[THE REGIONAL MATERNAL CAPITAL AND DIRECTIONS OF ITS USAGE IN THE SIBERIAN FEDERAL OKRUG].

The research institute of complex problems of hygiene and occupational diseases of the Siberian branch of of the Russian academy of medical sciences, 654041 Novokuznetsk, Russia; 2The institute of economics and organization of industrial manufacture of the Siberian branch of the Russian academy of sciences, 630090 Novosibirsk, Russia The maternal capital as a measure of stimulation of birth (adoption) of second child functions in Russia since 2007. During following years the local subventions were introduced in the form of maternal capital for birth (adoption) of third child or subsequent children. The article considers characteristics of this measure of social support in the Siberian federal okrug and possible ways of extension of practice of its application as well.

[The efficacy of using an immune lactoglobulin preparation for correcting intestinal dysbacteriosis in newborn infants]. / Effektivnost' primeneniia preparata immunnogo laktoglobulina dlia korrektsii disbakterioza kishechnika u novorozhdennykh detei.

The comparative study of the effectiveness of immune immunoglobulin and bifidumbacterin for the correction of dysbiotic microflora in the intestine of premature born children with infectious inflammatory diseases. Immune lactoglobulin was administered orally to 37 children in a dose of 500 mg/kg twice a day for 1-3 weeks. The preparation facilitated the rapid and stable normalization of disturbances in the intestinal biocenosis in 86.5% of newborns. The elimination of opportunistic lactose-negative enterobacteria, Pseudomonas aeruginosa hemolytic forms of Escherichia from the digestive tract and the stimulation of the multiplication of lactic acid bacteria were noted. The treatment of newborns with immune lactoglobulin was found to give a more pronounced corrective effect with respect of intestinal microflora than the use of bifidumbacterin according to the traditional scheme.

[The immunogenicity of mono- and associated vaccines made from strains of opportunistic bacteria]. / Izuchenie immunogennosti mono- i assotsiirovannykh vaktsin iz shtammov uslovno-patogennykh bakterii.

In experiments on white mice the immunogenic potency of two variants of combined vaccines prepared from strains of opportunistic bacteria was compared with that of monovaccines used as the components of the combined vaccines. All the vaccines under study were found highly immunogenic. Decrease of monovaccine share in the combined vaccine did not reduce the immunogenic potency to any of the strains. An 8- to 16-fold increase in the level of specific antibodies in the colostric lactosera of cows immunized with combined vaccines was observed, and the survival rate of newborn calves increased 3- to 4-fold.

[An experimental study of a lactoglobulin preparation against opportunistic bacteria and salmonellae]. / Eksperimental'noe izuchenie preparata laktoglobulina protiv uslovno-patogennykh bakterii i sal'monell.

A preclinical study of seven batches of lactoglobulin, a new biological preparation against opportunistic bacteria and salmonellae, has been carried out. High antibacterial activity of the preparation with respect to the virulent forms of Salmonella typhimurium, Salmonella enteritidis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis has been established. The preparation has been shown to be safe and nontoxic. The 4-year term of its storage at a temperature of 6 degrees +/- 4 degrees C has been substantiated.

[Prospects of using controlled-action lactoglobulins in the treatment of acute intestinal infections and dysbacteriosis in infants]. / Perspektivy primeneniia laktoglobulinov napravlennogo deistviia dlia lecheniia ostrykh kishechnykh infektsii i disbakterioza u detei rannego vozrasta.

The author summarizes the results of the preclinical study and clinical trial of the new biological drug lactoglobulin having an +anti-coli-proteus action. Shows that the drug holds promise in the treatment of infants with acute intestinal infections and dysbacteriosis as well as in the enrichment of lactic mixtures used for artificial feeding of premature children and babies referred to the risk group.

[Experimental study of a new biological preparation for treating E. coli infection and Proteus dysbacteriosis in young infants]. / Eksperimental'noe izuchenie novogo biologicheskogo preparata dlia lecheniia koli-infektsii i proteinogo disbakterioza u detei rannego vozrasta.

The action of a new biological preparation intended for the treatment of E. coli infection and Proteus dysbacteriosis in children has been studied in experiments on mice and suckling rabbits. The protective activity of anti-E. coli and anti-Proteus lactoglobulin has been found to exceed that of normal lactoglobulin 6- to 13-fold. When subjected to the action of proteolytic enzymes of the gastrointestinal tract, the preparation retains its preventive properties on the level of the native preparation, which confirms the possibility of the oral administration of the preparation in clinical practice without protecting it from the proteolytic action of the enzymes of the gastrointestinal tract.

[Experience in the use of anti-colibacillus and Proteus lactoglobulin as a supplement to milk products in diet therapy at a specialized childrens' collective]. / Opyt primenieniia protivokoliproteinogo laktoglobulina v kachestve dobavki k molochnym produktam dlia lechebnogo pitaniia v spetsializirovannom detskom kollektive.

A new biologically active supplement (BAS) for infant food was tested at an Infant's Home. BAS-IG contains lactoglobulin, an immune preparation against colibacillus and Proteus. During the primary examination of the infants in the Infant's Home intestinal dysbacteriosis was revealed in 100% of the infants, clinical signs of dysbacteriosis were detected in 88.4% of the infants. Two successive courses of feeding the infants with products enriched with the new supplement resulted in a significant improvement of the microflora composition in them and in normalizing their clinical condition. At the same time positive changes in a number of immunological factors were recorded. The authors have recommended using BAS-IG for correction of dysbacteriosis in children at Infant's Homes.