2D MXene Biomaterials for Catalytic Medical Applications.

In recent years, two-dimensional transition metal carbides, nitrides, and carbonitrides, termed as MXenes, have been widely applied in energy storage, photocatalysis and biomedicine owing to their unique physicochemical properties of large specific surface area, high electrical conductivity, excellent optical performance, good stability, etc. Moreover, due to their strong light absorption capacity in the first and second near-infrared bio-window, and their ability of being simply functionalized with multiple organic/inorganic materials, MXene biomaterials have shown great potential in the field of catalytic therapy. This review will summarize the common catalytic mechanism of MXene biomaterials and their latest applications in catalytic medicine such as tumor therapy, antibacterial and anti-inflammatory, and present the current challenges and opportunities in clinical translation for future development to promote the advancement of MXene biomaterials in the field of catalytic medicine.

Role of lncRNAs in acute pancreatitis: pathogenesis, diagnosis, and therapy.

Acute pancreatitis (AP) is one of the most common acute abdominal diseases characterized by an injury and inflammatory disorder of the pancreas with complicated pathological mechanisms. Long non-coding RNAs (lncRNAs) have been shown to play an important role in various physiological and pathological processes in humans, and they have emerged as potential biomarkers of diagnosis and therapeutic targets in various diseases. Recently, accumulating evidence has shown significant alterations in the expression of lncRNAs, which are involved in the pathogenesis of AP, such as premature trypsinogen activation, impaired autophagy, inflammatory response, and acinar cell death. Moreover, lncRNAs can be the direct target of AP treatment and show potential as biomarkers for the diagnosis. Thus, in this review, we focus on the role of lncRNAs in the pathogenesis, diagnosis, and therapy of AP and emphasize the future directions to study lncRNAs in AP, providing new insight into understanding the cellular and molecular mechanisms of AP and seeking novel biomarkers for the diagnosis and therapeutic targets to improve clinical management in the future.

Spatial and Temporal Evolution and Prediction of the Coordination Level of "Production-Living-Ecological" Function Coupling in the Yellow River Basin, China.

To clarify the evolution of "production-living-ecological" function coupling in the Yellow River Basin, coordinating the spatial allocation of resources, development management and layout optimization, is an important means for achieving ecological protection and high-quality development in the region. In this paper, we conducted an empirical analysis and ARIMA prediction of the coupled production-living-ecological function coordination level in the Yellow River Basin of China from 2008 to 2018, and found that: (1) In terms of temporal evolution, the production-living-ecological function and coupling coordination level of each province and region in the Yellow River Basin generally shows a sharp and then slow upward trend, with the living functions changing more than the production and ecological functions; (2) in terms of spatial pattern, the production and living functions of each province and region show the trend of functional level increasing from east to west over time; the ecological functions, contrary to production and living functions, show a "high-low" aggregation, midstream shows "low-low" aggregation, and downstream shows "low-high" aggregation; (3) According to the regression results of the spatial Dubin model, the environmental governance level, technological research and development level, and social security level and resource dependence degree have positive promoting and spillover effects on the coupling coordination level of the "production-living-ecological" function in the region. However, population density and carbon emission intensity will hinder the development of regional coupling coordination level; (4) from the ARIMA prediction, the coupling coordination level of "production-living-ecological" in the Yellow River Basin continues the development trend of 2008-2018 in the short term, the overall coordination level is at a high level, and the variability of coupling coordination level among provinces and regions is further reduced. Finally, corresponding development countermeasures and suggestions are given to different provinces and regions based on the spatial and temporal evolution characteristics, influencing factors and development trend of the "production-living-ecological" function in the Yellow River basin.