[Functional state of the rat liver exposed to the primary damaging action of impact G forces]. / Funktsional'noe sostoianie pecheni krys pri pervichnom povrezhdaiushchem deistvii udarnykh peregruzok.

White rats were exposed to undamaging and producing the primary damage (focal hemorrhages in the lung tissue) effects of impact acceleration. Biochemical parameters of the blood characterizing the functional state of the liver parenchyma were studied. Histological and histochemical changes in this organ were also investigated. It was demonstrated that impact acceleration that induced microlesions of the lung tissue damaged the liver parenchyma as well. However, in contrast to lesions located in the lung tissue, liver damages cannot be discerned visually since they mainly involve metabolic changes. These changes are suggested by blood biochemistries indicating alteration or inhibition of specific functions of the liver: biosynthesis of cholesterol, urea, etc. Thus, a study of partial functions of the liver is a promising procedure to help evaluate possible effects of an exposure and, first of all, differentiate in vivo undamaging and damaging (pathological) effects of impact acceleration.

[Evaluation of the effect of impact stresses on the body according to laboratory study data]. / Otsenka deistviia udarnykh peregruzok na organizm po dannym laboratornykh issledovanii

In three experiments on white rats and in two experiments on volunteers variations of 20 clinical and laboratory parameters were investigated upon an exposure to impact accelerations. The results demonstrated a correlation between changes in the general state of the animals and morphology of viscera, on the one hand, and changes of hematological and biochemical parameters, on the other. A scheme of utilizing more informative parameters for the in vivo differentiation of effects of impact accelerations is recommended. Manned experiments indicate that measurements of urine excretion of endogenous creatinine hold promise for these purposes.