Prenylated Flavonoids and Phenolic Compounds from the Rhizomes of Marine Phanerogam Cymodocea nodosa.

Chemical investigation of the rhizomes of the marine phanerogam Cymodocea nodosa resulted in the isolation of two new prenylated flavon-di-O-glycosides, cymodioside A (1: ) and B (2: ), along with known phenolic compounds 3: -7: , some of which never reported from seagrasses to date. The structures of compounds 1: and 2: were established by extensive nuclear magnetic resonance analysis. In addition, the absolute configuration of 4-(2,5-dihydroxyhexyl) benzene-1,2-diol (7: ), which was not previously reported in the literature, has been now determined.