[Effect of exogenous administration of platelet-derived growth factor and epidermal growth factor on duodenal ulcer healing in rats treated with indomethacin]. / Efecto de la administración exógena de PDGF y EGF en la cicatrización de la úlcera duodenal en ratas tratadas con indometacina.

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) delay peptic ulcer healing through mechanisms that are still not entirely understood. Growth factors play a significant role in healing. AIM: To evaluate whether exogenous administration of platelet-derived growth factor (PDGF) reverses the effect of indomethacin in experimental duodenal ulcers in rats and to define the potential mechanisms involved in this process. METHOD: Duodenal ulcer was induced in male Wistar rats with acetic acid. The rats were then administered indomethacin (2 mg/kg/day), PDGF-BB (30 ng/100 g/day), epidermal growth factor (EGF) (50 /kg/day) or famotidine (positive control) or the possible combinations of these. Macroscopic area, reduction in microscopic diameter, epithelial and granulation tissue proliferation, collagen secretion by granulation tissue, and gastric acid secretion were analyzed. RESULTS: Indomethacin delayed duodenal ulcer healing by decreasing cellular proliferation and inhibiting collagen secretion. PDGF and EGF accelerated healing and reversed the effects of indomethacin. The mechanisms involved were associated with an increase in collagen proliferation and secretion without affecting gastric acid secretion. Famotidine also accelerated healing and reversed the effect of indomethacin, and these effects were associated with a marked inhibition of gastric acid secretion and increase in collagen secretion by granulation tissue. CONCLUSIONS: Exogenous administration of PDGF and EGF accelerated healing and reversed the harmful effects of indomethacin in an experimental model of duodenal ulcer.

Tratamiento del estreñimiento

El estreñimiento es un síntoma más que una enfermedad y representa, por tanto, la interpretación subjetiva de una alteración real o imaginaria de la función intestinal. Aunque el estreñimiento se define por una frecuencia defecatoria de dos veces por semana o menos, la frecuencia por sí sola no es criterio suficiente. Muchos pacientes aquejan únicamente un mayor esfuerzo defecatorio con una frecuencia defecatoria normal. Esta amplia constelación de síntomas contribuye, en parte, a la confusión existente sobre la incidencia, patogénesis y tratamiento del estreñimiento.Interpretar las percepciones del paciente y corregir sus errores conceptuales acerca del hábito defecatorio normal constituyen aspectos críticos del tratamiento inicial (AU)

[Expediency of hospital admission for acute diarrhea syndrome in a short-stay unit]. / Oportunidad de ingreso hospitalario del síndrome de diarrea aguda en una unidad de corta estancia.

We present the results of a 187 cases acute diarrhea study managed in the Short Stay Unit of Clinic Universitary Hospital of Zaragoza during 1987-1988. To that aim, we designed an actuation protocol which included the gathering of several data, the realization of complementary studies and the evolutive pursuit. The coproculture resulted positive in a 54.5% of cases and Salmonella was the microorganism more frequently isolated. Most of the species were sensible to common antibiotics and all of them sensible to norfloxacin. Nearly a third part of patients developed some kind of complication. Therefore we infer that acute diarrhea may be subsidiary of diagnosis and treatment in Short Stay Units.