[Changes in the vascular wall and ischemic damages to the myocardium in reversible episodes of heart muscle ischemia]. / Izmeneniia sosudistoi stenki i ishemicheskie povrezhdeniia miokarda pri obratimykh épizodakh ishemii serdechnoi myshtsy.

When no anaesthetic is used, even 3-5 short-term disturbances of the myocardium supply with blood (during a few days) are enough for its initial necrosis and for damage of its vascular bed. In acute experiments on rats rutin discovers the ability to resist such damages, but on the chronic model of stenocardia in dogs its therapeutic effect can be found only under conditions of limitation of the ischemic effect by purposefully chosen complex medicinal therapy.

[Effect of small doses of pituitrin on electrocardiography of ischemia in the experiment]. / Vliianie malykh doz pituitrina na ishemicheskie sdvigi élektrokardiogrammy v éksperimente.

A new type of reaction to the myocardial ischemia was established in chronic experiments in conscious dogs. It consists in some changes of local myocardial activity and, consequently, in constant or transient normalization of ECG. Pharmacological stabilization of this process augments myocardial resistance to ischemia 40-50 times and more. The role of small doses of pituitrin in this reaction was established.

[The sequelae of transient myocardial ischemia in chronic experiments]. / Izuchenie posledstvii vremennoi ishemii miokarda v khronicheskikh opytakh.

Reversible short-term and local myocardial ischemia in non-anaesthetized dogs involved a functional (if changing the activity of CPK) and morphologic aftereffect. At the same time it is possible to find some mechanisms of compensation (in chronic experiment).

[Myocardial necrosis in chronic course of ischemic heart disease]. / Nekrozy v miokarde pri khronicheskom techenii ishemicheskoi bolezni serdtsa.

The possibility of myocardial necrosis occurrence in coronary failure proceeding as atypical myocardial infarction was examined in 176 patients with chronic types of coronary heart disease and in experiments with 16 dogs with reversible coronary failure simulated in chronic tests. 99mTe-labeled pyrophosphate myocardial scintigraphy was used in the clinical studies. Myocardial pyrophosphate accumulation was recorded in 37% of patients with angina pectoris without a history of myocardial infarction and 73% myocardial infarction survivals. Histological evidence for small myocardial necroses at various stages of their development was found in 12 dogs. Recurrent transient myocardial ischemias were shown to be able to lead to myocardial necroses that are not always followed by a typical course of acute myocardial infarction.

[Dynamics of changes in the functional activity of blood polymorphonuclear leukocytes in reversible myocardial ischemia in dogs]. / Dinamika izmeneniia funktsional'noi aktivnosti polimorfnoiadernykh leikotsitov krovi pri obratimoi ishemii miokarda u sobak.

Changes in peripheral blood polymorphonuclear leukocytes (PNL) functional activity in dogs during pre- and post-ischemic periods was investigated using the model of dogs venous circulation reversible disturbances in the chronic experiment and luminol-dependent chemiluminescence method. It was demonstrated that single transitory myocardial ischemia (MI) (5 min.) causes positive increase in PNLs functional activity by the 12th-14th hour of post-ischemic period. Repeated short-term MI (5 min.) was accompanied by the increase in phagocytes activity occurring 6-8 hours following the beginning of post-ischemic period, i.e. two times faster than in the case of primary ischemia. The results obtained allow the conclusion that the accumulative effect of multiple MI and the increase in PNLs functional activity as one of the reasons of cardiomyocytes injury in ischemic region cause pronounced inflammatory and necrotic myocardial changes.

[Bioelectrical activity of the vagus nerve in chronic experiments with reversible disorders of the coronary circulation]. / Bioélektricheskaia aktivnost' bluzhdaiushchego nerva v khronicheskikh opytakh s obratimymi narusheniiami koronarnogo krovoobrashcheniia.

Shifts of the ECG and vagal ENG in chronic experiments on dogs with reversible disturbances of coronary circulation involved an increase of the ENG oscillations from 240 +/- 23/sec during cessation of the circulation in a branch of the left coronary artery to 310 +/- 29.4/sec after restoration of the blood flow, both the high- and low-amplitude oscillations being interrelated in a similar way in both cases as 1:9. The data obtained show the ENG shifts to develop ahead of the ECG ischemic changes in coronary blood flow disturbances, the enhancement of vagal electrical response being more obvious in the postischemic period.

[Prevention of ventricular fibrillation in animal experiments]. / Medikamentoznaia profilaktika fibrilliatsii zheludochkov serdtsa v eksperimente.

The precursors of ventricular fibrillation and asystole developing after ligation of a branch of the coronary artery and adrenalin injection were studied in 30 albino rats. The comparative efficacy of antiarrhythmic agents (ajmalin, lidocaine, isoptin, visken) in the prevention of ventricular fibrillation induced by electric current was determined in 40 rats. Ventricular extrasystole and tachysystole as well as the block of the bundle of His branch were the most common precursors of ventricular fibrillation. In some experiments fibrillation was preceded by complete atrioventricular block, cardiac fibrillation, sinus bradycardia, nonparoxysmal ventricular tachycardia, and excaped ventricular contractions. Ventricular asystole was most frequently preceded by complete atrioventricular block and the bundle of His branch block. Among the antiarrhythmic agents studied, ajmalin proved most effective in prevention of ventricular fibrillation; it raised the fibrillation threshold in all animals. Lidocaine, which produced a prophylactic effect in 50% of experiments, was second in effectiveness. Changes in the ventricular fibrillation threshold due to the effect of these agents were statistically significant on the average. Isoptin and visken proved to be less effective.