1.
ACS Med Chem Lett
; 3(5): 387-91, 2012 May 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900483
RESUMO
An in silico screen of the NIH Molecular Library Small Molecule Repository (MLSMR) of â¼350000 compounds and confirmatory bioassays led to identification of chaetochromin A (1) as an inhibitor of botulinum neurotoxin serotype A (BoNT A). Subsequent acquisition and testing of analogues of 1 uncovered two compounds, talaroderxines A (2) and B (3), with improved activity. These are the first fungal metabolites reported to exhibit BoNT/A inhibitory activity.