Aseptic osteonecrosis of the maxilla after severe COVID-19 infection and its treatment.

The course of the new SARS-CoV-2 (COVID-19) is unpredictable and is still being investigated. Although the majority of complications are expected to affect the respiratory system, there have been reports in literature concerning the adverse effects of the infection on bone and joint tissue. Several complications have been observed in the maxillofacial area in people who suffered from the infection, including osteonecrosis and osteomyelitis of the jaw. These complications have been subject to various hypotheses. They may result either from the disease pathogenetic mechanism or from a response to the therapeutic modalities used to treat the underlying disease, and overuse of particular medications - glucocorticoids, antirheumatics, interleukin-6 inhibitors, and antibiotics. This article presents a case of osteonecrosis of the maxilla after severe COVID-19 infection.

[Low Apgar score in term newborn infants and delivery pattern].

OBJECTIVE: Examine the influence of delivery pattern over neonatal condition in the first minutes of life. MATERIALS AND METHODS: We have studied 3624 term newborns of single pregnancies for period of 2 years in the city of Pleven. The patients were divided in 4 groups by the delivery pattern: vaginal delivery with head presentation (2497 infants), vaginal delivery with instrumental assist (45 infants), per vias naturales in breech presentation (44 infants), delivery via Caesarean section (1038 infants). RESULTS: According to our results the Apgar score differs itself from the pathology of a given newborn. Neonatal deaths are significantly higher in the newborns with low Apgar score than deaths in the general population. From all cases of low Apgar score without other clinical problems the highest is the percentage in the infants delivered via Caesarean section. CONCLUSIONS: The goal of the Apgar score is to focus attention on the infant's condition in the first few minutes of its life and the need of resuscitation. Low Apgar score is an important predictor of the newborn morbidity and death rate. The Apgar score alone is not a proof for intrapartal asphyxia and is not associated with long-term neurological damage.

[Adrenal hemorrhage in a newborn with factor V Leiden--a clinical case].

Neonatal adrenal hemorrhage is frequently associated with birth trauma, perinatal asphyxia, septicemia, coagulation defects and thromboembolism. We report a case of bilateral adrenal hemorrhage in newborn baby with perinatal asphyxia. Ultrasound findings of subacute adrenal hemorrhage draw attention to its presumable antenatal genesis. DNA analysis for thrombophilic mutations identifies factor V Leiden.

[Our experience with linesolid usage in newborn children].

The Gram-positive infections are a problem with increasing significance in the newborn period. LINEZOLID is the first member of the new group antibiotics--oxazolidinones. The most Gram-positive infections, including the resistant of vancomycin, influence by LINEZOLID. We treated twenty newborn babies with LINEZOLID during the period from April 2005 to April 2006. Initial empiric antibiotic therapy appointed all those children. Various Gram-positive cocci were isolated from different biological materials. Five assays were sterile, but the clinical signs were suspect for Gram-positive infection. The treatment with LINEZOLID initialized immediately after the identification of the microbiological agent or when was suspect the resistant of initial antibiotics gram-positive infection. Duration of therapy was determined by the elimination of the microbiological agent or by the involution of the clinical signs, which we observed in the all cases of the treatment with LINEZOLID. Our results received up to date demonstrate the effectiveness and the safety of the LINEZOLID treatment in the newborn period.