Comparison of the effect of Dapagliflozin and Pioglitazone on the risk of osteoporosis in postmenopausal women with Type-2 diabetes.

Objective: Type 2 Diabetes mellitus (T2DM) and osteoporosis, which increase with age, are two common diseases with different complications. The risk of fractures due to osteoporosis is 2 to 6 times higher in patients with diabetes mellitus (DM). Medications used in the treatment of DM in addition to the disease itself are associated with the risk of osteoporosis and osteoporotic fractures. This study was planned to examine the effects of pioglitazone and dapagliflozin, used in the treatment of T2DM, on the development of osteoporosis in postmenopausal women. Methods: This single-centre comparative study was conducted at Endocrine and Metabolic Diseases Polyclinic of a Hospital between April 15, 2019 and April 15, 2020, with a total of 80 postmenopausal female patients with a diagnosis of T2DM and 20 in the control group, aged between 50 and 70. The participants were evaluated under four groups: "Control" without diabetes mellitus (n=20), "Pioglitazone" using (n=30), "Dapagliflozin" using (n=30), and "Other Oral Antidiabetic" using (n=20). Results: The mean age of the participants was 61.32±6.27 years. There was no statistically significant difference between the groups in the hip and waist T-score values of participants with T2DM in the study (p>0.05). There was no significant difference in waist and hip t-score values between the intervention groups. Pioglitazone and dapagliflozin used in postmenopausal T2DM patients were determined not to make a significant difference in waist and hip bone mineral density values. Conclusion: Our study revealed that pioglitazone and dapagliflozin can be used in postmenopausal T2DM individuals without known osteoporosis and other osteoporosis risk factors.

Assessment of Tp-Te Interval and Tp-Te/Qt Ratio in Patients with Aortic Aneurysm.

BACKGROUND: Arrhythmic disorders in the aortic aneurysm (AA) have been rarely reported. AIM: The study aimed to assess the repolarisation indices of ventricular arrhythmia (VA) (mainly Tp-Te interval and Tp-Te/QT ratio) in patients with AA. METHODS: A group of 98 patients with AA and 75 patients as control were recruited. Many of indices of ventricular arrhythmia were assessed. RESULTS: Many of indices like QT, QTc, QTpc, Tp-Te/QT, Tp-Te/QTc, Tp-Tec/QTc, S-Tp, S-Tpc, S-Te, S-Tec and fQRS were found to be significantly different in AA group (for all P < 0.05). However, QTp, mean Tp-Te and Tp-Tec were not found different (for all P < 0.05). Aortic diameter (Ao-D) was found to have a positive correlation with QTc, QTpc, S-Tp, S-Tpc, S-Te, S-Tec, fQRS (for all P < 0,05) and negative correlation withTp-Te/QT (P = 0.047). The best cut-off level for prediction of Tp-Te ≥100 ms was found the Ao-D > 43.5 mm in ROC analysis (AUC: 0.69; P = 0.151) with sensitivity 60% and specificity 79.6%. CONCLUSIONS: Although our study did not find any differences for mean Tp-Te interval between groups, many of other indexes of TDR were found to be significantly different. Ao-D was found to have significant correlations with many indices.

Comparing of Tp-Te Interval and Tp-Te/Qt Ratio in Patients with Preserved, Mid-Range and Reduced Ejection Fraction Heart Failure.

BACKGROUND: Heart failure (HF) is classified in three class: HF with preserved EF (HFpEF); normal or LVEF ≥ 50%, HF with reduced EF (HFrEF); LEVF < 40% and newly HF mid-range EF (HFmrEF); LVEF 40-49%. On Electrocardiography (ECG) T wave, Tpeak-Tend (Tp-Te) interval reflects transmural dispersion of repolarisation (TDR) which of these indexes have been proposed as predictors of risk for ventricular arrhythmia (VA) in many cardiac diseases. AIM: Aim of this study to asses these indices of TDR among three HF class. METHODS: Total of 192 patients were included in this study. RESULTS: Many of indices like Tp-Te, Tp-Te/QT wasn't different between groups (P > 0.05). But mean Q-Tpeak (QTp), S-Tend (S-Te) and S-Tpeak (S-Tp) were found significantly different between groups (P < 0.05). Again S-Te was found different according to having fragmented QRS (fQRS) on ECG (P = 0.031). Comparing to mitral inflow E/A parameters showed significant differences for Tp-Te, Tp-Tec, Tp-Te/QT, Tp-Te/QTc and Tp-Tec/QTc parameters. Finally, we found correlations between S-Te and white blood cell (WBC) (r = - 0.171; P = 0.037) and S-Tp and WBC (r = - 0.170; P = 0.038) and between S-Te and fQRS (r = 0.158; P = 0.031). CONCLUSIONS: We didn't find differences for many of indices of TDR like Tp-Te interval between groups except QTp, S-Te, S-Tp intervals. Also, S-Te and fQRS showed significant correlation. For prediction of ventricular arrhythmia and cardiovascular death newer indexes on ECG are needed to be established in the future which will make us facilitate to distinguish high risk patients.

Investigation on carbohydrate counting method in type 1 diabetic patients.

OBJECTIVE: The results from Diabetes Control and Complications Trial (DCCT) have propounded the importance of the approach of treatment by medical nutrition when treating diabetes mellitus (DM). During this study, we tried to inquire carbohydrate (Kh) count method's positive effects on the type 1 DM treatment's success as well as on the life quality of the patients. METHODS: 22 of 37 type 1 DM patients who applied to Eskisehir Osmangazi University, Faculty of Medicine Hospital, Department of Endocrinology and Metabolism, had been treated by Kh count method and 15 of them are treated by multiple dosage intensive insulin treatment with applying standard diabetic diet as a control group and both of groups were under close follow-up for 6 months. Required approval was taken from the Ethical Committee of Eskisehir Osmangazi University, Medical Faculty, as well as informed consent from the patients. The body weight of patients who are treated by carbohydrate count method and multiple dosage intensive insulin treatment during the study beginning and after 6-month term, body mass index, and body compositions are analyzed. A short life quality and medical research survey applied. At statistical analysis, t-test, chi-squared test, and Mann-Whitney U test were used. RESULTS: There had been no significant change determined at glycemic control indicators between the Kh counting group and the standard diabetic diet and multiple dosage insulin treatment group in our study. CONCLUSION: As a result, Kh counting method which offers a flexible nutrition plan to diabetic individuals is a functional method.

Eating habits, lifestyle factors, and body weight status among Turkish private educational institution students.

OBJECTIVE: The purposes of this study were to assess the prevalence of underweight, overweight, and obesity and to evaluate the effects of eating habits, lifestyle, and sociodemographic characteristics on students' weight. METHODS: This cross-sectional study was carried out from February to May 2008 in the city of Eskisehir, western Turkey. A total of 2258 students 15-20 y of age (1137 boys and 1121 girls) were examined. The questionnaires, including items related to eating habits, lifestyle, and sociodemographic characteristics, were completed by the students. The data were evaluated using chi-square test and percent ratios. In addition, Student's t test for means and reliability analysis was employed to test the reliability of the questionnaire scale. Differences were considered statistically significant at P < 0.05. RESULTS: About 70% of the students (69.9%) were of normal weight; more than one-fourth (25.7%) were underweight; and 4.4% were overweight/obese students, with just 0.6% being obese (n = 14). According to 21 of the 29 items in the questionnaire found to be positively significant, girls had more accurate habits than boys (13 versus 7 items, respectively). Compared with those underweight or of normal weight, the proportion of those overweight/obese was smaller for those having milk or juice at breakfast (P < 0.05), special meals prepared at least once daily at home (P < 0.05), and not selecting fast food such as hamburgers at meals (P < 0.01). CONCLUSION: The results of this study suggest that the prevalence of overweight and obesity is much lower than the prevalence of underweight in Turkish school-based adolescents, important data that merit consideration. Health professionals, teachers, and family environment may play a key role in the promotion of a healthy lifestyle.

Eating habits reported by secondary school students in a city of west Turkey.

OBJECTIVE: The prevalence of obesity and underweight has increased in recent years due to the fact that eating and drinking habits have changed all over the world. This survey was conducted to estimate the prevalence of both obesity and underweight, as well as to understand the eating and drinking habits of a group of Turkish students. METHODS: 1044 students completed the survey. Responses were analyzed, using Chi-square (chi2) test and percent (%) ratios, according to gender. Differences were considered significant for p<0.05. RESULTS: About 10% of the students (123/1044, 11.8%) were underweight, most of them were male. Most students (868/1044, 83.1%) were of the correct weight. A small percentage of the students (52/1044, 4.9%) were overweight, with just one obese student, boy. Compared to boys, girls significantly obtained higher scores when questioned on preference of bran bread (62.0% vs. 38.0%, respectively), taking pains to not gain excess weight in order not to get fat (55.6% vs. 44.4%, respectively), doing physical exercise if they felt they were gaining too much weight (54.85% vs. 45.2%, respectively), and reducing food consumption when they felt that they were gaining weight (55.0% vs. 45.0%, respectively). CONCLUSION: For most people the importance of diet was obvious. This was especially reflected in the females' reports, since they reported a continual increase in their dieting and exercise behavior in an attempt to attain the contemporary ideal of being thin and physically fit.

Prevalence of nonvitamin, nonmineral supplement usage among students in a Turkish university.

BACKGROUND: There have been multiple studies carried out in many countries with regard to the use of nonvitamin, nonmineral (NVNM) supplements. These studies have shown that the use of NVNM supplements is on the increase throughout the world, particularly in western countries. The aim of this study was to assess the extent of NVNM supplement use among Turkish university students. METHODS: The survey was conducted between September and December 2004 at Osmangazi University, a public university located in the west of Turkey. Responses were analysed, using the chi-square (x2) test, t test and percent (%) ratios, according to gender and consumers. Differences were considered significant for p