Physical activity levels in patients with chronic venous insufficiency.

BACKGROUND: Increasing the levels of physical activity (PA) is widely recommended for people with chronic venous insufficiency (CVI). However, studies investigating the patterns of PA and adherence to PA guidelines using objective measures are lacking. OBJECTIVE: The primary aim was to examine the patterns of PA and adherence to PA guidelines among patients with CVI. A secondary aim was to identify whether adherence to PA recommendations differed according to patients' sociodemographic and clinical characteristics. METHODS: This cross-sectional study included 96 patients with CVI with Clinical-Etiology-Anatomy-Pathology (CEAP) C3 to C6 (69.1% women 59 ± 11 years; 51.5% C5-C6 on CEAP classification). Objective time spent in PA was measured by a triaxial accelerometer. To examine adherence to PA guidelines, patients were grouped as meeting (or) the recommendations if they had at least 150 min/week of moderate to vigorous PA. Sociodemographic and clinic characteristics were obtained by self-report. Binary logistic regression was employed to examine whether sociodemographic and clinical characteristics were associated with adherence to PA guidelines. T-tests were employed to compare PA levels at different intensities according to patients' age. RESULTS: Patients spent an average of 311.4 ± 91.5 min/week, 42.1 ± 28.0 min/week, and 19.8 ± 17.8 min/week in low-light PA, high-light PA, and moderate-to-vigorous PA, respectively. The proportion of patients meeting PA recommendations was 36.2%, and older patients had lower odds (OR = 0.94; 95%CI: 0.89 to 0.99). Additional analysis reinforced that by showing lower time in high-light PA (51.2 ± 30.0 min/day vs. 31.9 ± 21.8 min/day; p = .001) and moderate-to-vigorous PA (24.3 ± 15.8 min/day vs. 14.8 ± 18.8 min/day; p = .012) among older patients than their peers younger. CONCLUSION: Our findings showed that 36,2% of CVI patients met PA recommendations, with lower odds found among older patients. Public health interventions to enhance PA engagement among CVI patients should prioritize those who are older.

Educational technology to promote self-efficacy in newborn care: a validation study.

Objective: To build and validate an educational technology consisting of a flipchart to promote self-efficacy in newborn care. Methods: A methodological study was carried out in two stages: (i) creation of the flipchart and (ii) validation by 25 experts and 50 people who could be the target audience (pregnant women, mothers or family members of newborns). Clarity, language, practical relevance and theoretical relevance were reviewed using the Suitability Assessment of Materials (SAM) instrument. The Content Validity Index and the Flesch Readability Index were calculated. Results: The serial album "Can you take care of your baby" consists of 30 pages. The overall Content Validity Index was 0.93 among experts and 1.0 among the target audience. The flipchart was considered superior quality material, reaching an agreement percentage of 94.9, indicating that it is suitable as an educational technology. Participants suggested adjustments, incorporated into the material for printed production. Conclusion: The flipchart developed and with content validated by experts is suitable for use in health education activities that aim to promote self-efficacy in caring for newborns.

Clustering of 24H movement behaviors associated with clinic blood pressure in older adults: a cross-sectional study.

Physical activity (PA), sedentary behavior (SB), and sleep duration are known to have an individual effect on clinic blood pressure (BP) of older adults. However, whether different patterns of these so-called movement behaviors over the 24h-cycle on BP remains poorly investigated. The study aimed to identify movement behavior patterns associated with clinic BP among older adults with chronic diseases. Cross-sectional study with 238 older adults (80.3% female; mean age 68.8 ± 6.6) with at least one chronic disease. PA, SB, and sleep duration were measured by a triaxial accelerometer. Clinic systolic BP (SBP) and diastolic BP (DBP) were obtained through an automated method following standard procedures. Non-hierarchical K-means cluster and linear regression modeling were employed to identify the clusters of movement behaviors and to examine the associations. Two clusters were identified [active and non-sedentary, n = 103 (i.e., sufficient sleep duration, higher LPA and MVPA, and lower SB) and sedentary and inactive, n = 135 (i.e., sufficient sleep duration, lower LPA and MVPA, and higher SB). Active and non-sedentary older adults presented lower systolic BP compared to sedentary and inactive ones, even after adjustments for sociodemographic and clinical characteristics (ß = 6.356; CI 95% from 0.932 to 11.779; P = 0.022). No associations were found for diastolic BP. In conclusion, higher PA and lower SB were associated with lower systolic BP in older adults with chronic diseases. However, sleep duration did not modify this association. Therefore, interventions focusing on concomitantly increasing PA levels and reducing SB should be the priority for controlling blood pressure.

The histamine H4 receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with growing incidence worldwide. Our group reported the compound 5-choro-1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine (LINS01007) as H4R antagonist (pKi 6.2) and therefore the effects and pharmacological efficacy on a DSS-induced mice model of UC were assessed in this work. Experimental acute colitis was induced in male BALB/c mice (n = 5-10) by administering 3 % DSS in the drinking water for six days. The test compound LINS01007 was administered daily i.p. (5 mg/kg) and compared to control group without treatment. Body weight, water and food consumption, and the presence of fecal blood were monitored during 7-day treatment period. The levels of inflammatory markers (PGE2, COX-2, IL-6, NF-κB and STAT3) were also analyzed. Animals subjected to the acute colitis protocol showed a reduction in water and food intake from the fourth day (p < 0.05) and these events were prevented by LINS01007. Histological signs of edema, hyperplasia and disorganized intestinal crypts, as well as neutrophilic infiltrations, were found in control mice while these findings were significantly reduced in animals treated with LINS01007. Significant reductions in the levels of PGE2, COX-2, IL-6, NF-κB and STAT3 were observed in the serum and tissue of treated animals. The results demonstrated the significant effects of LINS01007 against DSS-induced colitis, highlighting the potential of H4R antagonism as promising treatment for this condition.

Parent training for disruptive behavior symptoms in attention deficit hyperactivity disorder: a randomized clinical trial.

Background: Attention-Deficit/Hyperactivity Disorder (ADHD) affects 5% of children and 2.5% of adults worldwide. Comorbidities are frequent, and Oppositional Defiant Disorder (ODD) reaches 50%. Family environment is crucial for the severity of behaviors and for prognosis. In middle-income countries, access to treatment is challenging, with more untreated children than those under treatment. Face-to-face behavioral parent training (PT) is a well-established intervention to improve child behavior and parenting. Method: A clinical trial was designed to compare PT-online and face-to-face effects to a waiting list group. Outcomes were the ADHD and ODD symptoms, parental stress and styles, and quality of life. Families were allocated into three groups: standard treatment (ST), ST + PT online, and ST + Face-to-Face PT. We used repeated measures ANOVA for pre × post treatment analysis corrected for multiple comparisons. Results and discussion: Parent training was effective in reducing symptoms of ADHD (p = 0.030) and ODD (p = 0.026) irrespective of modality (p = 1.000). The combination of ST and PT was also associated with better quality of life in the physical domain for patients (p = 0.009) and their parents (p = 0.050). In addition to preliminary data, online intervention seems effective for parenting and improving social acceptance of children. The potential to reach many by an online strategy with a self-directed platform may imply effectiveness with a low cost for public health to support parents' symptoms management.

Uso de tecnologias baseadas em realidade virtual e aumentada na saúde e enfermagem: revisão integrativa

Objetivo: Determinar o uso de tecnologias baseadas em realidade virtual ou realidade aumentada na área da saúde para a população em geral. Material e Método: Revisão integrativa realizada nas bases de dados MEDLINE/PubMed, CINAHL, LILACS, Web of Science e Scopus. Foram incluídos artigos completos, sem recorte temporal, em português, inglês e espanhol que respondessem à questão norteadora. Resultados: Foram incluídos 65 estudos. As principais finalidades do uso de tecnologias baseadas em realidade virtual ou realidade aumentada foram: alívio da dor, da ansiedade e do medo; educacional (simulação e orientação); reabilitação e neurorreabilitação; promoção da saúde mental/ bem-estar psicológico; auxílio em procedimentos e apoio ao planejamento/cirurgia pré-operatória. Conclusão: Destacamos o amplo uso dessas tecnologias na área da saúde e como elas têm se mostrado benéficas em diferentes contextos clínicos, favorecendo a promoção, a prevenção e a reabilitação da saúde da população.

Objective: To determine the use of technologies based on virtual reality or augmented reality in the area of health for the general population. Material and Method: Integrative review conducted in MEDLINE/ PubMed, CINAHL, LILACS, Web of Science and Scopus databases. Full articles were included, without time frame, in Portuguese, English and Spanish that answered the guiding question. Results: 65 studies were included. The main purposes of the use of virtual reality or augmented reality-based technologies were: pain, anxiety and fear relief; educational (simulation and guidance); rehabilitation and neurorehabilitation; promoting mental health/psychological well-being; assisting in procedures and supporting preoperative planning/surgery. Conclusion: We highlight the wide use of these technologies in the health area and how beneficial they have proven to be in different clinical contexts, favoring the promotion, prevention and rehabilitation of the population's health.

Objetivo: Determinar el uso de tecnologías basadas en realidad virtual o realidad aumentada en el área de la salud para la población general. Material y Método: Revisión integrativa realizada en las bases de datos MEDLINE/PubMed, CINAHL, LILACS, Web of Science y Scopus. Se incluyeron artículos completos, sin marco temporal, en portugués, inglés y español que respondieron a la pregunta orientadora. Resultados: Se incluyeron 65 estudios. Los principales propósitos del uso de tecnologías basadas en realidad virtual o realidad aumentada fueron: alivio del dolor, la ansiedad y el miedo; carácter educativo (simulación y orientación); rehabilitación y neurorrehabilitación; promover la salud mental/bienestar psicológico; ayudar en procedimientos y apoyo a la planificación/cirugía preoperatoria. Conclusión: Se resalta el amplio uso de estas tecnologías en el área de la salud y lo beneficiosas que han demostrado ser en diferentes contextos clínicos, favoreciendo la promoción, prevención y rehabilitación de la salud de la población.

Cross-cultural adaptation, validity, and reliability of the Child and Adolescent Behavior Inventory (CABI) for use in Brazil.

OBJECTIVE: The Child and Adolescent Behavior Inventory (CABI) is a cost-free 75 question-questionnaire developed by an Italian group to collect information from parents on the behavior of children and adolescents aged 6 to 18 years. It assesses different areas of children's behavior and psychopathology, including internalizing and externalizing symptoms, and can be used to identify children at risk of mental disorders both in clinical and epidemiological settings. In this study, the authors present a Brazilian-Portuguese adaptation of the CABI and its psychometric properties. METHODS: First, the authors conducted a rigorous transcultural adaptation of CABI's questions and instructions for the Brazilian context. In an online sample of 598 parents, the authors found high reliability (internal consistency) for the CABI's main subscales. RESULTS: Validity was supported by exploratory factor analysis (the authors found 6 factors representing several aspects of psychopathology both according to the DSM and HiTop models) and significant differences in most CABI's subscales between children with parent-reported psychopathology and typically developing ones. The present study suggests that the adapted version of CABI is a valid and reliable measure that can be used in Brazil. CONCLUSIONS: The CABI can be useful to the pediatrician to get fast but wide information from parents on the behavioral condition of their children or adolescents, and also to decide whether it is appropriate to consult a mental health professional.

Prevalence and Sociodemographic Correlates of Meeting the 24-Hour Movement Guidelines Among Low-Income Brazilian Older Adults With Chronic Diseases.

This study examined the prevalence and sociodemographic correlates of meeting individual behavior and 24-hr movement behavior guidelines among Brazilian older adults with chronic diseases. The sample comprised 273 older adults aged ≥60 years (80.2% women) with chronic diseases from Recife, Pernambuco, Brazil. Sociodemographic variables were self-reported, while 24-hr movement behaviors were assessed by accelerometry. Participants were classified as meeting (or not meeting) individual and integrated recommendations for moderate-to-vigorous physical activity (MVPA), sedentary behavior, and sleep duration. No participant met the 24-hr movement behavior guidelines, while only 8.4% met integrated MVPA/sleep recommendations. The prevalence of meeting recommendations of MVPA, sedentary behavior, and sleep was 28.9%, 0.4%, and 32.6%, respectively. Discrepancies according to sociodemographic variables on meeting MVPA recommendations existed. The findings show the need for dissemination and implementation strategies to foster adoption of the 24-hr movement behavior guidelines among Brazilian older adults with chronic diseases.

Physical activity, sedentary behavior and sleep measured by smartwatch: a scoping review protocol / Atividade física, comportamento sedentário e sono medidos por smartwatch: protocolo de revisão de escopo

The health impacts of physical activity (PA), sedentary behavior (SB), and sleep are well established; thereby, the identification of instruments to assess and monitor these behaviors at a populational lev-el is relevant. In this context, smartwatches, which are wristwatch-shaped devices equipped with sen-sors, have been identified as alternatives for objectively measuring PA, SB, and sleep. Therefore, this protocol aimed at describing the goals and methods of a scoping review to map the literature on the use of smartwatches to objectively measure PA, SB, and/or sleep across the lifespan (e.g., children, adolescents, adults, and elderly) and in different contexts. Studies will be included if they use smart-watches to objectively measure at least one of the behaviors (PA, SB, and sleep) in children, adoles-cents, adults, and older adults, published after 2013. No language filter will be applied. Searches will be carried out in six databases (Pubmed/Medline, Scopus, Web of Science, LILACS, IEEE Xplore Digital Library, Scielo, Health Technology Assessment Database, and Cochrane clinical trials) and two clinical trial repositories. The screening and data extraction will be performed independently by two authors who had previous experience in reviews and technologies. The synthesis of the results will follow the Joanna Briggs Institute framework for extracting the results in scoping reviews. The results can contribute to scientific progress by identifying gaps and research trends, guiding future studies, and informing companies, healthcare professionals, and the general public who use smart-watch as a measurement tool for physical activity, sedentary behavior, and sleep

Os impactos da atividade física (AF), comportamento sedentário (CS) e sono na saúde são bem estabelecidos, tornando-se relevante identificar instrumentos que permitam avaliar e monitorar esses comportamentos em nível populacional. Nesse contexto, os smartwatches, que são dispositivos em formato de relógio de pulso, com-postos por sensores, tem sido apontado como alternativa para mensurar objetivamente AF, CS e sono. Portanto, o objetivo deste protocolo foi descrever os objetivos e métodos de uma revisão de escopo para mapear a literatura científica sobre o uso de smartwatches para medir objetivamente AF, CS e/ou sono em diferentes populações e contextos. Os estudos serão incluídos se usarem smartwatches para medir objetivamente pelo menos um dos comportamentos (AF, CS e sono) em crianças, adolescentes, adultos e idosos, publicados após 2013. Nenhum filtro de idioma será aplicado. As buscas serão realizadas em sete bases de dados (Pubmed/Medline, Scopus, Web of Science, IEEE Xplore Digital Library, Scielo, LILACS, Health Technology Assessment Database e Cochrane Clinical Trials) e dois repositórios de ensaios clínicos. A triagem e extração dos dados serão realizadas de forma independente por dois autores com experiência prévia em revisões e tecnologias. A síntese dos resultados seguirá o framework do Joanna Briggs Institute para extração dos resultados nas revisões de escopo. Os resultados podem contribuir para o progresso científico, identificando lacunas e tendências de pesquisa, orientando futuros estudos, empresas que atuam neste mercado, profissionais de saúde e o público em geral que utilizam smartwatch como um instrumento de medição para atividade física, comportamento sedentário e sono

Gaming addiction and screen time in a context of increase of internalizing symptoms: Moderation evaluation.

Children and adolescents were largely affected by the psychosocial impact of the 2019-2022 pandemic. During this time, there was an increase in internalizing symptoms, screen and internet use, and internet addiction. However, the interaction of these variables are not fully understood in a stressful time. Here, we have a repeated cross-sectional study aiming to model internalizing symptoms' prediction depending on screen time and game addiction during the COVID-19 pandemic. Parent-reported online data were collected at three timepoints, 6 months apart from each other, from a total of 1211 participants. We found an increase in screen time, game addiction, and internalizing symptoms. Regardless of the time spent in front of screens, higher levels of game addiction were associated with higher levels of internalizing symptoms in children and adolescents. Even if participants demonstrated low screen time, if they were virtually dependent they tended to exhibit higher levels of internalizing symptoms. The same result was found in all three samples. There is a need to investigate the nature of the relationship between internet addiction and internalizing symptoms and the long lasting effects of long hours on the screen.

Dupla carreira no Brasil de 2018 a 2023: um panorama dos estudos recentes / Dual career in Brazil from 2018 to 2023: an overview of recent studies / Carrera dual en Brasil de 2018 a 2023: un panorama de los estudios recientes

RESUMO Este artigo analisou como as publicações sobre dupla carreira (DC) no Brasil abordaram esse tema conceitualmente e metodologicamente. Realizamos uma revisão narrativa dos estudos publicados entre 2018 e 2023, e os analisamos a partir dos tipos de abordagens metodológicas, os conceitos e o direcionamento dessas pesquisas brasileiras. Notamos que a DC é vista como objeto de conciliação de rotinas a partir das idiossincrasias de cada grupo de investigação, carecendo de aprofundamento sobre possíveis causas para má gestão das agendas do estudante-atleta. Sugerimos uma maior interação entre os grupos de pesquisa, buscando mínimos consensos entre os investigadores sobre a noção de DC tal como a adoção de métodos holísticos que auxiliem a captar a complexidade desse fenômeno social.

ABSTRACT We analyse the conceptual and methodological approaches taken by Brazilian research on the Dual Career (DC). We conducted a narrative review of published studies between 2018 and 2023; we analysed them based on the methodological approach, the concept used, and their basic premises that support research. We observe that DC is viewed as the form of combining routines by Brazilian researchers, conducting debate from their theoretical perspectives. Still, we note little engagement among these researchers to provide a combination approach to deep knowledge about DC and their issues with managing student-athletes schedules. So, we suggest more interaction among Brazilian research groups, seeking consensus to adopt holistic research methods that aid in understanding the DC complexity.

RESUMEN Ese artículo analizó cómo las recientes publicaciones se acercaron conceptual y metodológicamente a la Carrera Dual (CD) en Brasil. Revisamos los artículos desde 2018 a 2023, y los analizamos a través de sus metodologías, conceptos y premisas teóricas que los basaron los investigadores. Observamos que la CD fue acercada como la manera de compaginar rutinas y los investigadores conducían al debate desde sus perspectivas teóricas. También notamos poco involucro entre los investigadores, lo que puede limitar la interpretación a cerca de la CD y la manera de compaginar a las agendas de los estudiantes-deportistas. Por lo tanto, sugerimos una interacción entre los investigadores brasileños, buscando acuerdos para adoptar metodologías holísticas para comprender el fenómeno de la CD.

Disruption of Atrial Rhythmicity by the Air Pollutant 1,2-Naphthoquinone: Role of Beta-Adrenergic and Sensory Receptors.

The combustion of fossil fuels contributes to air pollution (AP), which was linked to about 8.79 million global deaths in 2018, mainly due to respiratory and cardiovascular-related effects. Among these, particulate air pollution (PM2.5) stands out as a major risk factor for heart health, especially during vulnerable phases. Our prior study showed that premature exposure to 1,2-naphthoquinone (1,2-NQ), a chemical found in diesel exhaust particles (DEP), exacerbated asthma in adulthood. Moreover, increased concentration of 1,2-NQ contributed to airway inflammation triggered by PM2.5, employing neurogenic pathways related to the up-regulation of transient receptor potential vanilloid 1 (TRPV1). However, the potential impact of early-life exposure to 1,2-naphthoquinone (1,2-NQ) on atrial fibrillation (AF) has not yet been investigated. This study aims to investigate how inhaling 1,2-NQ in early life affects the autonomic adrenergic system and the role played by TRPV1 in these heart disturbances. C57Bl/6 neonate male mice were exposed to 1,2-NQ (100 nM) or its vehicle at 6, 8, and 10 days of life. Early exposure to 1,2-NQ impairs adrenergic responses in the right atria without markedly affecting cholinergic responses. ECG analysis revealed altered rhythmicity in young mice, suggesting increased sympathetic nervous system activity. Furthermore, 1,2-NQ affected ß1-adrenergic receptor agonist-mediated positive chronotropism, which was prevented by metoprolol, a ß1 receptor blocker. Capsazepine, a TRPV1 blocker but not a TRPC5 blocker, reversed 1,2-NQ-induced cardiac changes. In conclusion, neonate mice exposure to AP 1,2-NQ results in an elevated risk of developing cardiac adrenergic dysfunction, potentially leading to atrial arrhythmia at a young age.

Cross-cultural adaptation, validity, and reliability of the Child and Adolescent Behavior Inventory (CABI) for use in Brazil

Abstract Objective The Child and Adolescent Behavior Inventory (CABI) is a cost-free 75 question-questionnaire developed by an Italian group to collect information from parents on the behavior of children and adolescents aged 6 to 18 years. It assesses different areas of children's behavior and psychopathology, including internalizing and externalizing symptoms, and can be used to identify children at risk of mental disorders both in clinical and epidemiological settings. In this study, the authors present a Brazilian-Portuguese adaptation of the CABI and its psychometric properties. Methods First, the authors conducted a rigorous transcultural adaptation of CABI's questions and instructions for the Brazilian context. In an online sample of 598 parents, the authors found high reliability (internal consistency) for the CABI's main subscales. Results Validity was supported by exploratory factor analysis (the authors found 6 factors representing several aspects of psychopathology both according to the DSM and HiTop models) and significant differences in most CABI's subscales between children with parent-reported psychopathology and typically developing ones. The present study suggests that the adapted version of CABI is a valid and reliable measure that can be used in Brazil. Conclusions The CABI can be useful to the pediatrician to get fast but wide information from parents on the behavioral condition of their children or adolescents, and also to decide whether it is appropriate to consult a mental health professional.

Desafios na Atividade Laboral de Pacientes em Hemodiálise e sua Associação com a Qualidade de Vida / Work Activity Challenges among Hemodialysis Patients and Their Impact on Quality of Life

Grande parte dos pacientes em hemodiálise estão em idade laboral, acarretando um desafio na manutenção do seu trabalho. Realizou-se um estudo transversal em centros de hemodiálise no norte de Santa Catarina, entre dezembro de 2020 a fevereiro de 2021. Incluiu-se pacientes entre 18 e 55 anos em hemodiálise há mais de 3 meses. Avaliou-se aspectos relacionados ao trabalho, sua manutenção após início da hemodiálise e a qualidade de vida através do instrumento SF-36. A condição laboral foi avaliada com relação a qualidade de vida através de regressão logística. Dos 108 pacientes, a média de idade foi 43,34 ±8,88 anos, com mediana do tempo em diálise de 19 meses. Dos participantes, 78,9% estavam trabalhando seis meses antes do início da hemodiálise e 39,8% após 6 meses. Não houve diferença em relação ao sexo, idade e estado civil com relação ao trabalho antes ou após 6 meses do início da hemodiálise. Trabalhar foi associado a uma maior qualidade de vida, mesmo após ajuste para outras variáveis (OR=5,30; 95% IC 1,43-19,61, p=0,013). Conclui-se que existe importante queda da manutenção do emprego após início da hemodiálise. O estímulo a manutenção do trabalho pode favorecer uma melhor qualidade de vida nestes pacientes.

Most patients undergoing hemodialysis are of working age, and this poses a challenge in maintaining their jobs. A crosssectional study was carried out in hemodialysis centers in the north of Santa Catarina, between December 2020 and February 2021. Patients aged between 18 and 55 years old on hemodialysis for more than 3 months were included. Aspects related to work, remaining at their job after starting hemodialysis, and quality of life were evaluated using the SF-36 instrument. Their working situation was evaluated in relation to quality of life through logistic regression. Of the 108 patients, the mean age was 43.34 ± 8.88 years old, with a median time on dialysis of 19 months. Of the participants, 78.9% were working six months before starting hemodialysis and 39.8% were working 6 months after. There was no difference in terms of sex, age, and marital status with regards to work before or after 6 months of starting hemodialysis. Working was associated with a better quality of life, even after adjusting for other variables (OR=5.30; 95% CI 1.43-19.61, p=0.013). It is concluded that there is a significant drop in employment after starting hemodialysis. The stimulus to keep working can favor a better quality of life in these patients.

Influência das variantes genéticas do gene IL6 no transtorno depressivo maior: uma revisão / nfluence of IL6 gene genetic variants on major depressive disorder: a review / Influencia de las variantes genéticas del gen IL6 en el trastorno depresivo mayor: una revisión

Objetivo:Elucidar o quadro clínico do transtorno depressivo maior (TDM) e verificar a associação dessa condição com polimorfismos do gene IL6. Método:Tratou-se de uma revisão sistemática com a busca de artigos originais nas bases de dados Scopus, Web of Science, PubMed e BVS, os quais trouxeram informações sobre variantes genéticas que tinham relação com polimorfismos do gene IL6. Estudos que não apresentaram dados completos, inclusive dados estatísticos, revisões, meta-análises e resumos, foram excluídos. Resultados:Foram encontrados 54 artigos nas bases de dados. Utilizou-se a plataforma Rayyan para retirar as duplicatas e ler os resumos para seleçãoinicial. Restaram 12 artigos, onde os que eram de acesso livre foram encaminhados para leitura completa, totalizando 5 artigos para essa revisão. Conclusão:Evidências sugerem uma condição sistêmica no TDM e dados demonstram alterações inflamatórias. Dadoque na maior parte dos estudos pacientes com TDM tiveram estados inflamatórios mais elevados, parece haver relação entre a IL-6 e o transtorno. A IL-6 induz alterações no cérebro, ativação de microglia e controla a saúde dos neurônios, podendo tornar tangível uma relação dos polimorfismos com a doença, mas ainda não existem muitos estudos na área

Objective:To elucidate the clinical picture of major depressive disorder (MDD) and to verify the association of this condition with polymorphisms of the IL6 gene. Method:This was a systematic review with the search of original articles in the databases Scopus, Web of Science, PubMed and VHL, which brought information about genetic variants that were related to polymorphisms of the IL6 gene. Studies that did not present complete data, including statistical data, reviews, meta-analyses and abstracts, were excluded. Results:A total of 54 articles were found in the databases. The Rayyan platform was used to remove the duplicates and read the abstracts for initial selection. There were 12 articles, where those that were freely accessible were sent for full reading, totaling 5 articles for this review. Conclusion:Evidence suggests a systemic condition in MDD and data demonstrate inflammatory changes. Given that in most studies patients with MDD had higher inflammatory states, there seems to be a relationship between IL-6 and the disorder. IL-6 induces changes in the brain, activation of microglia and controls the health of neurons, and may make tangible a relationship between polymorphisms and the disease, but there are not many studies in the area.

Objetivo: Dilucidar el cuadro clínico del trastorno depresivo mayor (TDM) y verificar la asociación de esta condición con polimorfismos del gen IL6. Método: Se trata de una revisión sistemática con búsqueda de artículos originales en las bases de datos Scopus, Web of Science, PubMed y BVS, que aportaron información sobre variantes genéticas relacionadas con polimorfismos del gen IL6. Se excluyeron los estudios que no presentaron datos completos, incluidos datos estadísticos, revisiones, metanálisis y resúmenes. Resultados:Se encontraron un total de 54 artículos en las bases de datos. La plataforma Rayyan se utilizó para eliminar los duplicados y leer los resúmenes para la selección inicial. Hubo 12 artículos, donde aquellos que eran de libre acceso fueron enviados para lectura completa, totalizando 5 artículos para esta revisión. Conclusión:La evidencia sugiere una condición sistémica en el TDM y los datos demuestran cambios inflamatorios. Dado que en la mayoría de los estudios los pacientes con TDM tenían estados inflamatorios más altos, parece haber una relación entre la IL-6 y el trastorno. La IL-6 induce cambios en el cerebro, la activación de la microglía y controla la salud de las neuronas, y puede hacer tangible una relación entre los polimorfismos y la enfermedad, pero no hay muchos estudios en el área.

Low-Load Resistance Exercise with Blood Flow Restriction Increases Hypoxia-Induced Angiogenic Genes Expression.

The aim of the study was to determine whether low-load exercise (LL) with blood flow restriction (LL-BFR) would induce similar changes in expression of genes involved in hypoxia and angiogenesis compared to LL and high-load exercise (HL). Twenty-four males (age: 21.3 ± 1.9 years, body height: 1.74 ± 0.8 m, body mass: 73 ± 1.8 kg) were allocated into three groups: low-load exercise (LL), low-load exercise with blood-flow restriction (LL-BFR), and high-load exercise (HL). For the LL-BFR group a pneumatic cuff was inflated at 80% of the arterial occlusion pressure. All participants performed bilateral knee extension exercise, twice a week, for 8 weeks. LL and LL-BFR groups performed 3-4 sets of 15 reps at 20% 1RM, whilst the HL group performed 3-4 sets of 8-10 reps at 80% 1RM with a 60-s rest interval between sets. The hypoxia-inducible factor-1 alpha (HIF-1α) and beta (HIF-1ß), vascular endothelial growth factor (VEGF), neuronal (nNOS), and inducible nitric oxide synthase (iNOS) genes expression were assessed before and after training. HIF-1α and HIF-1ß mRNA levels significantly increased in the LL-BFR group and exceeded those elicited by HL and LL groups (p < .0001). VEGF gene expression was increased in both LL-BFR and HL groups, however, LL-BFR elicited a greater increase than LL (p < .0001). nNOS and iNOS genes expression significantly increased in all groups with greatest increases being observed in the LL-BFR group (p < .0001). The findings suggest that LL-BFR induces greater increases in genes expression related to hypoxia and angiogenesis than traditional resistance training.

4th Order LC-Based Sigma Delta Modulators.

Due to the characteristic of narrow band conversion around a central radio frequency, the Sigma Delta Modulator (ΣΔM) based on LC resonators is a suitable option for use in Software-Defined Radio (SDR). However, some aspects of the topologies described in the state-of-the-art, such as noise and nonlinear sources, affect the performance of ΣΔM. This paper presents the design methodology of three high-order LC-Based single-block Sigma Delta Modulators. The method is based on the equivalence between continuous time and discrete time loop gain using a Finite Impulse Response Digital-to-Analog Converter (FIRDAC) through a numerical approach to defining the coefficients. The continuous bandpass LC ΣΔM simulations are performed at a center frequency of 432 MHz and a sampling frequency of 1.72 GHz. To the proposed modulators a maximum Signal-to-Noise Ratio (SNR) of 51.39 dB, 48.48 dB, and 46.50 dB in a 4 MHz bandwidth was achieved to respectively 4th Order Gm-LC ΣΔM, 4th Order Magnetically Coupled ΣΔM and 4th Order Capacitively Coupled ΣΔM.

Blood-Flow-Restriction-Training-Induced Hormonal Response is not Associated with Gains in Muscle Size and Strength.

The aim of this study was to determine whether increases in post-exercise endocrine response to low-load resistance exercise with blood flow restriction and high-load resistance exercise would have association with increases in muscle size and strength after an 8-week training period. Twenty-nine untrained men were randomly allocated into three groups: low-load resistance exercise with (LL-BFR) or without blood flow restriction (LL), and high-load resistance exercise (HL). Participants from LL-BFR and LL groups performed leg extension exercise at 20% of one repetition maximum (1RM), four sets of 15 repetitions and the HL group performed four sets of eight repetitions at 80% 1RM. Before the first training session, growth hormone (GH), insulin-like growth factor 1 (IGF-1), testosterone, cortisol, and lactate concentration were measured at rest and 15 min after the exercise. Quadriceps CSA and 1RM knee extension were assessed at baseline and after an 8-week training period. GH increased 15 min after exercise in the LL-BFR (p = 0.032) and HL (p < 0.001) groups, with GH concentration in the HL group being higher than in the LL group (p = 0.010). There was a time effect for a decrease in testosterone (p = 0.042) and an increase in cortisol (p = 0.005), while IGF-1 remained unchanged (p = 0.346). Both muscle size and strength were increased after training in LL-BFR and HL groups, however, these changes were not associated with the acute post-exercise hormone levels (p > 0.05). Our data suggest that other mechanisms than the acute post-exercise increase in systemic hormones induced by LL-BFR and HL produce changes in muscle size and strength.

Effects of Breaking Up Prolonged Sitting on Cardiovascular Parameters: A systematic Review.

The aim of this systematic review was to analyze the acute and chronic effects of sitting breaks on cardiovascular parameters. PubMed and Web of Science databases were searched by two independent researchers for relevant studies published until February 2020. Acute or chronic studies reporting the effects of sitting breaks or reduction in sitting time on cardiovascular parameters were examined. The eligibility criteria followed PICOS: Population - Humans ≥ 18 years old; Interventions - Sitting break strategies; Comparisons - Uninterrupted sitting; Outcomes - Cardiovascular parameters (blood pressure, heart rate, ambulatory blood pressure, vascular function, pulse-wave velocity, cerebral blood flow and biomarkers); Study design - Randomized controlled trials, non-randomized non-controlled trials and randomized crossover trials. Forty-five studies were included, where 35 investigated the acute and 10 the chronic effects of sitting breaks or reductions in sitting time. Walking was the main acute study strategy, used in different volumes (1 min 30 s to 30 min), intensities (light to vigorous) and frequencies (every 20 min to every 2 h). Acute studies found improvements on cardiovascular parameters, especially blood pressure, flow-mediated dilation, and biomarkers, whereas chronic studies found improvements mostly on blood pressure. Breaking up or reducing sitting time improves cardiovascular parameters, especially with walking.