[Cytological and molecular changes in the atypical case of accelerated human aging]. / Tsitologicheskie i molekuliarnye izmeneniia pri netipichnom sluchae uskorennogo stareniia cheloveka.

A complex research of cells of a patient with unusual form of premature ageing was made. The clinical picture is not typical for any of known forms of hereditary premature aging--progerias. Skin fibroblasts of the patient AG has limited proliferation capacity in vitro. It was shown by fluorescent-immunochemical hybridization (FISH-method), that the level of stable chromosome aberrations in AG blood lymphocytes was characteristic of aged 55-65 years, though as he was only 26 years old. Some characteristic peculiarities, typical for progerias, were found in the reaction of skin fibroblasts of AG to growth factors addition. Some clinical and biochemical peculiarities are results rather, than reasons of the disease. The conclusion is that the premature ageing in this case is a manifestation of Werner's syndrome--one of hereditary forms of accelerated senescence.

[The role of molecular genetic diagnosis in prediction and prevention of age specific pathology]. / Rol' molekuliarno-geneticheskoi diagnostiki v prognozirovanii i profilaktike vozrastnoi patologii.

A method of molecular-genetic diagnosis of diseases in hereditary predisposition developed by the authors is novel in geriatric practice. It allows to predict such prevalent age-specific diseases as ischemic heart disease, hypertension, noninsulin-dependent diabetes mellitus, Alzheimer's and some malignancies. Assessment of molecular-genetic, clinical and laboratory data can identify predisposition or early symptoms of the disease. Special system of prophylaxis and pathogenetic treatment is designed to prevent development of genetically predetermined age-specific diseases.