RESUMO
The purpose of this literature review is to optimize the use of cephalometric diagnostic methods for assessing the condition of the upper respiratory tract. The article examines the areas of the upper respiratory tract associated with obstructive sleep apnea syndrome (OSA). Cephalometric analysis can be a useful tool for screening this pathology. However, it should be noted that there is still no clear understanding of the results of cephalometric changes in OSA, and therefore further research is necessary.
Assuntos
Apneia Obstrutiva do Sono , Tomografia Computadorizada de Feixe Cônico Espiral , Humanos , Polissonografia , Cefalometria , Apneia Obstrutiva do Sono/diagnóstico por imagem , Apneia Obstrutiva do Sono/patologia , RadiografiaRESUMO
BACKGROUND: Ipilimumab is a cytotoxic T-lymphocyte antigen-4 antibody that enhances T-cell activity and proliferation. METHODS: In a retrospective analysis of 86 patients the clinical benefits of ipilimumab treatment were correlated with laboratory and clinical data. RESULTS: A lactate dehydrogenase (LDH) value within the normal range before the start of therapy was significantly correlated with better OS (p ≤ 0.009). An increase in LDH level after two cycles was indicative of a poor outcome, and was significantly negatively correlated with treatment response and overall survival and progression-free survival. 42% of all patients suffered from autoimmune toxicity (CTCAE grades 2-4). The occurrence of autoimmune toxicity clearly correlated with clinical benefit. CONCLUSION: Changes in LDH level and side effects correlate with response to therapy and survival.