[Short-term pharmacological block of the atrioventricular node in the diagnosis of cardiac arrhythmias]. / Kratkovremennaia farmakologicheskaia blokada predserdno-zheludochkovogo uzla v diagnostike aritmii serdtsa.

73 patients were examined with the aim of establishing the clinical importance of the method of short-term pharmacologic blockage (SPB) of atrioventricular node (AVN) in the diagnosis of paroxysmal tachycardias, latent forms of ventricular pre-excitation and attached forms of parasystole. SPB AVN was performed as an intravenous bolus of adenosinetriphosphate (ATP) in graded doses (10-30 mg) with simultaneous ECG recording. If adverse effects of ATP occurred its reinfusions were tapered to a dose of 5-10-15 mg in the presence of preliminary intravenously administered verapamil (5 mg). Objective nature of the diagnostic information obtained by using SPB AVN in the above outlined cardiac arrhythmias is analysed.

[The clinical efficacy of verapamil in ventricular extrasystolic arrhythmia and parasystole]. / Klinicheskaia éffektivnost' verapamila pri zheludochkovoi ékstrasistolicheskoi aritmii i parasistolii.

An arrhythmogenic mechanism has been investigated pharmacologically by acute drug tests (ADT) and alternate block of slow calcium channels and fast sodium channels of the cellular membranes. ADT with verapamil reduced extrasystoles by 60% in 44% of patients demonstrating the predominance of calcium-dependent arrhythmogenesis. An antiarrhythmic efficacy of fast sodium channels blockers was ascertained in 33% of the patients. ADT with rhythmilen and verapamil produced a satisfactory antiarrhythmic effect in 18% of the examinees. These patients seem to have parallel activation of both fast sodium and slow calcium channels. They received courses of both drugs. It is stated that a pharmacological analysis of extrasystolic arrhythmia allows inference on pathogenesis of myocytic electrolyte disturbances which serves the basis for adequate corrective therapy.

[A method for the individual choice of anti-arrhythmia preparations in extrasystole]. / O metodike individual'nogo podbora antiaritmicheskikh preparatov pri ékstrasistole.

Pharmacological analysis of arrhythmogenesis was approved in 60 patients with ventricular extrasystolic arrhythmia (EA). Individual choice of anti-arrhythmia agents (AAA) was realized by successive drug-induced block of slow calcium cancels by isoptin and rapid sodium channel by class I AAA. Changes of arrhythmogenesis were registered electrocardiographically. Acute tests with isoptin revealed a good antiarrhythmic effect in 46.67%, with AAA--in 30%. It is concluded that methods of pharmacological analysis of arrhythmogenesis widely used in experimental cardiology may be used in the clinic for individual choice of AAA.