RESUMO
PURPOSE: To study the effect of the modulation of inositol hexaphosphate (IP6) in the biological immunohistochemistry expression of cellular signaling marker apoptosis, in model of carcinogenesis of colon induced by azoxymethane (AOM). METHODS: Wistar rats (N=112) distributed in 4 groups (n=28): Control; B, AOM (5 mg kg-1, 2x, to break week 3); C, IP6 (in water 1%, six weeks); D, IP6+AOM. Weekly euthanasia (n=7), from week three. Immunohistochemistry of ascendant colon with biological marker inositol 1,4,5 triphosphate receptor type III (Itpr3). Quantification of the immune-expression with use of computer-assisted image processing. Analysis statistics of the means between groups, weeks in groups, groups in weeks, and established significance when pAssuntos
Apoptose/efeitos dos fármacos
, Biomarcadores Tumorais/metabolismo
, Neoplasias do Colo/metabolismo
, Receptores de Inositol 1,4,5-Trifosfato/metabolismo
, Ácido Fítico/farmacologia
, Animais
, Azoximetano
, Carcinógenos
, Neoplasias do Colo/induzido quimicamente
, Imuno-Histoquímica
, Masculino
, Ratos
, Ratos Wistar