1.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 62(Pt 11): 1058-60, 2006 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17077479
RESUMO
Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity.