RESUMO
Four group systems of serum proteins (Hp, Gc, Km, Gm) and five group systems of erythrocyte enzymes (AP, PGM1, GPT, AK, EsD) were determined in samples of patients with rheumatoid arthritis and in healthy controls. Statistically significant differences were found in Gm system, namely Gm(1) factor was more frequent in rheumatoid patients than in healthy subjects.
Assuntos
Artrite Reumatoide/sangue , Proteínas Sanguíneas/metabolismo , Eritrócitos/enzimologia , Fosfatase Ácida/sangue , Adenilato Quinase/sangue , Alanina Transaminase/sangue , Artrite Reumatoide/genética , Proteínas Sanguíneas/genética , Esterases/sangue , Frequência do Gene , Humanos , Alótipos de Imunoglobulina , Fenótipo , Fosfoglucomutase/sangueRESUMO
HLA antigens were typed in 42 asymptomatic carriers of HBs antigen and in 20 carriers of anti-HBs antibodies. An increased frequency of HLA-B8 antigen was detected in the group of HBs antigen carriers (p less than 0.025). For individuals with the antigen the relative risk (RR) of carrying HBs was increased to 2.3 at p (0.53 less than RR less than 1.89) greater than or equal 1-0.001.
Assuntos
Anticorpos Antivirais/análise , Antígenos HLA/análise , Antígenos de Superfície da Hepatite B/análise , Portador Sadio/imunologia , Frequência do Gene , Antígenos HLA/genética , Hepatite Viral Humana/imunologia , Humanos , Fenótipo , RiscoRESUMO
Lymphocytes from 26 patients with primary gout were typed for eighteen antigens from A and B loci. An increased "relative risk" of the disease was established in patients carrying antigen HLA-B14, but the correlation is not sufficient for using HLA typing as a diagnostic tool in the gout. Nevertheless HLA-B14 seems to be one of the genetic factors which predispose to the appearance of the articular lesions.
Assuntos
Gota/imunologia , Antígenos HLA/análise , Adulto , Frequência do Gene , Antígenos HLA/genética , Humanos , Masculino , RiscoRESUMO
One hundred twenty-five patients with rheumatoid arthritis were typed for 21 HLA antigens from A and B loci. The antigen frequencies found in patients were compared with the frequencies in a control population of 300 healthy individuals. No statistically significant differences were observed between patients and the control group.