Immunoglobulin E to cow's-milk protein in breast-fed atopic children.

Over a 3-yr period, 18 children , ages 10 mo to 5 yr, were discovered to have IgE to cow's-milk protein (CMP). They were compared with 18 age-matched patients for having been primarily breast fed during the first 6 mo of life. All were new allergy clinic asthmatic patients with a strong family history of atopy and evidence of IgE to multiple allergens. Analysis of the data on this allergic population revealed that both a history of breast feeding and of milk-induced immediate reaction in patients with CMP-specific IgE was significantly higher (p is less than 0.03) than in those patients without IgE to CMP. Inadvertent sensitization to food antigens can occur in some atopic breast-fed infants.

Polymer distribution in human serum albumin powders prepared by lyophilization or acetone drying.

Various lots of human serum albumin, prepared by the Cohn alcohol procedure, were assayed for polymer distribution after lyophilization or acetone drying of the albumin paste. Sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that powders obtained by acetone drying of the pastes contained significantly higher amounts of monomeric albumin.