1.
Biull Eksp Biol Med
; 108(10): 459-61, 1989 Oct.
Artigo
em Russo
| MEDLINE
| ID: mdl-2597761
RESUMO
Using radioligand assay it was demonstrated that chlorophos intoxication produced inhibiting effect on the kinetics of membrane binding of 3H3-quinuclidinylbenzilate and 14C-cyclosil in the brain. Cholinesterase reactivator dipyroxime was shown to induce normalization of the cyclosyl specific binding kinetics. It seems to be justified to propose that cooperative action of cholinolytic agents and cholinesterase reactivator at the level of m-cholinoreceptors in the course of intoxication may be one of the mechanisms of the potentiation of therapeutic effects of these drugs.
Assuntos
Encéfalo/metabolismo , Muscarina/antagonistas & inibidores , Triclorfon/intoxicação , Animais , Radioisótopos de Carbono , Reativadores da Colinesterase/farmacologia , Cinética , Masculino , Parassimpatolíticos/metabolismo , Fenetilaminas/metabolismo , Quinuclidinil Benzilato/metabolismo , Ensaio Radioligante , Ratos , Receptores Colinérgicos/efeitos dos fármacos , Receptores Colinérgicos/metabolismo , Trimedoxima/farmacologia , Trítio
2.
Vrach Delo
; 5: 47, 1972 May.
Artigo
em Russo
| MEDLINE
| ID: mdl-5029798