Philadelphia-positive B-lymphoblastic leukemia in a middle-income country - A real-world multicenter cohort.

Outside of clinical trials, few studies have addressed the outcomes of Ph+ acute lymphoblastic leukemia (ALL) in adults, especially from developing world. In this study, we conducted a multicenter analysis on the outcomes of patients aged > 15 years with Ph+ ALL, aiming to get to know an overview of the Brazilian experience as well as to explore baseline factors associated with relapse and mortality in our setting. Over these 10 years, patients were treated with diverse protocols, all of them always combined with a frontline tyrosine-kinase inhibitor. A total of 123 Ph+ ALL patients was included. Imatinib was the first line TKI in 97 %. The complete response rate was 79 %. The early death rate was 15 %, being associated with increasing age at diagnosis (p = 0.06). The use of intensive versus attenuated induction regimen was not associated with higher induction mortality (p = 0.99). Overall, 29 % of patients aged ≤ 60 years underwent allogeneic transplantation, 87 % in first CR. 4-year overall survival (OS) and relapse-free survival were 25 % and 24 %, respectively. The incidence of relapse (death as a competitor) was 29 %, while the non-relapse mortality was 42 %. Only age was independently associated with OS, and lactate dehydrogenase level and central nervous disease at diagnosis were related to relapse in our cohort. This is the first historical cohort multicenter study on Ph+ ALL from Brazil. Reporting these outcomes is essential to encourage public policies to expand access to new drugs and transplantation in middle-income countries.

Prenatal exposure to cigarette smoke causes persistent changes in the oxidative balance and in DNA structural integrity in rats submitted to the animal model of schizophrenia.

Epidemiological studies have indicated that prenatal exposure to environmental insults can bring an increased risk of schizophrenia. The objective of our study was to determine biochemical parameters in rats exposed to cigarette smoke (CS) in the prenatal period, evaluated in adult offspring submitted to animal model of schizophrenia induced by acute subanaesthetic doses of ketamine (5 mg/kg, 15 mg/kg and 25 mg/kg). Pregnant female Wistar rats were exposed to 12 commercially filtered cigarettes per day, daily for a period of 28 days. We evaluated the oxidative damage in lipid and protein in the rat brain, and DNA damage in the peripheral blood of male adult offspring rats. To determine oxidative damage in the lipids, we measured the formation of thiobarbituric acid reactive species (TBARS) and the oxidative damage to the proteins was assessed by the determination of carbonyl groups content. We also evaluated DNA damage using single-cell gel electrophoresis (comet assay). Our results showed that rats exposed to CS in the prenatal period presented a significant increase of the lipid peroxidation, protein oxidation and DNA damage in adult age. We can observe that the animals submitted at acute doses of ketamine also presented an increase of the lipid peroxidation and protein oxidation at different doses and structures. Finally, we suggest that exposure to CS during the prenatal period affects two essential cerebral processes during development: redox regulation and DNA integrity, evaluated in adult offspring. These effects can leads to several neurochemical changes similar to the pathophysiology of schizophrenia.

Perfil dos pacientes internados na Divisäo de pediatria do Hospital Universitário da UFSC / Profile of the admitted Pediatric patients in the Hospital Universitario at UFSC

Conhecer o perfil nosológico dos pacientes internados na Divisão de Pediatria do Hospital Universitário da UFSC. Tipo de estudo foi transversal (descritivo). Através do Livro de Registro foram colhidos os dados de 281 pacientes, escolhidos aleatoriamente, internados na Divisão de Pediatria do Hospital Universitário da UFSC entre 01 de janeiro e 31 de dezembro de 1994. Os dados analisados foram os seguintes:sexo, idade, procedência, duraçäo da internaçäo, condiçäo de saída e diagnóstico principal, codificado segundo a 10 revião da Classificaçäo Internacional de Doenças (CID-10)...

Perfil da Clientela do Serviço de Emergência Pediátrica do Hospital Universitário da UFSC, 1994 / Clientele Profile of the Pediatric Emergency Service of University Hospital at UFSC in 1994

A fim de se conhecer o perfil nosológico da clientela do Serviço de Emergência Pediátrica do Hospital Universitário da UFSC, foram estudadas 463 fichas de atendimento de pacientes atendidos neste serviço em 1994. Os diagnósticos foram codificados de acordo com 10 revisão da Classificação Internacional de Doenças. A maioria dos pacientes tinha até cinco anos de idade setenta e cinco e dois porcento e era procedente da região insular de Florianópolis oitenta e um porcento...