Dilatation of Common Iliac Arteries after Endovascular Infrarenal Abdominal Aortic Repair with Bell-Bottom Extension.

OBJECTIVE: Endovascular techniques to treat abdominal aortic aneurysms results in lower morbidity and mortality rates. However, dilation of the common iliac arteries prevents adequate distal sealing, which compromises the procedure success. The aim of this study is report the long-term outcomes of patients with abdominal aortic aneurysms associated with aneurysm of the common iliac artery following endovascular repair using a bifurcated bell-bottom stent graft. METHODS: This is a retrospective study that evaluated patients treated with bifurcated bell-bottom extension stent grafts to repair an infrarenal abdominal aortic aneurysm and who had at least one common iliac artery with dilatation ≥ 1.5 cm for at least 12 months after the endovascular intervention. RESULTS: Thirty-eight patients with a mean age of 70.4±8.2 years were included. Stent graft placement was followed by dilation of the common iliac artery aneurysms in 35.3% of cases; endoleak and reoperation rates were 17.6% and 15.7%, respectively. Younger patients showed a higher rate of artery diameter increase following the procedure. The average arterial dilation was 16% in the first year, 29% in the second year, 57% in the third year and 95% from the fourth year until the end of follow-up. CONCLUSION: Repair of infrarenal abdominal aortic aneurysms with bifurcated bell-bottom type stents when there is common iliac artery dilation is a good therapeutic option to preserve hypogastric flow. The rate of endoleak was 17.6%, and 15.7% of cases required reoperation. Younger patients are more likely to experience dilation of the common iliac artery after the procedure.

Dilatation of common iliac arteries after endovascular infrarenal abdominal aortic repair with bell-bottom extension

Abstract Objective: Endovascular techniques to treat abdominal aortic aneurysms results in lower morbidity and mortality rates. However, dilation of the common iliac arteries prevents adequate distal sealing, which compromises the procedure success. The aim of this study is report the long-term outcomes of patients with abdominal aortic aneurysms associated with aneurysm of the common iliac artery following endovascular repair using a bifurcated bell-bottom stent graft. Methods: This is a retrospective study that evaluated patients treated with bifurcated bell-bottom extension stent grafts to repair an infrarenal abdominal aortic aneurysm and who had at least one common iliac artery with dilatation > 1.5 cm for at least 12 months after the endovascular intervention. Results: Thirty-eight patients with a mean age of 70.4±8.2 years were included. Stent graft placement was followed by dilation of the common iliac artery aneurysms in 35.3% of cases; endoleak and reoperation rates were 17.6% and 15.7%, respectively. Younger patients showed a higher rate of artery diameter increase following the procedure. The average arterial dilation was 16% in the first year, 29% in the second year, 57% in the third year and 95% from the fourth year until the end of follow-up. Conclusion: Repair of infrarenal abdominal aortic aneurysms with bifurcated bell-bottom type stents when there is common iliac artery dilation is a good therapeutic option to preserve hypogastric flow. The rate of endoleak was 17.6%, and 15.7% of cases required reoperation. Younger patients are more likely to experience dilation of the common iliac artery after the procedure.

[Mediastinal liposarcoma: a case report]. / Lipossarcoma de mediastino: relato de caso.

Here, we describe the case of a 51-year-old female with mediastinal liposarcoma. Liposarcoma is the most common malignant mesenchymal neoplasm in adults, although a mediastinal location is extremely rare. It has a large volume and varied histologic subtypes. It is characterized by the compression of neighboring structures. Computed tomography and magnetic resonance imaging provide useful data for diagnosis. Tissue biopsy and histological typing are very important in determining the treatment and are needed for the final diagnosis. Radiotherapy and chemotherapy are ineffective treatment modalities. According to the literature, surgical resection is the treatment of choice. Long-term follow-up evaluation is indicated since there is a high rate of recurrence.

Lipossarcoma de mediastino: relato de caso / Mediastinal liposarcoma: a case report

Relatamos o caso de uma mulher de 51 anos com lipossarcoma mediastinal. O lipossarcoma é a neoplasia mesenquimal maligna mais comum em adultos, embora sua localização mediastinal seja extremamente rara. Ele possui grande volume e variados subtipos histológicos. É caracterizado pela compressão de estruturas vizinhas. A tomografia computadorizada e a ressonância magnética fornecem informações úteis para o diagnóstico.A biopsia tecidual e a identificação do tipo histológico são importantes na determinação da terapia e são necessárias para o diagnóstico final. A radioterapia e a quimioterapia são modalidades terapêuticas ineficazes. De acordo com a literatura, a ressecção cirúrgica é o tratamento de escolha. Está indicado o acompanhamento a longo prazo, pois a taxa de recidiva é alta.

Here, we describe the case of a 51-year-old female with mediastinal liposarcoma. Liposarcoma is the most common malignant mesenchymal neoplasm in adults, although a mediastinal location is extremely rare. It has a large volume and varied histologic subtypes. It is characterized by the compression of neighboring structures. Computed tomography and magnetic resonance imaging provide useful data for diagnosis. Tissue biopsy and histological typing are very important in determining the treatment and are needed for the final diagnosis. Radiotherapy and chemotherapy are ineffective treatment modalities. According to the literature, surgical resection is the treatment of choice. Long-term follow-up evaluation is indicated since there is a high rate of recurrence.

Effect of aging on liver regeneration in rats

OBJETIVO: Acredita-se que idosos tenham maior dificuldade de regenerar e/ou cicatrizar tecidos. O fígado é um dos mais complexos órgãos do corpo humano, e está envolvido em diversas funções. A regeneração hepática representa um mecanismo de proteção orgânica contra a perda de tecido hepático funcionante. O objetivo do presente estudo é reconhecer a capacidade regenerativa do fígado de animais velhos e compará-la com a de animais adultos jovens.MÉTODOS: Foram utilizados 34 ratos Wistar, 17 com 90 dias (jovens) e 17 com 460 dias (velhos). Aproximadamente 70% do fígado foi cirurgicamente removido. As aferições foram feitas com 24 horas e com 7 dias, com 3 métodos: Fórmula de KWON et al para reconhecer ganho de volume, contagem das figuras de mitose existentes em 5 campos e percentual dos núcleos PCNA positivos em 5 campos. RESULTADOS: O remanescente hepático ganhou maior volume nos animais jovens tanto com 24 horas (p=0,0006) quanto com 7 dias (p=0,0000). Os cortes histológicos revelaram maior número de figuras de mitose nos fígados dos jovens avaliados com 24 horas (p=0,0000). Na avaliação com 7 dias houve recuperação nos velhos, que se aproximaram dos jovens (p=0,2851). A contagem dos núcleos PCNA positivos foi maior nos cortes dos fígados dos jovens, com 24 horas (p=0,0310) e enquanto diminuiu nos jovens com 7 dias, nos velhos houve recuperação (p=0,0298). CONCLUSÃO: Os dados confirmam que a idade está relacionada com o atraso da regeneração hepática, em ratos.

Effect of aging on liver regeneration in rats / Efeitos do envelhecimento na regeneração hepática em ratos

OBJETIVO: Acredita-se que idosos tenham maior dificuldade de regenerar e/ou cicatrizar tecidos. O fígado é um dos mais complexos órgãos do corpo humano, e está envolvido em diversas funções. A regeneração hepática representa um mecanismo de proteção orgânica contra a perda de tecido hepático funcionante. O objetivo do presente estudo é reconhecer a capacidade regenerativa do fígado de animais velhos e compará-la com a de animais adultos jovens.MÉTODOS: Foram utilizados 34 ratos Wistar, 17 com 90 dias (jovens) e 17 com 460 dias (velhos). Aproximadamente 70% do fígado foi cirurgicamente removido. As aferições foram feitas com 24 horas e com 7 dias, com 3 métodos: Fórmula de KWON et al para reconhecer ganho de volume, contagem das figuras de mitose existentes em 5 campos e percentual dos núcleos PCNA positivos em 5 campos. RESULTADOS: O remanescente hepático ganhou maior volume nos animais jovens tanto com 24 horas (p=0,0006) quanto com 7 dias (p=0,0000). Os cortes histológicos revelaram maior número de figuras de mitose nos fígados dos jovens avaliados com 24 horas (p=0,0000). Na avaliação com 7 dias houve recuperação nos velhos, que se aproximaram dos jovens (p=0,2851). A contagem dos núcleos PCNA positivos foi maior nos cortes dos fígados dos jovens, com 24 horas (p=0,0310) e enquanto diminuiu nos jovens com 7 dias, nos velhos houve recuperação (p=0,0298). CONCLUSÃO: Os dados confirmam que a idade está relacionada com o atraso da regeneração hepática, em ratos.(AU)

PURPOSE: Regeneration and/or healing of tissues is believed to be more difficult in elderly people. The liver is one of the most complex organs in the human body, and is involved in a variety of functions. Liver regeneration is the body's protection mechanism against loss of functional liver tissue. The aim of this study is to identify the regenerative capacity of the liver in older animals and to compare it with that of young adult animals. METHODS: Thirty-four Wistar rats were used, of which 17 were 90 days old (young animals) and 17 were 460 days old (old animals). Approximately 70% of the liver was surgically removed. Examinations were carried out after 24 hours and on day 7, using 3 methods: KWON et al.'s formula to identify increase in volume; mitotic figure count in 5 fields; and the percentage of PCNA-positive nuclei in 5 fields. RESULTS: The increase in volume of the remaining liver was greater in the young animals after both 24 hours (p=0.0006) and on day 7 (p=0.0000). Histological cuts showed a greater mitotic figure count in young animals evaluated after 24 hours (p=0.0000). Upon evaluation on day 7, recovery was observed in the old animals. This recovery was similar to that of the young ones (p=0.2851). The PCNA-positive nucleus count was greater in the young animals' liver cuts after 24 hours (p=0.0310), and, while it had decreased in young animals by day 7, recovery was observed in the older animals (p=0.0298). CONCLUSION: The data confirm that age is related to delay in liver regeneration in rats.(AU)

Effect of aging on liver regeneration in rats.

PURPOSE: Regeneration and/or healing of tissues is believed to be more difficult in elderly people. The liver is one of the most complex organs in the human body, and is involved in a variety of functions. Liver regeneration is the body's protection mechanism against loss of functional liver tissue. The aim of this study is to identify the regenerative capacity of the liver in older animals and to compare it with that of young adult animals. METHODS: Thirty-four Wistar rats were used, of which 17 were 90 days old (young animals) and 17 were 460 days old (old animals). Approximately 70% of the liver was surgically removed. Examinations were carried out after 24 hours and on day 7, using 3 methods: KWON et al.'s formula to identify increase in volume; mitotic figure count in 5 fields; and the percentage of PCNA-positive nuclei in 5 fields. RESULTS: The increase in volume of the remaining liver was greater in the young animals after both 24 hours (p=0.0006) and on day 7 (p=0.0000). Histological cuts showed a greater mitotic figure count in young animals evaluated after 24 hours (p=0.0000). Upon evaluation on day 7, recovery was observed in the old animals. This recovery was similar to that of the young ones (p=0.2851). The PCNA-positive nucleus count was greater in the young animals' liver cuts after 24 hours (p=0.0310), and, while it had decreased in young animals by day 7, recovery was observed in the older animals (p=0.0298). CONCLUSION: The data confirm that age is related to delay in liver regeneration in rats.