Climate Change Impacts on Urban Sanitation: A Systematic Review and Failure Mode Analysis.

Climate change will stress urban sanitation systems. Although urban sanitation uses various infrastructure types and service systems, current research appears skewed toward a small subset of cases. We conducted a systematic literature review to critically appraise the evidence for climate change impacts on all urban sanitation system types. We included road-based transport networks, an essential part of fecal sludge management systems. We combined the evidence on climate change impacts with the existing knowledge about modes of urban sanitation failures. We found a predominance of studies that assess climate impacts on centralized sewerage in high-income contexts. The implications of climate change for urban nonsewered and complex, fragmented, and (partially) decentralized sanitation systems remain under-researched. In addition, the understanding of the impacts of climate change on urban sanitation systems fails to take a comprehensive citywide perspective considering interdependencies with other sectors and combinations of climate effects. We conclude that the evidence for climate change impacts on urban sanitation systems is weak. To date, research neither adequately represents the variety of urban sanitation infrastructure and service systems nor reflects the operational and management challenges of already stressed systems.

Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody.

Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody.

Denormalizing a historical problem: teen pregnancy, policy, and public health action.

OBJECTIVE: To explore the impact of teen-adult sexual relationships as a public health threat and the effectiveness of statutory rape laws in protecting adolescent children. METHODS: A comprehensive review of current literature surrounding child abuse, teen pregnancy, and statutory rape was conducted. RESULTS: Of one million teen girls who become pregnant each year, two-thirds may be the victims of statutory rape. Current laws appear to marginalize the severity of teen- adult sexual relationships, compromising the health and safety of adolescent children. CONCLUSIONS: Public health recommendations which include public policy change and enforcement, education, and community empowerment are offered.