[Tuberculosis thanatogenesis and pathoanatomy of caseous pneumonia]. / Tanatogenez tuberkuleza i patologicheskaia anatomiia kazeoznoi pnevmonii.

Tuberculosis thanatogenesis of today has been studied on autopsy and operative material. Pathoanatomy and mechanism of development of caseous pneumonia have been investigated: types of tissue reactions and role of terminal and respiratory bronchioles in the development of caseous pneumonia are shown and early phases of pathological changes of the connective tissue and interstitium (acute mesenchymopathy) distinguished. Caseous pneumonia has been distinguished for the first time. Its reversible phase may be cured by modern treatment strategy, whereas in its irreversible form not only conservative, but urgent surgical treatment is indicated.

[Changes in the fibronectin level of the blood and bronchoalveolar lavage fluid in experimental tuberculosis in guinea pigs]. / Izmenenie urovnia fibronektina v krovi i zhidkosti bronkhoal'veoliarnogo lavazha pri éksperimental'nom tuberkuleze u morskikh svinok.

The study was made of 64 guinea pigs with induced generalized tuberculosis which underwent no treatment, 60 infected animals receiving chemotherapy 2 weeks after the inoculation and 16 healthy animals. Citrate plasma and bronchoalveolar lavage (BAL) fluid of all the animals was examined for fibronectin (FN) concentrations using ELISA. The measurements were made 1 week, 1 and 2 months following inoculation and 2 weeks, 1.5 and 2.5 months after the start of the treatment. Histological investigations of the lungs, liver and spleen were performed at the same terms. It was established that for generalized tuberculosis developing spontaneously FN changes are characterized by multidirectional trends, seen more markedly at the terminal stage of the process. A long-term specific therapy was associated with rising FN levels in the blood and BAL fluid.

[Ways of increasing the effectiveness of surgical treatment of patients with chronic empyema]. / Puti povysheniia éffektivnosti khirurgicheskogo lecheniia bol'nykh s khronicheskoi émpiemoi plevry.

A dynamic morphologic examination and surgical treatment analysis in connection with 184 patients with chronic empyema of the chest appeared to be the basis to refer to it as an independent form of pleuropulmonary pathology with a typical undulatory clinical course and morphologic picture. The disease is evolving progressively, with predominant hyperplastic processes in the changed pleura leaves at the initial, and as a rule lengthy stage in relation to a stable course, accompanied by subsequent aggravation and easing of the process in addition to the development of complications. Depending on the clinical course stage, a surgical treatment tactics is elaborated together with the use of different surgical methods. The application of surgical intervention of a restorative nature at early stages of the disease is stipulated, since it gains good results and prevents the development of serious, hardly curable forms.

[Structure of thromboembolic complications (based on prosection data of the Department of Pathological Anatomy of the I. M. Sechenov I Moscow Medical Institute from 1962 to 1979)]. / Struktura tromboémbolicheskikh oslozhnenii (po materialam prozektury kafedry patologicheskoi anatomii I Moskovskogo meditsinskogo instituta im. I. M. Sechenova s 1962 po 1979 g.).

Based on the study of the materials of 13,000 autopsies made in 1962--1979 at the Pathology Department of the Chair of Pathological Anatomy of the I. M. Sechenov First Medical Institute, an increase in the rate of thromboembolic complications (TEC) was established predominantly in diseases of the cardiovascular system (atherosclerosis, hypertension, ischemic heart disease, rheumatic disease, protracted bacterial endocarditis). The analysis of 8157 autopsies with TEC revealed general regularities of changes in TEC structure in different diseases irrespective of their pathogenetic differences: predominance in the last two decades of venous thrombs, thromboemboly of the pulmonary artery and pulmonary infarction; prevalence of senescent and senile people among patients with TEC, and women among them (with the exception of protracted bacterial endocarditis).

[New method of differential histological diagnosis of different forms of amyloidosis]. / Novyi sposob differentsial'noi gistologicheskoi diagnostiki form amiloidoza.

A new method for morphological diagnosis of various forms of amyloidosis based on the use of a hot buffered hexamine-silver solution is suggested. Its potentials are illustrated on 37 cases of primary, hereditary, and secondary human amyloidosis as well as experimental amyloidosis. The proposed method permits morphological differential diagnosis of amyloidosis in those cases where other methods failed to do it.

[Clinico-morphologic characteristics of periodic disease]. / Kliniko-morfologicheskaia kharakteristika periodicheskoi bolezni

The article deals with clinico-anatomical characteristics of two observations over periodical disease. Peculiar features of the developing in this case of genetic amyloidosis, which is considered as a disease of accumulation, are analysed.