[LD isoenzyme in uterine aspirates a potential marker of endometrial cancer. Investigation of postmenopausal bleeding can be simpler and cheaper]. / LD-isoenzym i uterusaspirat potentiell markör för endometriecancer. Utredning av postmenopausal blödning kan bli enklare och billigare.

In diagnosing endometrial carcinoma in women with postmenopausal bleeding analysis of lactate dehydrogenase, LD, isoenzymes in uterine aspirates appeared to have 100 percent sensitivity and negative predictive value combined with high specificity and positive predictive value. Determination of the LD-profile is suggested as a marker for endometrial carcinoma in women with postmenopausal bleeding. Transvaginal ultrasonography might be combined with determination of the LD-isoenzyme profile to secure the diagnosis of endometrial malignancy in order to minimize the use of other more invasive diagnostic methods.

Pancreatic Isoamylase as a Routine Test.

α-Amylase (1,4 -α-D-glucan-4-glucanohydrolase E. C. 3.2.1.1.) catalyses the hydrolysis of starch, glycogen and related poly- and oligosaccharides. The end products formed are maltose, short chain dextrins and some glucose. In man large amounts of amylases are secreted into the digestive tract by the salivary and pancreatic glands, minimal amounts also being produced in other tissues. Recently, techniques for specific determination of pancreatic isoamylase activity in plasma have been developed. Routine use of such techniques will increase the clinical value of amylase determination.