Internet access and partnership formation in the United States.

The Internet has fundamentally altered how we communicate and access information and who we can interact with. However, the implications of Internet access for partnership formation are theoretically ambiguous. We examine their association using data from the National Longitudinal Survey of Youth (NLSY97) and Current Population Survey (CPS) in the United States. We find that the relationship between Internet access and partnership states (in the NLSY97) or partnership status (in the CPS) is age-dependent. While negative at the youngest adult ages, the association becomes positive as individuals reach their mid- to late 20s, for both same-sex and different-sex partnerships. The results suggest that Internet access is positively associated with union formation when individuals enter the stage in the young adult life course when they feel ready to commit to a long-term partnership. Our study contributes to a growing literature that highlights the implications of digital technologies for demographic processes.Supplementary material for this article is available at: https://doi.org/10.1080/00324728.2021.1999485.

A Sequence-Analysis Approach to the Study of the Transition to Adulthood in Low- and Middle-Income Countries.

This study investigates whether young people in low- and middle-income countries (LMICs) have experienced processes of destandardization of the life course similar to those observed in high-income societies. We provide two contributions to the relevant literature. First, we use data from 263 Demographic and Health Surveys (DHS) across 69 LMICs, offering the richest comparative account to date of women's transition to adulthood (TTA) patterns in the developing world. In so doing, we adopt sequence analysis and shift the focus from individual life-course events-namely first sexual intercourse, first union, and first birth-to a visually appealing approach that allows us to describe interrelations among events. By focusing on the analysis of trajectories rather than the occurrence of single events, the study provides an in-depth focus on the timing of events, time intervals between events, and how experiencing (or not) one event might have consequences for subsequent markers in the TTA in cross-national comparative perspective. Second, we identify clusters of TTA and explore their changes across cohorts by region and household location of residence (rural vs. urban). We document significant differences by macro-regions, yet relative stability across cohorts. We interpret the latter as suggestive of cultural specificities that make the TTA resistant to change and slow to converge across regions, if converging at all. Also, we find that much of the difference across cluster typologies ensues from variation related to when the transition begins (early vs. late), rather than from the duration between events, which tends to be uniformly quick across three out of four clusters.

Understanding the social and cultural bases of Brexit.

We use data from a large scale and nationally representative survey to evaluate two narratives about the social bases of Brexit. The first narrative sees Brexit as a revolt of the economically left-behinds. The second narrative attributes Brexit to the resurgence of an English nationalism. There is some, albeit not always consistent, evidence that people in relative poverty or those living in areas that have seen greater Chinese import penetration are slightly more pro-Leave. People living in economically deprived neighborhoods are not more pro-Brexit. Using the Weberian class-status distinction, it is social status, not social class, which stratifies Brexit support. Individuals for whom being British is important are more pro-Leave. But those who see themselves as British rather than English, and those reporting omnivorous cultural consumption are less supportive of Brexit. Overall, there is empirical support for both narratives. But the weight of the evidence suggests a strong cultural dimension in Brexit support.

Sexual fluidity and BMI, obesity, and physical activity.

Analyzing reported changes in sexual identity over time is necessary for understanding young adult health risks. Utilizing waves 3 and 4 of the National Longitudinal Study of Adolescent to Adult Health, this paper studies the relationships between sexual identity changes and BMI, obesity, and physical activity among young adults in the U.S (N = 11,349). The results show that men who report a change toward a more homosexual identity have a significantly lower BMI and participate in more physical activity, while men who report a change toward a more heterosexual identity participate in less physical activity and have a higher BMI compared to those who did not report a change. For women, a change toward a more homosexual identity is significantly associated with more physical activity and lower odds of being obese compared to no change. The results suggest that specific sexual identity changes may also be linked to improvements in health.

Fertility History and Biomarkers Using Prospective Data: Evidence From the 1958 National Child Development Study.

Research on the later-life health implications of fertility history has predominantly considered associations with mortality or self-reported indicators of health. Most of this previous research has either not been able to account for selection factors related to both early-life and later-life health or has had to rely on retrospectively reported accounts of childhood circumstances. Using the 1958 National Child Development Study, and in particular the biomedical survey conducted in 2002-2003, we investigate associations between fertility histories (number of children and age at first and at last birth) and biomarkers for cardiometabolic risk and respiratory function in midlife among both men and women. Results from models that adjusted for a very wide range of childhood factors, including early-life socioeconomic position, cognitive ability, and mental health, showed weak associations between parity and biomarkers. However, we found an inverse association between age at first birth and biomarkers indicative of worse cardiometabolic health, with poorer outcomes for those with very young ages at entry to parenthood and increasingly better outcomes for those becoming parents at older ages. A very young age at last birth was also associated with less favorable biomarker levels, especially among women. Results highlight the value of prospectively collected data and the availability of biomarkers in studies of life course determinants of health in midlife and later.

Fertility histories and chronic conditions later in life in Europe.

Understanding the association between fertility histories and health later in life is necessary in the context of ageing societies. Past literature has generally found a U-shaped relationship between parity, age at first birth, and several health-related outcomes. However, these findings differed to some extent depending on the country under analysis and on the measures of health considered. As such, using wave 3 (2008-2009) and 5 (2013) of the Survey of Health, Ageing and Retirement in Europe (SHARE), this work aimed to answer the question: "Are fertility histories associated with the presence of chronic conditions later in life in Europe?" The analysis included 11 European countries and compared results using two different measures of chronic conditions: self-reported chronic or long-term illness and chronic diseases diagnosed by a doctor. Results showed that age at first birth is more relevant than parity for health outcomes at older ages. Moreover, in socio-democratic and continental countries, the association between fertility and chronic conditions-in particular between age at first birth and long-term illnesses-is statistically significant among women, but not among men. Finally, the association between fertility history and health was similar when using self-reported measures and chronic diseases diagnosed by a doctor.

Synergy of cytological methods in the pathological staging of breast cancer: Axillary fine-needle aspiration and intraoperative scrape cytology of the sentinel lymph node.

BACKGROUND: Sentinel lymph node biopsy (SLNB) has become the standard in breast cancer staging, but it is costly and time-consuming. Fine-needle aspiration cytology (FNAC) under ultrasonographic guidance identifies patients who need axillary lymph-node dissection (ALND), thus reducing costs. As an alternative to frozen sections (FS), intraoperative scrape cytology (ISC) for SLNB is an inexpensive, rapid, accurate and safe technique. We evaluated the synergy of FNAC and SLNB in determining the axillary burden and the performance of the ISC method. METHODS: Over a nine-year period, 894 breast cancer patients were analyzed. Of these, 439 patients with echographic suspicious nodes underwent preoperative FNAC; negative axillary ultrasounds or FNACs resulted in 606 intraoperative SLNB, performed using the ISC technique. The results were compared with histological diagnosis, and sensitivity, specificity, predictive values and accuracy were calculated. RESULTS: Of the 439 FNACs, 121 were positive and underwent immediate ALND, and 242 negative patients underwent intraoperative SLNB (69% sensitivity, 99% specificity). Positive cases often had multiple nodal involvement (55% pN2-3). Of the 606 SLNB-ISC smears, 510 were true negative; 65 true positives allowed for one-step ALND (71% sensitivity, 99% specificity). CONCLUSION: Preoperative positive axillary FNAC predicts a higher disease burden and determines the avoidance of SLNB for patients eligible for immediate ALND. ISC instead of FS is a safe and sensitive technique to identify metastases, indicating completion of ALND. PARTIALLY PRESENTED AT: Joint International Oncology (sentinel node & cancer metastasis) Congress, May 27-29, 2013, San Francisco, California, USA 18 ° International Congress of Cytology (ICC 2013-1161), May 26-30, 2013, Paris, France Convegno Nazionale GISMa - Finalborgo (Savona), Italy,19-20 maggio 2016.

Economic Conditions of Young Adults Before and After the Great Recession.

Transition to adulthood has undoubtedly changed in the last few decades. For youth today, an important marker of adulthood is self-actualization in their professional career, and, consequently, also the achievement of stable financial conditions. Economic conditions of youth are greatly subject to fluctuations in the economy, and the subsequent governmental response. Using the Luxembourg Income Study, this work investigates the trends in income from work of young adults before and after the Great Recession of 2008 in five countries-US, UK, Norway, Germany, and Spain. The findings showed deterioration in economic conditions of young men, but with differences across countries. Young women suffered less from the crisis, and in some countries, their economic situation improved. The general negative trend was especially pronounced for those with high education, which is primarily because they stayed in education longer.

Dimensions of sexual orientation and sleep disturbance among young adults.

We examined associations among 3 dimensions of sexual orientation (identity, attraction, and behavior) and sleep disturbance among young adults in the United States. Using Wave IV of the National Longitudinal Study of Adolescent Health (respondents aged 24-32, N = 14,334), we ran multivariate logistic regressions to estimate the probability of reporting trouble falling asleep, trouble staying asleep, and short sleep duration, based on specific sexual orientation categories. Results after controlling for mental health indicate that these categories are more likely to have trouble falling asleep: women who identify as "bisexual" (OR = 1.85, CI: 1.21,2.82), women attracted to "both sexes" (OR = 1.31, CI: 1.00,1.72), women who have had "mostly opposite sex" partners (OR = 1.40, CI: 1.10,1.77), and men who have had "mostly same sex" partners (OR = 2.28, CI: 1.21,4.31). For trouble staying asleep: women who identify as "bisexual" (OR = 1.48, CI: 1.01,2.18), men and women attracted to "both sexes" (OR = 1.81, CI: 1.12,2.91; OR = 1.27, CI: 1.00,1.60), and women who have had "mostly opposite sex partners" (OR = 1.38, CI: 1.13,1.69). For short sleep duration: women who identify as "mostly straight" or "mostly gay" (OR = 1.27, CI: 1.01,1.60; OR = 2.64, CI: 1.36,5.14), men who identify as "bisexual" (OR = 2.56, CI: 1.26,5.18), women attracted only to "same sex" (OR = 2.42, CI: 1.48,3.96), men attracted to "both sexes" (OR = 1.88, CI: 1.21,2.93), and women who have had "mostly same sex" partners (OR = 4.90, CI: 2.10,11.46). Given the variation in findings, it is necessary to analyze each sexual orientation dimension and the categories within each dimension to adequately understand sleep disturbances among sexual minority populations.

Solid Variant of Adenoid Cystic Carcinoma of the Breast: A Case Series With Proposal of a New Grading System.

Adenoid cystic carcinoma (ACC) of the breast is a low-grade malignancy "triple negative" breast tumor. ACC of the breast can present a great variety of morphological features having a prognostic impact. Recently, cases of ACC having solid-basaloid features (SBACC) have been described. In the present study, 6 cases of SBACC have been reported. All the cases affected female patients aged 47 to 69 years (mean = 54 years). Two patients had metastases to the axillary lymph nodes, and 2 patients experienced local recurrences. No deaths due to the tumor were observed. A review of the literature on breast SBACC showed that local recurrences and lymph node metastases are more frequent than in the ACC conventional type; nevertheless, no deaths due to the tumor are registered at the moment. On the contrary, cases of ACC with features of malignant transformation are on record. Therefore, a new grading system on breast ACC is proposed.

Multifocal diffusion of a KPC-3 producing ST512 K. pneumoniae clone in Northern Italy.

Sequence Type 258 (ST258) together with its allelic single- and double-locus variants have mostly been associated with the dissemination of KPC-producing Klebsiella pneumoniae in Europe. A total of 56 nonreplicate K. pneumoniae isolates with decreased carbapenem-susceptibility, collected at 7 different hospitals located in Northern Italy were investigated for the occurrence of blaKPC-type genes. PCR and sequencing results highlighted the presence of blaKPC2 or blaKPC-3 determinants in 10/56 and 5/56 cases respectively. Here we describe the intra- and inter-hospital spread in Northern Italy of a K. pneumoniae ST512 clone harboring the blaKPC-3 gene.

GMP-compliant culture of human hair follicle cells for encapsulation and transplantation.

Human hair follicle cells, both bulge and dermal papilla cells, were isolated and cultured in a GMP cell factory, in order to obtain an in vitro hair follicle source for encapsulation end transplantation in alopecia regenerative cell therapy. An in vitro model, constituted by organotypic cultures of human skin sample, was set up to simulate the dermal-epidermal interaction between bulge cells and dermal papilla cells, evaluating the possible new follicles formation and the regenerative potentiality of these hair follicle cells. Both the bulge and dermal papilla cells show an excellent cellular proliferation as well as an abundant extracellular matrix production. The immunofluorescence investigation revealed the positivity of both cell lines to CK15 and CD200, whereas both cell lines were negative to CD71 and Oct-4. The pool of cultured bulge and dermal papilla cells was injected into the deep dermis; at day 28 of culture, some organized areas with a higher cell density can be observed: the cells self-organize into papilla-like lengthened aggregates. In samples in which the follicular cells have been seeded on the dermis surface, an epidermis-like homogeneous monolayer on the dermis surface can be seen, therefore showing a potentiality of these cells for epidermis regeneration. These data show the efficacy of a cellular isolation and amplification approach to obtain an in vitro human hair follicle regenerative source on industrial scale in a GMP cell factory. The results also proved an intrinsic potentiality of follicular cells to in vitro recreate the epidermis for tissue engineering purposes. Thus, it is feasible to produce bioengineered hair follicles in a GMP cell factory, for encapsulation and transplantation in alopecic patients.

Rare abdominal metastases from occult lobular breast cancer: report of two cases.

Intra-abdominal metastases from breast carcinomas are rarely reported in the literature. Least are those originating from occult breast primary. We report, one case of pancreatic metastasis and one case of metastatic infiltration of the colonic wall, both by occult lobular breast carcinoma. The first patient underwent pancreaticoduodenectomy for obstructive jaundice, with unexpected histological finding of infiltration of distal bile duct, pancreatic gland, portal vein and retroperitoneal soft tissue by lobular carcinoma of the breast. The second patient complained of diffuse abdominal pain associated with constipation and rectal bleeding and underwent endoscopic biopsy of three intestinal strictures, revealing metastatic lobular carcinoma with signet-ring cell morphology. In both cases, a subsequent complete diagnostic work-up demonstrated asymptomatic multiple breast nodules, diagnosed as lobular carcinoma by fine needle aspiration cytology.

Oncocytic angiomyolipoma of the kidney: a case report.

We describe a case of oncocytic angiomyolipoma composed of polygonal eosinophilic cells, that shares many features with renal oncocytoma. It was composed of alveolar structures, with accumulation of foamy histiocyte-like cells surrounding large globules of acellular, nonfibrillary, densely eosinophilic basal membrane-like substance. Immunohistochemically, there was focal reactivity for HMB45 and negativity for the epithelial markers. Oncocytic angiomyolipoma lacks the atypical features of the recently described epithelioid variant of angiomyolipoma. None of the reported cases have been associated with tuberous sclerosis.