Semi-Structured Interviews to Evaluate a BCMA Implementation Trouble Areas.

Errors in medication administration involve risks to patient safety. "Bar-Coding Medication Administration" is implemented to prevent these errors. Adoption by nurses is one of the main determinants of their effectiveness. The Hospital Italiano de Buenos Aires implemented BCMA 6 years ago, but its adoption rate still finds resistance in certain sectors. We conducted semi-structured interviews with nursing staff to explore the barriers to the use in low-usage wards and explore the current perceptions of nurses. While nurses recognised the safety and usefulness of the BCMA system, they reported many difficulties. The feedback obtained through this process was useful for the implementation team to plan future interventions, priorities and improvements on the system. The semi-structured interview methodology proved useful as a continuous monitoring strategy.

Experience Story: How Do We Re-Implement What Has Been Implemented?

Since 2017, the Hospital Italiano de Buenos Aires, has a "Workstation on Wheels" project were nurses can access to a mobile application in order to register the drug's administration, vital signs and complete an early warning assessment scale of the hemodynamic state of the patient. Although the overall objective was to achieve at least 95% drug registration through this system, their use did not remain stable over time. Therefore, it was necessary to create an interdisciplinary team to make a diagnosis of the project situation and reasons for the low use rate. In this process, a re-implementation of the barcoding administration system was carried out, focusing on the nursing staff maintaining the use of the system over time. The aim of this paper is to describe the experience and lessons learned in the process of re-implementing the drug barcoding system at the patient's bedside.

Simple production of hydrophobin-fused domain III of dengue envelope protein and induction of neutralizing antibodies against the homotypic serotype of dengue virus.

Hydrophobin-fused domain III of dengue envelope proteins serotypes 1 and 2 were expressed in Rachiplusia nu larvae and purified by aqueous two-phase system. This biotechnological approach of hydrophobin-fused proteins, which allowed obtaining 97.7 µg/larva of fusion protein DomIII serotype 1 and 61.4 µg/larva of fusion protein DomIII serotype 2, represents an integrated strategy for simple production of recombinant antigens. Purified fusion proteins induced serotype-specific neutralizing antibodies without cross-reaction against other serotypes and arboviruses after mouse immunization. hydrophobin-fused domain III of dengue envelope protein could be a promising strategy for easy and low-cost production of components of a tetravalent sub-unit vaccine against dengue.

Hospitales sostenibles frente al cambio climático: Huella de carbono de un hospital público de la ciudad de Buenos Aires / Sustainable Hospitals Facing Climate Change: Carbon Footprint of a Public Hospital in Buenos Aires City

El cambio climático es una cuestión de salud pública. La huella de carbono constituye parte esencial de la huella ecológica de una entidad, que mide la superficie biológica necesaria para producir los bienes y servicios consumidos por la misma, así como la capacidad para asimilar los residuos que genera, por lo que es importante su estimación como indicadora del impacto ambiental que generan las actividades del establecimiento. OBJETIVOS: Estimar la huella de carbono del Hospital General de Agudos Enrique Tornú de la Ciudad Autónoma de Buenos Aires en 2015. MÉTODOS: estudio cuali-cuantitativo descriptivo, de tipo transversal, que incluyó las fuentes emisoras de gases con efecto invernadero para calcular las emisiones de las actividades del hospital desde la perspectiva de una organización. RESULTADOS: La huella de carbono obtenida en toneladas de dióxido de carbono equivalente fue 1526,47. El 43% fueron generadas por emisiones directas, 29% por emisiones indirectas por consumo de energía y el 28% restante por otras emisiones indirectas. Indicador obtenido: I2015 = 9,09 tCO2e/cama. CONCLUSIONES: Los resultados muestran el impacto ambiental generado por el funcionamiento del hospital y su contribución al calentamiento global. Los aportes de cada actividad permiten identificar las fuentes de emisión de mayor peso como áreas de oportunidad para la implementación de estrategias de reducción y/o mitigación. El indicador de desempeño permitirá medir avances en términos de reducción programada de emisiones

Perceptions of Primary Health Care Professionals towards Alcoholic Patients: an Exploratory Study in a Brazilian Municipality / Percepciones de profesionales de atención primaria en salud sobre pacientes alcohólicos: un estudio exploratorio en una municipalidad brasileña

The objectives of the present research were to explore perceptions of Primary Health Care professionals towards alcoholic patients and to verify possible differences in the perceptions of male and female alcoholism. Participants read and responded to three case vignettes describing a male alcoholic, a female alcoholic and a male diabetic. Data were analyzed with repeated measures MANOVA and univariate F follow-up tests. Results showed that the alcoholic was objectified as an "atypical and difficult" patient towards whom there were negative attitudes and stigma-related socio-cognitive elements. Female alcoholism was possibly perceived as more difficult to explain than male alcoholism. The discussion highlights the importance of social representations and social identities in the continued training of health personnel.

Los objetivos de la presente investigación fueron la exploración de las percepciones de profesionales de atención primaria en salud sobre los pacientes alcohólicos y la verificación de posibles diferencias en las percepciones del alcoholismo masculino y femenino. Los participantes respondieron a tres viñetas que describían un paciente alcohólico, una paciente alcohólica y un paciente diabético. Los datos fueron analizados con MANOVA de medidas repetidas y con test univariados. El alcohólico fue objetivado como paciente "atípico y difícil" asociado a actitudes negativas y a elementos sociocognitivos de estigma. El alcoholismo femenino fue posiblemente percibido como más difícil de explicar que el alcoholismo masculino. La discusión destaca la importancia de las representaciones y identidades sociales para la formación continuada de profesionales de salud.

Patient Safety at Transitions of Care: Use of a Compulsory Electronic Reconciliation Tool in an Academic Hospital.

Medication errors are responsible for most inpatient adverse events. Medication reconciliation emerged as an effective strategy to decrease these problems, enhancing patient safety. Electronic health records with reconciliation tools could improve the process, but many aspects should be considered in order to reach expected outcomes. In this paper we analyzed how a compulsory, electronic reconciliation application was used at Hospital Italiano in Buenos Aires, through admission and discharge processes. We evaluated all medications that were reconciled during patient admission and discharge since its implementation, from February to November 2014. During that period, there were 78,714 reconciled medications regarding 37,741 admissions (2.08 reconciled medications per hospitalization), of 27,375 patients (2.88 medications per patient). At admission, 63% of medications were confirmed and the remaining were paused or deleted. At discharge, 41% of all medications were reconfirmed. In the creation of the best possible medication history, the use of an electronic reconciliation tool would clean overloaded lists, but at the same time medications could be erroneously deleted.

Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation.

Long chain acyl CoA synthetase 4 (Acsl4) is a key enzyme in steroidogenesis. It participates in steroid synthesis through of arachidonic acid release and Steroidogenic Acute Regulatory protein (StAR) induction. Acsl4 prefers arachidonic acid as substrate and acts probably as a homodimer. In steroidogenic cells, it has been demonstrated that Acsl4 is a high turnover protein located mainly in mitochondrial-associated membrane fraction (MAM) bound to other proteins and that it is newly synthesized by hormone stimulation. The synthesis of Acsl4 constitutes an early step in steroidogenesis. In the steroid synthesis process, activation of kinases plays a very important role. For this reason, the aim of this work was to study Acsl4 as a possible phosphoprotein and try to elucidate the role of its phosphorylation. We have determined for the first time that Acsl4 is a phosphoprotein whose phosphorylation is hormone-dependent. We also demonstrated that Acsl4 acts effectively as a dimer and that phosphorylation occurs after dimer formation. Studies in vitro demonstrated that Acsl4 is a substrate of both PKA and PKC and its phosphorylation by these kinases regulates its activity.

Endemic pemphigus in the Peruvian Amazon: epidemiology and risk factors for the development of complications during treatment.

BACKGROUND: Pemphigus is an autoimmune blistering disease. According to a report, in areas of endemic pemphigus foliaceus (EPF) in Peru there are cases of pemphigus vulgaris with epidemiologic, clinical and histopathologic characteristics similar to those of "endemic pemphigus vulgaris" (EPV) in Brazil. OBJECTIVES: To determine the clinical and epidemiologic characteristics of endemic pemphigus and the risk factors of patients for developing complications during treatment. METHODS: A study was carried out from July 2003 to March 2008. The study population was 60 patients with EPF and 7 patients with EPV evaluated in hospitals and clinics in the Peruvian Amazon and Lima. A multivariate analysis was carried out using binary logistic regression. RESULTS: The average age of EPF patients was 31.4 years; 55% were men; 60% presented the generalized clinical variant. Non-compliance with the treatment was seen in 57.1% of the patients. Thirty-five percent presented complications (e.g. pyodermitis and pyelonephritis) during treatment. The risk factors for developing complications during treatment were non-compliance with the treatment and having the generalized clinical form. In the EPV group, the average age was 21.7 years; 71.4% were men. All patients presented with the mucocutaneous clinical variant and the initial presentation consisted of oral mucosa lesions; 71.4% presented complications during treatment, pyodermitis being the most frequent. CONCLUSIONS: Non-compliance with the treatment and the generalized clinical form are risk factors for the development of complications during treatment of patients with EPF. Peru indeed has EPV cases with epidemiologic characteristics similar to EPF. Living in a rural area may represent a risk factor for the development of complications during treatment of patients with EPV.

Pasaje al acto, acting out y acto analítico: Variaciones de la relación sujeto-otro II / Passage to act [passage à l'acte], acting out and analytical act: Change of subject-other relations II

En este artículo se presentan los vectores principales y los avances del proyecto de investigación 2010-2012: "Transformaciones del concepto de pasaje al acto en el período de la obra de J. Lacan comprendido entre 1963 y 1980. Similitudes y diferencias con los conceptos de acto y acting out". Con el objetivo de avanzar en la precisión de la génesis, delimitación y transformaciones del concepto de pasaje al acto en la enseñanza de Lacan, indagamos aquí: 1) A partir del caso de psicosis de Lol V. Stein, al acting-out como una vicisitud transferencial, que pone a jugar lo que ha quedado suspendido, 2) Las coordenadas del pasaje al acto y del acto analítico teniendo como eje al Sujeto y su constitución en tanto resto de la escena parental, 3) Los aportes de los conceptos de pasaje al acto y acto, en relación al acto creativo, tomando como ejemplo la biografía de Nijinski y 4) Las diferencias entre pasaje al acto y acto, que nos permiten sostener al pasaje al acto como un concepto que conserva a lo largo del pensamiento lacaniano un valor clínico transestructural que el concepto de acto no diluye.

This article presents the main vector and the irst steps of the research project 2010-2012: "Transformation of the concept of passage to the act [passage à l'acte] during the period of the work of J. Lacan from 1963 to 1980. Similarities and differences with the concepts of act and acting out". With the goal of progress in the precisions of the origins, definition and transformation of the passage to the act [passage à l'acte] concept of in the Lacan works, we develop here: 1) The acting out involved in Lol V. Stein as transferential vicissitud that brings into play what has been suspended, 2) The the passage to the act and the analytic act coordinates having as axis the Subject and its constitution as the parental scene rest 3) The contributions of the concepts passage to act and act in relation to the creative act, taking as example the Nijinsky biography, and 4) The differences between the and passage to the act, allowing to hold the passage to the act as a concept that preserves along the Lacanian thought its transestructural clinical value that the act concept does not disolve.

Endemic pemphigus in the peruvian Amazon: epidemiology and risk factors for the development of complications during treatment / Pênfigo endêmico na Amazônia peruana: epidemiologia e fatores de risco para o desenvolvimento de complicações durante o tratamento

BACKGROUND: Pemphigus is an autoimmune blistering disease. According to a report, in areas of endemic pemphigus foliaceus (EPF) in Peru there are cases of pemphigus vulgaris with epidemiologic, clinical and histopathologic characteristics similar to those of "endemic pemphigus vulgaris" (EPV) in Brazil. OBJECTIVES: To determine the clinical and epidemiologic characteristics of endemic pemphigus and the risk factors of patients for developing complications during treatment. METHODS: A study was carried out from July 2003 to March 2008. The study population was 60 patients with EPF and 7 patients with EPV evaluated in hospitals and clinics in the Peruvian Amazon and Lima. A multivariate analysis was carried out using binary logistic regression. RESULTS: The average age of EPF patients was 31.4 years; 55% were men; 60% presented the generalized clinical variant. Non-compliance with the treatment was seen in 57.1% of the patients. Thirty-five percent presented complications (e.g. pyodermitis and pyelonephritis) during treatment. The risk factors for developing complications during treatment were non-compliance with the treatment and having the generalized clinical form. In the EPV group, the average age was 21.7 years; 71.4% were men. All patients presented with the mucocutaneous clinical variant and the initial presentation consisted of oral mucosa lesions; 71.4% presented complications during treatment, pyodermitis being the most frequent. CONCLUSIONS: Non-compliance with the treatment and the generalized clinical form are risk factors for the development of complications during treatment of patients with EPF. Peru indeed has EPV cases with epidemiologic characteristics similar to EPF. Living in a rural area may represent a risk factor for the development of complications during treatment of patients with EPV.

FUNDAMENTOS: O pênfigo é uma doença auto-imune bolhosa. Segundo um relatório, em áreas de pênfigo foliáceo endêmico no Peru há casos de pênfigo vulgar com características epidemiológicas, clínicas e histopatológicas semelhantes às do "pênfigo vulgar endêmico" no Brasil. OBJETIVOS: Determinar as características clínicas e epidemiológicas do pênfigo endêmico e os fatores de risco para o desenvolvimento de complicações durante o tratamento. MÉTODOS: Um estudo foi realizado de julho de 2003 a março de 2008. 60 doentes de pênfigo foliáceo endêmico e 7 de pênfigo vulgar endêmico foram avaliados em hospitais e clínicas na Amazônia peruana e em Lima. Uma análise multivariante foi feita usando regressão logística binária. RESULTADOS: A idade média dos doentes de pênfigo foliáceo endêmico foi 31,4 anos; 55% eram homens, 60% apresentavam a forma clínica generalizada. 57,1% nao cumpriram o tratamento. 35% apresentaram complicações (por exemplo, piodermites e pielonefrite). Os fatores de risco foram não cumprir o tratamento e ter a forma clínica generalizada. No grupo pênfigo vulgar endêmico, a idade média foi 21,7 anos; 71,4% eram homens. Todos os pacientes apresentavam a variante clínica mucocutânea e a apresentação inicial consistia de lesões da mucosa bucal; 71,4% apresentaram complicações durante o tratamento, piodermites sendo a mais freqüente. CONCLUSÕES: Não cumprir o tratamento e ter a forma clínica generalizada são fatores de risco para o desenvolvimento de complicações durante o tratamento de pênfigo foliáceo endêmico. Peru realmente tem casos de pênfigo vulgar endêmico com características epidemiológicas semelhantes às do pênfigo foliáceo endêmico. Viver numa área rural pode ser um fator de risco para o desenvolvimento de complicações.

Pasaje al acto, acting out y acto analítico: Variaciones de la relación sujeto-otro II / Passage to act [passage O lacte], acting out and analytical act: Change of subject-other relations II

En este artículo se presentan los vectores principales y los avances del proyecto de investigación 2010-2012: "Transformaciones del concepto de pasaje al acto en el período de la obra de J. Lacan comprendido entre 1963 y 1980. Similitudes y diferencias con los conceptos de acto y acting out". Con el objetivo de avanzar en la precisión de la génesis, delimitación y transformaciones del concepto de pasaje al acto en la enseñanza de Lacan, indagamos aquí: 1) A partir del caso de psicosis de Lol V. Stein, al acting-out como una vicisitud transferencial, que pone a jugar lo que ha quedado suspendido, 2) Las coordenadas del pasaje al acto y del acto analítico teniendo como eje al Sujeto y su constitución en tanto resto de la escena parental, 3) Los aportes de los conceptos de pasaje al acto y acto, en relación al acto creativo, tomando como ejemplo la biografía de Nijinski y 4) Las diferencias entre pasaje al acto y acto, que nos permiten sostener al pasaje al acto como un concepto que conserva a lo largo del pensamiento lacaniano un valor clínico transestructural que el concepto de acto no diluye.(AU)

This article presents the main vector and the irst steps of the research project 2010-2012: "Transformation of the concept of passage to the act [passage O lacte] during the period of the work of J. Lacan from 1963 to 1980. Similarities and differences with the concepts of act and acting out". With the goal of progress in the precisions of the origins, definition and transformation of the passage to the act [passage O lacte] concept of in the Lacan works, we develop here: 1) The acting out involved in Lol V. Stein as transferential vicissitud that brings into play what has been suspended, 2) The the passage to the act and the analytic act coordinates having as axis the Subject and its constitution as the parental scene rest 3) The contributions of the concepts passage to act and act in relation to the creative act, taking as example the Nijinsky biography, and 4) The differences between the and passage to the act, allowing to hold the passage to the act as a concept that preserves along the Lacanian thought its transestructural clinical value that the act concept does not disolve.(AU)

Pasaje al acto, acting out y acto analítico: Variaciones de la relación sujeto-Otro / Passage to act [passage à l'acte], acting out and analytical act: Change of subject-Other relations

En este artículo se presentan los vectores principales y los primeros avances del proyecto de investigación 2010-2012: "Transformaciones del concepto de pasaje al acto en el período de la obra de J. Lacan comprendido entre 1963 y 1980. Similitudes y diferencias con los conceptos de acto y acting out". Con el objetivo de avanzar en la precisión de la génesis, delimitación y transformaciones del concepto de pasaje al acto en la enseñanza de Lacan, indagamos aquí: 1) las coordenadas del Otro en el acting out; 2) los elementos concernidos en la formulación de un acto analítico; 3) las condiciones del pasaje al acto del famoso caso de Jean Claude Romand en su relación con la impostura y la metira y 4) las articulaciones entre los conceptos de pasaje al acto, acting-out y acto tomando como eje algunos de los usos que Lacan hace del término de locura.

This article presents the main vector and the irst steps of the research project 2010-2012: "Transformation of the concept of passage to the act [passage à l'acte] during the period of the work of J. Lacan from 1963 to 1980. Similarities and differences with the concepts of act and acting out". With the goal of advancing on the precision of the origins, definition and transformation of the concept of passage to the act [passage à l'acte] in the teaching of Lacan, we investigated here: 1) the coordinates of the Other in the acting out, 2) the elements involved in the formulation of an analytical act, 3) the conditions of the famous Jean Claude Romand case of passage to the act in relation to the imposture and lie, and 4) the joints between the concepts of passage to the act, acting out and act taking as axis some Lacan uses of the term of madness.

La locura y sus versiones en la obra de J. Lacan II: locura y psicosis / The madness and his versions in the J. Lacan work's II: madness and psychosis

Este trabajo presenta parte de las conclusiones del proyecto de investigación UBACyT P601: "Variaciones del concepto de locura en la obra de J. Lacan. Su incidencia en el diagnóstico diferencial neurosis-psicosis", aprobado y financiado para el período 2008-2010. Se aborda especialmente la cuestión problemática de su delimitación conceptual en la obra de Lacan, en la cual el término locura es empleado de diversos modos. Esta variedad se plasma en su articulación con distintos conceptos y con problemas clínicos de diversa índole. La presentación conjunta de estos usos permite obtener una visión bastante amplia de las ventajas que trae servirse de alguna de las versiones de la locura que se presentan en la obra de Lacan. En este trabajo se aplican a la articulación locura-psicosis, abordando no sólo la problemática conceptual en juego en lo atinente a alcanzar una definición más precisa de "locura", sino sobre todo el agudo problema clínico que presentan lo que podríamos designar "psicosis enloquecidas".

This paper presents some of the conclusions of the research project UBACyT P601: "Variations of the concept of madness in the work of J. Lacan. Its incidence in the differential diagnosis neurosis psychosis ", approved and funded for the period 2008-2010. It especially addresses the problematic issue of its conceptual delimitation in the Lacan work, in which the term "madness" is used in several senses. This variety is reflected in its theoretical concept articulation and several clinical issues. The whole presentation of these work allows a wider vision of the benefits that brings to use any of the versions of "madness" concept that arise in the work of Lacan. This work apply to the madness-psychosis articulation, addressing not only the conceptual issues, but also achieving a more precise definition of "madness"; and above of all it takes the big clinical problem in what we might call "mad psychosis".

Influence of climatic factors on the medical attentions of dermatologic diseases in a hospital of Lima, Peru.

BACKGROUND: Significant associations have been described between climatic factors and human health, which can occur in dermatologic diseases too. OBJECTIVE: To determine the influence of the climatic factors on the medical attentions of dermatologic diseases in a general hospital in Lima (Peru). PATIENTS AND METHODS: Observational study which was carried out in a national hospital between January 2004 and December 2007. The diagnoses were classified according to the ICD-10 system. The climate information was provided by the National Oceanographic and Atmospheric Administration from USA(NOAA). RESULTS: 3 294 patients were included in the study, the average age was 35.4 ± 20.7 years old, and 53.2% were females. The "El Niño" phenomenon was associated with an increase in the prevalence of actinic keratosis (p=0.002), viral warts (p=0.001) and rosacea (p=0.014). The "La Niña" phenomenon was associated with a reduction in viral warts (p=0.026). Spring was associated with an increase of dermatitis (p=0.003), and summer was associated with an increase of benign neoplasms (p=0.049). CONCLUSION: The climatic variations influenced the occurrence of certain dermatologic diseases. The present study may represent an orientation guide to specialists and general practitioners identifying the most common dermatologic diagnoses and thus enabling better preparation to treat these cases in determined seasons of the year.

Influence of climatic factors on the medical attentions of dermatologic diseases in a hospital of Lima, Peru / Influência de fatores climáticos no tratamento médico de doenças dermatológicas em um hospital em Lima, Peru

BACKGROUND: Significant associations have been described between climatic factors and human health, which can occur in dermatologic diseases too. OBJECTIVE: To determine the influence of the climatic factors on the medical attentions of dermatologic diseases in a general hospital in Lima (Peru). PATIENTS AND METHODS: Observational study which was carried out in a national hospital between January 2004 and December 2007. The diagnoses were classified according to the ICD-10 system. The climate information was provided by the National Oceanographic and Atmospheric Administration from USA(NOAA). RESULTS: 3 294 patients were included in the study, the average age was 35.4 ± 20.7 years old, and 53.2 percent were females. The "El Niño" phenomenon was associated with an increase in the prevalence of actinic keratosis (p=0.002), viral warts (p=0.001) and rosacea (p=0.014). The "La Niña" phenomenon was associated with a reduction in viral warts (p=0.026). Spring was associated with an increase of dermatitis (p=0.003), and summer was associated with an increase of benign neoplasms (p=0.049). CONCLUSION: The climatic variations influenced the occurrence of certain dermatologic diseases. The present study may represent an orientation guide to specialists and general practitioners identifying the most common dermatologic diagnoses and thus enabling better preparation to treat these cases in determined seasons of the year.

FUNDAMENTO: Associações significativas entre fatores climáticos e saúde humana têm sido descritas, inclusive na área de Dermatologia. OBJETIVO: Determinar a influência de fatores climáticos no tratamento de doenças dermatológicas em um hospital em Lima (Peru). PACIENTES E MÉTODOS: Estudo observacional realizado em um hospital em Lima entre janeiro de 2004 e dezembro de 2007. Os diagnósticos foram classificados de acordo com o sistema ICD-10. Informações climáticas foram fornecidas pela "National Oceanographic and Atmospheric Administration" (NOAA - USA). RESULTADOS: 3.294 pacientes participaram do estudo. A idade media foi 35.4 ± 20.7 anos e 53,2 por cento eram mulheres. O fenômeno "El Niño" foi associado a um aumento da prevalência de queratose actínica (p=0,002), verrugas virais (p=0,001) e rosácea (p=0,014). O fenômeno "La Niña" foi associado a diminuição das verrugas virais (p=0,026). A primavera foi associada a um aumento de dermatite (p=0,003) e o verão, a um aumento de tumores benignos (p=0,049). CONCLUSÃO: Variações climáticas influenciam o aparecimento de algumas doenças dermatológicas. O presente trabalho pode orientar especialistas e clínicos gerais por meio da identificação dos diagnósticos dermatológicos mais comuns e, consequentemente, prepará-los para tratar doenças sazonais.

La locura en la obra de Lacan: articulaciones con las nociones de cuerpo, manía y sexuación / Madness in the Lacan work's: joints with the body, mania and sexuation

En este artículo se presentan algunos avances del proyecto de investigación P601 (2008-2010): "Variaciones del concepto de locura en la obra de J. Lacan. Su incidencia en el diagnóstico diferencial neurosis-psicosis". Con el objetivo de avanzar en la precisión de la formalización del concepto de locura en la enseñanza de Lacan, su traducción en términos clínicos, y ponderar el modo en que dicha formalización reordena las concepciones de la locura desplegadas anteriormente en la psiquiatría y el psicoanálisis, indagamos aquí la relación de la locura con los conceptos de cuerpo, manía y sexuación.

We present in this work the state and forward of the project UBACyT 2008-2010 (P601): "Variations of the concept of madness in the work of J. Lacan. Its incidence in the diagnosis differential neurosis-psychosis". With the goal of specify the formalization of the madness concept in Lacan's work, its translation in clinical terms, and analyse the way in which this formalization reorganizes the previous conceptions of madness developed in psychiatry and psychoanalysis, we investigate here the relation of madness with the concepts of body, mania and sexuation.

Sensibilidade do diferencial semântico na caracterizaçäo de termos previamente classificados como designadores de diferentes intensidades de alguns estados subjetivos / Sensibility of the semantic differential in the characterization of terms previously classified as indicators of different intensities of selected subjective states

Foi testada a sensibilidade do Diferencial Semântico (DS) em relaçäo a variaçöes de intensidade de um mesmo estado subjetivo. Universitários de 1§ ano (161 Ss) receberam uma folha com 10 grupos de palavras sinônimas. De cada grupo deveriam selecionar três palavras usando um duplo critério: as de uso mais freqüente e que, simultaneamente, representassem níveis de intensidade fraco, médio e intenso do estado subjetivo designado. As palavras resultantes desta primeira fase foram reavaliadas, dois meses depois, por 146 Ss da mesma amostra, utilizando-se a versäo modificada do DS descrita por Engelmann. Os resultados mostram que o DS foi sensível a variaçöes de intensidade. O grau de atribuiçäo de uma característica a um determinado estado subjetivo varia se o termo que o designa representa uma ou outra intensidade desse estado. Säo feitas consideraçöes metodológicas sobre as vantagens de se utilizar palavras que designam diferentes intensidades dos estados subjetivos avaliados em estudos deste tipo

Plasma cholesterol levels in eviscerated rats

Se utilizaron en este trabajo modelos experimentales consistentes en ratas evisceradas con hígado funcional y cuyos riñones o páncreas podían dejarse in situ o resecarse. La remoción del tracto gastrointestinal resultó en una elevación significativa de los niveles plasmáticos de colesterol. En ausencia del hígado el colesterol esterificado disminuyó. La esterificación es primariamente una función hepática, ya que la ausencia de riñón no afectó este parámetro. Sólo en presencia de páncreas, hígado y riñones funcionales se observó una recuperación completa de los niveles circulantes de colesterol de ratas evisceradas. Estos resultados indican que la ausencia del tracto gastrointestinal no modifica significativamente los niveles plasmáticos de colesterol, y que los reguladores principales del metabolismo del colesterol son el hígado y el páncreas endocrino

Plasma cholesterol levels in eviscerated rats

Se utilizaron en este trabajo modelos experimentales consistentes en ratas evisceradas con hígado funcional y cuyos riñones o páncreas podían dejarse in situ o resecarse. La remoción del tracto gastrointestinal resultó en una elevación significativa de los niveles plasmáticos de colesterol. En ausencia del hígado el colesterol esterificado disminuyó. La esterificación es primariamente una función hepática, ya que la ausencia de riñón no afectó este parámetro. Sólo en presencia de páncreas, hígado y riñones funcionales se observó una recuperación completa de los niveles circulantes de colesterol de ratas evisceradas. Estos resultados indican que la ausencia del tracto gastrointestinal no modifica significativamente los niveles plasmáticos de colesterol, y que los reguladores principales del metabolismo del colesterol son el hígado y el páncreas endocrino (AU)