity is expressed in units of percentage of visual field extent but is present when the conventional measure of visual angle is used. We further demonstrate that the relationship between visual field extent and perceptual asymmetry is most evident when participants are able to focus their attention on the target location. These results reveal important influences of visual field boundaries on visual perception, even for visual field locations far from those boundaries.

Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis.

BACKGROUND: The magnitude, consistency, and manner of association between sedentary time and outcomes independent of physical activity remain unclear. PURPOSE: To quantify the association between sedentary time and hospitalizations, all-cause mortality, cardiovascular disease, diabetes, and cancer in adults independent of physical activity. DATA SOURCES: English-language studies in MEDLINE, PubMed, EMBASE, CINAHL, Cochrane Library, Web of Knowledge, and Google Scholar databases were searched through August 2014 with hand-searching of in-text citations and no publication date limitations. STUDY SELECTION: Studies assessing sedentary behavior in adults, adjusted for physical activity and correlated to at least 1 outcome. DATA EXTRACTION: Two independent reviewers performed data abstraction and quality assessment, and a third reviewer resolved inconsistencies. DATA SYNTHESIS: Forty-seven articles met our eligibility criteria. Meta-analyses were performed on outcomes for cardiovascular disease and diabetes (14 studies), cancer (14 studies), and all-cause mortality (13 studies). Prospective cohort designs were used in all but 3 studies; sedentary times were quantified using self-report in all but 1 study. Significant hazard ratio (HR) associations were found with all-cause mortality (HR, 1.240 [95% CI, 1.090 to 1.410]), cardiovascular disease mortality (HR, 1.179 [CI, 1.106 to 1.257]), cardiovascular disease incidence (HR, 1.143 [CI, 1.002 to 1.729]), cancer mortality (HR, 1.173 [CI, 1.108 to 1.242]), cancer incidence (HR, 1.130 [CI, 1.053 to 1.213]), and type 2 diabetes incidence (HR, 1.910 [CI, 1.642 to 2.222]). Hazard ratios associated with sedentary time and outcomes were generally more pronounced at lower levels of physical activity than at higher levels. LIMITATION: There was marked heterogeneity in research designs and the assessment of sedentary time and physical activity. CONCLUSION: Prolonged sedentary time was independently associated with deleterious health outcomes regardless of physical activity. PRIMARY FUNDING SOURCE: None.

Hemisphere-dependent attentional modulation of human parietal visual field representations.

Posterior parietal cortex contains several areas defined by topographically organized maps of the contralateral visual field. However, recent studies suggest that ipsilateral stimuli can elicit larger responses in the right than left hemisphere within these areas, depending on task demands. Here we determined the effects of spatial attention on the set of visual field locations (the population receptive field [pRF]) that evoked a response for each voxel in human topographic parietal cortex. A two-dimensional Gaussian was used to model the pRF in each voxel, and we measured the effects of attention on not only the center (preferred visual field location) but also the size (visual field extent) of the pRF. In both hemispheres, larger pRFs were associated with attending to the mapping stimulus compared with attending to a central fixation point. In the left hemisphere, attending to the stimulus also resulted in more peripheral preferred locations of contralateral representations, compared with attending fixation. These effects of attention on both pRF size and preferred location preserved contralateral representations in the left hemisphere. In contrast, attentional modulation of pRF size but not preferred location significantly increased representation of the ipsilateral (right) visual hemifield in right parietal cortex. Thus, attention effects in topographic parietal cortex exhibit hemispheric asymmetries similar to those seen in hemispatial neglect. Our findings suggest potential mechanisms underlying the behavioral deficits associated with this disorder.