RESUMO
Generalized essential telangiectasia (GET) is a notoriously difficult to treat disorder with no current satisfactory treatments. This case and discussion report the use of 6-mercaptopurine (6-MP) as a successful treatment for GET. Moreover, we show that GET may represent a state of increased angiogenesis, a paradigm shift from the current understanding that these telangiectasias represent dilatations of only pre-existing vessels. This new view of GET may drive others to look at novel agents for treatment.
J Drugs Dermatol. 2017;16(3):280-282.
.Assuntos
Antimetabólitos Antineoplásicos/uso terapêutico , Colite Ulcerativa/tratamento farmacológico , Mercaptopurina/uso terapêutico , Neovascularização Patológica/urina , Telangiectasia/tratamento farmacológico , Antígenos CD34/metabolismo , Antimetabólitos Antineoplásicos/administração & dosagem , Biomarcadores/urina , Colágeno Tipo IV/metabolismo , Células Endoteliais/metabolismo , Feminino , Fibrinogênio/urina , Humanos , Lasers de Corante/uso terapêutico , Terapia com Luz de Baixa Intensidade , Mercaptopurina/administração & dosagem , Metaloproteases/urina , Pessoa de Meia-Idade , Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismo , Telangiectasia/patologia , Telangiectasia/psicologia , Telangiectasia/radioterapiaRESUMO
There is an increasing trend shifting the aesthetic focus downward from the face with a significant number of new treatments aimed at the aging neck and below. Clinical characteristics of neck youth include clear skin texture and tone without laxity or fat, in addition to a well-defined cervicomental angle and distinct mandibular border. Similarly to treating facial aging, the neck requires a comprehensive assessment of all factors involved in the aging process--loss of volume, increased skin laxity, worsening texture and clarity, and crepe skin/wrinkling--as each requires a combination approach for improvement. It is essential to address each above factors for more than minimal improvement. A multitude of options including neuromodulators, energy based devices, surgery, and injectable agents for fat reduction are available in our armamentarium and understanding these options solo, or ideally in combination, is essential for best practice and optimal results. Herein, we describe synergic approaches to the treatment of neck aging.