NRF2 attenuation aggravates detrimental consequences of metabolic stress on cultured porcine parthenote embryos.

The nuclear factor erythroid 2-related factor 2 (NRF2) is a crucial transcription factor that plays a central role in regulating oxidative stress pathways by binding antioxidant response elements, but its involvement in early embryo development remains largely unexplored. In this study, we demonstrated that NRF2 mRNA is expressed in porcine embryos from day 2 to day 7 of development, showing a decrease in abundance from day 2 to day 3, followed by an increase on day 5 and day 7. Comparable levels of NRF2 mRNA were observed between early-cleaving and more developmental competent embryos and late-cleaving and less developmental competent embryos on day 4 and day 5 of culture. Attenuation of NRF2 mRNA significantly decreased development of parthenote embryos to the blastocyst stage. When NRF2-attenuated embryos were cultured in presence of 3.5 mM or 7 mM glucose, development to the blastocyst stage was dramatically decreased in comparison to the control group (15.9% vs. 27.8% for 3.5 mM glucose, and 5.4% vs. 25.3% for 7 mM glucose). Supplementation of melatonin moderately improved the development of NRF2-attenuated embryos cultured in presence of 0.6 mM glucose. These findings highlight the importance of NRF2 in early embryo development, particularly in embryos cultured under metabolically stressful conditions.

Health-related patterns and chronic kidney disease in the Brazilian population: National Health Survey, 2019.

Objective: The aim of this study was to identify patterns related to health and their association with chronic kidney disease (CKD) in the Brazilian population. Methods: We used data from the National Health Survey (PNS), 2019. Participants were interviewed and answered questions related to socioeconomic and demographic information (gender, age, education, race/color), health conditions (presence of hypertension, diabetes mellitus, hyperlipidemia, cardiovascular disease, overweight and CKD) and lifestyle (smoking, alcohol consumption, physical activity and food consumption). To identify patterns, we used exploratory factor analysis. We performed logistic regression models to describe the association of CKD with each pattern in crude models and adjusted for gender, age group, education level and race/color. Results: A total of 90,846 individuals were evaluated. The prevalence of CKD was 1.49% (95% CI: 1.3-1.6). Three health-related patterns - metabolic factors, behavioral risk factors and behavioral protective factors - were identified by factor analysis. Metabolic factors were determined by the presence of hypertension, diabetes mellitus, hyperlipidemia and cardiovascular diseases. Behavioral risk factors were determined by smoking, alcohol consumption, regular consumption of soft drinks, sweets and artificial juices, and high salt consumption. The protective behavioral factors were established by the practice of physical activity and regular consumption of vegetables and fruits. Participants of the highest tertile for metabolic factors were more likely to have CKD in the adjusted model (OR = 3.61, 95% CI: 2.69-4.85), when compared to those of the lower tertile. Conclusion: The pattern referring to metabolic factors was associated with a higher chance of presenting CKD.

Dermatological manifestations of hematologic neoplasms. Part II: nonspecific skin lesions/paraneoplastic diseases

Abstract Cutaneous manifestations occur in the course of hematologic malignancies and precede, accompany or occur late in relation to the diagnosis. They result from paraneoplastic phenomena, tumor infiltrations, immunosuppression resulting from the hematologic disease itself or its treatment. The dermatologist must be aware of these conditions that may be helpful both in the diagnosis of the underlying disease and in reducing patient morbidity. This review (part II) addresses the paraneoplastic dermatological changes associated with systemic hematologic malignancies.

Dermatological manifestations of hematologic neoplasms. Part I: secondary specific skin lesions

Abstract Cutaneous manifestations occur during the course of hematologic malignancies and precede, follow, or are late events in relation to the diagnosis. They result from paraneoplastic phenomena, tumor infiltrations, and immunosuppression resulting from the hematologic neoplasia itself or its treatment. The dermatologist must be aware of these conditions, which can help both in the diagnosis of the underlying disease and in the reduction of patient morbidity. This review (part I) addresses skin lesions associated with direct infiltration by systemic hematologic malignancies.

Dermatological manifestations of hematologic neoplasms. Part II: nonspecific skin lesions/paraneoplastic diseases.

Cutaneous manifestations occur in the course of hematologic malignancies and precede, accompany or occur late in relation to the diagnosis. They result from paraneoplastic phenomena, tumor infiltrations, immunosuppression resulting from the hematologic disease itself or its treatment. The dermatologist must be aware of these conditions that may be helpful both in the diagnosis of the underlying disease and in reducing patient morbidity. This review (part II) addresses the paraneoplastic dermatological changes associated with systemic hematologic malignancies.

Dermatological manifestations of hematologic neoplasms. Part I: secondary specific skin lesions.

Cutaneous manifestations occur during the course of hematologic malignancies and precede, follow, or are late events in relation to the diagnosis. They result from paraneoplastic phenomena, tumor infiltrations, and immunosuppression resulting from the hematologic neoplasia itself or its treatment. The dermatologist must be aware of these conditions, which can help both in the diagnosis of the underlying disease and in the reduction of patient morbidity. This review (part I) addresses skin lesions associated with direct infiltration by systemic hematologic malignancies.

Avaliação psicológica hospitalar: experiência de parametrização de intervenções assistenciais em maternidade-escola de alto risco / Hospital psychological assessment: experience of parameterisation of maternity-high-risk school care interventions / Evaluación psicológica hospitalaria: experiencia de la parametrización de las intervenciones de asistencia en maternidad escolar de alto riesgo

Objetivo: Apresentar a experiência de parametrização de intervenções de avaliação psicológica hospitalar de gestantes e puérperas internadas em situação de alto risco. Relato de experiencia: A atividade foi empreendida em Maternidade-Escola pública de alta complexidade, referência em alto risco, em Teresina, Piauí, de abril a junho de 2023, circunscrita ao Estágio Supervisionado Profissionalizante em Psicologia da Saúde. A partir da imersão no campo para articulação ensino-serviço, com supervisão teórico- prática semanal in loco (presencial) e mediante reuniões síncronas (Google Meet), realizou-se debates sobre as experiências de ensino-aprendizagem e para confecção de uma proposta de roteiro de exame e avaliação psicológica, com o intuito de nortear a atuação dos estagiários, bem como de contribuir com o robustecimento da instrumentalização e orientação das intervenções assistenciais de psicologia na instituição hospitalar. A proposta de instrumento orientador desenvolvido possui doze partes: identificação; motivo da hospitalização; situação de saúde; situação de crise; exame psíquico; sono; sintomas psicossomáticos emergentes; sentido da vida; maternagem e cuidado ao bebê; estratégias de coping; síntese; hipótese diagnóstica. Considerações finais: O roteiro de exame e avaliação psicológica robustece a parametrização de intervenções de psicologia em saúde nos hospitais; vivifica o desenvolvimento e fortalecimento de competências e habilidades para conduzir a avaliação psicológica hospitalar de maneira eficiente, técnica, ética, que dignifique o cuidado perinatal materno sob a égide da integralidade e baseado em evidências.

Objective: To present the experience of parameterisation of hospital psychological evaluation interventions of pregnant women and those who have recently given birth in a high risk situation. Experience report: The activity was undertaken in Maternity-High complexity public school, reference in high risk, in Teresina, Piauí, from April to June 2023, circumscribed to the Supervised Professional Internship in Health Psychology. From immersion in the field for teaching-service articulation, with weekly theoretical-practical supervision in loco (in person) and through synchronous meetings (Google Meet), debates were held on teaching-learning experiences and to prepare a proposal for a roadmap for psychological examination and evaluation, with the aim of guiding the work of trainees, as well as contributing to the strengthening of the instrumentalisation and orientation of psychological assistance interventions in the hospital institution. The proposed guiding instrument developed has twelve parts: identification; reason for hospitalisation; health situation; crisis situation; psychic examination; sleep; emerging psychosomatic symptoms; sense of life; maternity and baby care; coping strategies; synthesis; diagnostic hypothesis. Concluding considerations: The psychological examination and assessment roadmap strengthens the parametrisation of health psychology interventions in hospitals; it vivifies the development and strengthening of competencies and skills to conduct hospital psychological assessment in an efficient, technical, ethical manner, that dignifies maternal perinatal care under the aegis of completeness and evidence-based.

Propósito: Proporcionar la experiencia de parametrización de las intervenciones de evaluación psicológica hospitalaria de las mujeres embarazadas y las personas que adoptan a temprana edad en situaciones de alto riesgo. Informe de la experiencia: La actividad se realizó en la Escuela Maternidad-Pública de alta complejidad, una referencia de alto riesgo en Teresina, Piauí, de abril a junio de 2023, limitada a la Etapa altamente profesional supervisada en Psicología de la Salud. A raíz de la inmersión en el ámbito de la vinculación entre la educación y los servicios, con la supervisión teórico-práctica in loco (asistencia) y mediante reuniones sincrónicas (Google Meet), se celebraron debates sobre las experiencias de enseñanza-aprendizaje y una propuesta de hoja de ruta para el examen y la evaluación psicológicos, con el fin de orientar la labor de los pasantes y contribuir a fortalecer la instrumentalización y orientación de las intervenciones de asistencia psicológica en el hospital. La propuesta de un instrumento de orientación desarrollada consta de doce partes: identificación; motivo de hospitalización; situación de salud; situación de crisis; examen psicológico; sueño; síntomas psicosomáticos emergentes; sentido de la vida; maternidad y cuidado del bebé; estrategias de afrontamiento; síntesis; hipótesis diagnósticas. Consideraciones finales: La hoja de ruta para el examen y la evaluación psicológicos fortalece la parametrización de las intervenciones de psicología sanitaria en los hospitales; ilustra el desarrollo y el fortalecimiento de las aptitudes y capacidades para llevar a cabo una evaluación psicológica hospitalaria de manera eficiente, técnica y ética que dignifica la atención perinatal materna bajo los auspicios de la exhaustividad y basada en pruebas.

Consumption of ultra-processed foods and risk for Alzheimer's disease: a systematic review.

Objective: To investigate the association of the consumption of ultra-processed foods with the risk of developing Alzheimer's disease in adults and the elderly. The review protocol was registered on PROSPERO (CRD42022375944). Methods: This is a systematic review reported according to PRISMA guidelines. Observational studies were included without language or publication year restrictions. Studies assessing only other types of dementia as outcomes, not considering Alzheimer's disease, were excluded. The research was carried out in the Medline, Embase, Lilacs databases, and a survey of the gray literature between April and November 2023, in addition to citation search in the included studies. Data extraction was performed by two independent reviewers. The risk of bias and methodological quality of the included studies were assessed using the Joanna Briggs Institute checklist for cohort studies. Results: A total of 5 studies involving 617,502 adults and elderly people were included. All studies had a cohort design and were considered of high methodological quality. Of the included studies, 4 demonstrated a risk association between the consumption of ultra-processed foods and the development of Alzheimer's disease, while 1 study showed a risk association only with the development of cognitive decline. Discussion: The association between ultra-processed foods consumption and the risk of developing Alzheimer's disease is a recent topic in scientific studies, given that the oldest study identified by our review dates back to 2017. Of the four included studies, three showed a significant association between ultra-processed foods consumption and the risk of developing Alzheimer's disease.

Tramas do racismo e das violências na infância brasileira: a obra de arte "Amnésia" / Plots of racism and violence in Brazilian childhood: the artwork "Amnesia" / Tramas de racismo y violencia en la infancia brasileña: la obra de arte "Amnesia"

Este artigo busca tecer relações sobre a infância, o racismo e as violências a fim de tensionar as linhas que fundamentam discursos e práticas sobre o processo de subjetivação da criança negra no Brasil. Inspiradas em conceitos da Filosofia da Diferença - Esquizoanálise proposta pelos filósofos Deleuze e Guattari, nos estudos étnico-raciais e na obra de arte "Amnésia" de Flávio Cerqueira, apresentaremos alguns fios de análise sobre os diagramas de poder que aprisionam a experiência da infância da criança negra em linhas de sujeição e as resistências que se entreabrem a partir da arte como uma potente intercessora. Consideramos que as capturas do embranquecimento e da miscigenação evocados pela obra indicam que a relação de poder associada ao racismo entranha na sociedade brasileira produzindo subjetividades. Dialogando com Stuart Hall veremos que o racismo será entendido como discurso, pois configura na cultura uma inteligibilidade relativa as diferenças humanas. Importante salientar que apesar da crítica atual realizada por diferentes áreas do conhecimento ao conceito de raça como categoria analítica, ela continua a operar com força através da captura das subjetividades, justamente, por estar pulverizada nas práticas e nos discursos e, sobretudo, em mecanismos estéticos, políticos, ideológicos e morais. Ainda, a partir do bloco de sensações que a arte revoluciona consideramos importante pensar a infância da criança negra como devir-minoritário e tecemos análises sobre a potência que essa obra de arte exala seja apontando para a linha de sujeição do racismo e do embranquecimento, como também, exacerbando a linha de fuga aos moldes violentos que a infância minoritária da criança negra anuncia sobre a existência e os modos de subjetivar.

This article seeks to weave relationships about childhood, racism, and violence in order to stress the lines that underlie the discourses and practices on the process of subjectivation of the Black child in Brazil. Inspired by concepts from the Philosophy of Difference - Schizoanalysis proposed by the philosophers Deleuze and Guattari, in ethnic-racial studies and in the artwork "Amnesia", by Flávio Cerqueira, we will present some threads of analysis on the diagrams of power that imprison the black child´s childhood experience in lines of subjection and the resistances that are half-opened from art as a powerful intercessor. We consider that the captures of whitening and miscegenation evoked by the work indicate that the power relationship associated with racism permeates Brazilian society producing subjectivities. In dialogue with Stuart Hall, we will see that racism will be understood as discourse, as it configures in culture an intelligibility related to human differences. It is important to point out that despite the current criticism made by different areas of knowledge to the concept of race as an analytical category, it continues to operate with force through the capture of subjectivities, precisely because it is pulverized in practices and discourses and, above all, in aesthetic, political, ideological, and moral mechanisms. Still, from the block of sensations that art revolutionizes, we consider it important to think of the black child as a minor-becoming and we will weave analyzes with the power that this work of art exudes, whether pointing to the line of subjection of racism and whitening, as well as, exacerbating the line of flight to the violent molds that the minority childhood of the black child announces about the existence and the ways of subjectivizing.

Este artículo busca tejer relaciones sobre infancia, racismo y violencia para subrayar las líneas que subyacen en los discursos y prácticas sobre el proceso de subjetivación del niño negro en Brasil. Inspirándonos en conceptos de la Filosofía de la Diferencia - Esquizoanálisis propuestos por los filósofos Deleuze y Guattari (1995), en los estudios étnico-raciales y en la obra de arte "Amnesia", de Flávio Cerqueira (2015), presentaremos algunos hilos de análisis sobre los esquemas de poder que aprisionan la experiencia da infancia del niño negro en líneas de sujeción y las resistencias que se entreabren desde el arte como poderoso intercesor. Consideramos que las capturas de blanqueamiento y mestizaje evocadas por la obra indican que la relación de poder asociada al racismo permea la sociedad brasileña produciendo subjetividades. En diálogo con Stuart Hall, veremos que el racismo será entendido como discurso, en tanto configura en la cultura una inteligibilidad relacionada con las diferencias humanas. Es importante señalar que a pesar de las críticas actuales que desde diferentes áreas del conocimiento se hacen al concepto de raza como categoría analítica, ésta sigue operando con fuerza a través de la captura de subjetividades, precisamente porque se encuentra pulverizada en prácticas y discursos y, sobre todo, en los mecanismos estéticos, políticos, ideológicos y morales. Todavía, desde el bloque de sensaciones que revoluciona el arte, consideramos importante pensar al niño negro como un devenir-minoría y tejeremos análisis con la potencia que destila esta obra de arte, ya sea apuntando a la línea de sujeción del racismo y blanquear, así como, exacerbar la línea de fuga a los moldes violentos que la infancia minoritaria del niño negro anuncia sobre la existencia y las formas de subjetivar.

Medicamentos vencidos e/ou armazenados no domicílio de estudantes e o correto descarte: um estudo de caso

Objetivos Quantificar e qualificar por classes terapêuticas os medicamentos vencidos e/ou armazenados no domicílio de estudantes dos cursos técnicos do eixo saúde do Colégio Tecnológico Jerônimo Carlos do Prado, em Goiatuba, GO. Metodologia: A pesquisa foi realizada através de coleta de medicamentos em desuso obtidos da farmácia domiciliar dos estudantes por entrega voluntária e anônima. Resultados: Foram coletados 86 medicamentos, dos quais 77,9% estavam com a validade expirada. O número de medicamentos prescritos sem retenção de receita foi maior em relação aos prescritos com retenção de receita e venda livre. A classe terapêutica mais comum foi o anti-inflamatório não-esteroide, seguido dos analgésicos e os antimicrobianos. Alguns medicamentos apresentaram lascas e alteração de cor dos comprimidos e, no caso das soluções, foram encontradas crostas ao redor da tampa, evidenciando oxidação e alteração do produto. Conclusões: Logo, mesmo entre estudantes da área de saúde ocorre a prática do armazenamento de medicamentos e alguns em condições inadequadas. A aquisição racional de medicamentos deve ser um tema imprescindível a ser trabalhado em todos os níveis de ensino e também nas palestras educativas oferecidas pelas Unidades Básicas de Saúde. A população precisa de educação em saúde para apreender sobre as práticas corretas de armazenamento e descarte de medicamentos.

Objetivo: Cuantificar y clasificar los medicamentos por clases terapéuticas vencidos o almacenados en los domicilios de alumnos de cursos técnicos en el eje de salud del Colegio Tecnológico Jeronimo Carlos do Prado, en Goiatuba, GO. Metodología: La investigación se realizó a través de la recolección de medicamentos en desuso obtenidos de la farmacia domiciliaria de los estudiantes por entrega voluntaria y anónima. Resultados: Se recogieron 86 medicamentos, de los cuales el 77,9% estaban vencidos. El número de medicamentos de prescripción sin retención de prescripción fue mayor en relación a los prescritos con retención de prescripción y venta sin receta. La clase terapéutica más común fue el antiinflamatorio no esteroideo, seguido de los analgésicos y los antimicrobianos. Algunas drogas mostraron astillas y cambio de color en los comprimidos y, en el caso de las soluciones, costras alrededor de la tapa, evidenciando oxidación y alteración del producto. Conclusiones: Incluso entre estudiantes del área de la salud, se da la práctica de almacenar medicamentos y algunos en condiciones inadecuadas. La adquisición racional de medicamentos debe ser un tema fundamental a trabajar en todos los niveles educativos y también en las charlas educativas ofrecidas por las Unidades Básicas de Salud. La población necesita educación sanitaria para conocer las prácticas correctas de almacenamiento y disposición de medicamentos.

SUMMARY Aim: To quantify and classify the medicines by therapeutic classes expired or stored in the homes of students of technical courses in the health eje del Colegio Tecnológico Jeronimo Carlos do Prado, in Goiatuba, GO. Methodology: The investigation was carried out through the collection of disused medicines obtained from the home pharmacy of students by voluntary and anonymous delivery. Results: 86 medications were recovered, of which 77.9% were expired. The number of prescription drugs without prescription retention was greater in relation to prescriptions with prescription retention and sale without prescription. The most common therapeutic class was the anti-inflammatory drug on the steroid, followed by analgesics and antimicrobials. Some drugs showed astills and color change in pills and, in the case of solutions, around the tapa, evidencing oxidation and alteration of the product. Conclusions: Even among students from the health area, there is a practice of storing medicines and some in inadequate conditions. The rational acquisition of medicines should be a fundamental issue to work at all educational levels and also in the educational talks offered by the Basic Health Units. The population needs health education to know the correct practices of storage and disposal of medicines.

Fatores associados ao conhecimento da dengue no município de Parauapebas, Pará / Factors associated with knowledge of dengue in the municipality of Parauapebas, Pará

A dengue é uma das arboviroses de maior incidência no Brasil e no mundo. Compreender como ela se associa a diversos fatores é de suma importância para tentar diminuir sua incidência. Dessa forma, este estudo foi realizado no ano de 2018 em bairros, tanto da zona urbana quanto da zona rural, do município de Parauapebas, no estado do Pará, com o objetivo de gerar um modelo probabilístico para descrever a probabilidade de uma pessoa do município de Parauapebas conhecer como os patógenos da doença podem ser transmitidos e sobre os sintomas da doença. Foram utilizadas técnicas estatísticas de análise exploratória de dados para descrever as variáveis utilizadas no modelo e a regressão logística múltipla, onde, de acordo com os dados obtidos, na cidade de Parauapebas, que as mulheres têm mais de duas vezes mais chance de saber os principais sintomas da doença do que uma pessoa do sexo masculino. Constatou-se ainda que uma grande parcela da população de Parauapebas não sabe como é a forma de transmissão da dengue.

Dengue is one of the arboviruses with the highest incidence in Brazil and worldwide. Understanding how it is associated with several factors is of paramount importance in trying to reduce its incidence. Thus, this study was carried out in 2018 in neighborhoods, both in the urban and rural areas of the municipality of Parauapebas in the state of Pará, with the aim of generating a probabilistic model to identify an identification of a person in the municipality from Parauapebas knows how the pathogens of the disease can be transmitted the form of dengue transmission and about the symptoms of the disease. Statistical statistics of exploratory data analysis were used to describe the variables used in the model and multiple logistic regression, where according to the data obtained, in the city of Parauapebas, women are more than twice as likely to know the major symptoms of the disease than a male person. It was also found that a person who a large portion of the population of Parauapebas does not know how the form of transmission of dengue is.

Hemostasis and oxidative stress in chronic kidney disease in children and adolescents.

Chronic kidney disease (CKD) can be defined as the progressive loss of renal function, characterized by a decreased glomerular filtration rate (GFR). The etiology of CKD in childhood is mainly associated with congenital anomalies of the kidneys and urinary tract (CAKUT) and with glomerular diseases. The goal of this study was to investigate the hemostasis and oxidative stress in pediatric CKD of different etiologies. Fifty-four CKD children and adolescents and 52 controls were enrolled in this study. The evaluation of hemostasis was carried out by determination of D-dimer (D-Di) and plasminogen activator inhibitor (PAI-1) plasma levels, while oxidative stress was evaluated by thiobarbituric acid reactive substance (TBARS) levels, protein carbonyl content, plasma antioxidant capacity (MTT), and ascorbate. The D-Di was increased in CAKUT stage 3 or 4 patients compared with those with glomerular disease. PAI-1 was increased in patients with glomerular disease compared with CAKUT. Carbonyl protein content was higher in the control group compared with glomerular disease stage 3 or 4 patients. Our findings showed that the reduction in GFR is associated with a state of hypercoagulability. The analysis of integrated networks showed an expansion of connections among hemostatic and oxidative stress markers in CKD children and adolescents compared with controls.

Nutritional influences on biomass behaviour and metabolic products by Chlamydomonas reinhardtii.

The recent works have shown the unicellular green alga Chlamydomonas reinhardtii is a relevant model for investigations of algal bioprocesses. In the current work, several media were evaluated in batch mode for a better understanding of C. reinhardtii metabolism. Nutrient-suppression using heterotrophic and mixotrophic conditions were performed. The findings showed C. reinhardtii metabolized lactose (from milk whey permeate) resulting in high biomass density (2.08 g/L) and total chlorophyll content (86.74 mg/m3). It was observed a specific growth rate of 0.023 h and 29 h for the doubling time. In sulfur-suppression, the algal growth (1.17 g/L) was reduced even though a carbon source (glucose) has been supplemented. Also, the specific growth rate (0.022 h) and the doubling time (31 h) was verified. The production of ethanol was slight and the acetic acid-suppression affected the C. reinhardtii performance providing slow cell growth (0.004 h) and high doubling time (154 h).

Exposição íntima online: experiências de mulheres brasileiras e seu acesso a políticas públicas / Online intimate exposure: experiences of brazilian women and their access to public policies / Exposición íntima online: experiencias de mujeres brasileñas y su acceso a las políticas públicas

Exposição íntima online (conhecida como pornografia de vingança; slut shaming) consiste na divulgação, ou ameaça, de materiais íntimos da vítima, caracterizando uma cultura, atualizada através da internet, de exposição e humilhação de mulheres por sua sexualidade. Este artigo se propõe a analisar as experiências de exposição íntima online vivenciadas pelas mulheres brasileiras usuárias da internet e as políticas públicas por elas acessadas. A pesquisa, qualitativa e fundamentada na perspectiva de gênero foi realizada através de questionário online respondido por 1.028 mulheres. Os dados foram analisados através de estatística descritiva e análise de conteúdo temático-categorial, com auxílio dos softwares SPSS e MaxQDA. Cinco por cento das participantes haviam sofrido exposição íntima online, praticada majoritariamente por um parceiro ou ex-parceiro. A busca por políticas públicas foi baixa e identificada como insatisfatória. Estimamos que os resultados possam contribuir com a construção do conhecimento científico e embasar o atendimento profissional às vítimas de exposição íntima online.

Online intimate exposure (known as revenge porn; slut shaming) consists in the disclosure, or threat, of the victim's intimate material, characterizing a culture, updated through the internet, of exposure and humiliation of women for their sexuality. This article aims to analyze the experiences of online intimate exposure experienced by Brazilian women who use the internet and the public policies accessed by them. The research, being qualitative and based on a gender perspective, was conducted through an online questionnaire, answered by 1.028 women. The data was analyzed using descriptive statistics and thematic-categorical content analysis, with the aid of the softwares SPSS and MaxQDA. Five percent of the participants had undergone intimate online exposure, mostly practiced by a partner or ex-partner. The search for public policies was low and identified as unsatisfactory. We estimate that the results can contribute to the construction of scientific knowledge and support professional care for victims of online intimate exposure.

La exposición íntima online (conocida como pornografía de venganza; slut shaming) consiste en la divulgación, o amenaza, del material íntimo de la víctima, caracterizando una cultura, actualizada a través de Internet, de humillación de mujeres por su sexualidad. Este artículo pretende analizar las experiencias de exposición íntima online vividas por mujeres brasileñas que utilizan internet y las políticas públicas a las que acceden. La investigación, cualitativa y en base a una perspectiva de género, fue realizada a través de un cuestionario online, respondido por 1.028 mujeres. Los datos se analizaron mediante estadística descriptiva y el análisis de contenido temáticocategórico, con la ayuda de los programas SPSS y MaxQDA. Cinco por ciento de las participantes habían sufrido exposición íntima online, en su mayoría practicada por una pareja o expareja. La búsqueda de políticas públicas fue baja y identificada como insatisfactoria. Estimamos que los resultados pueden contribuir a la construcción de conocimiento científico y apoyar la atención profesional a las víctimas de exposición íntima online.

Significados e representações do uso recreativo de maconha para mulheres / Meanings and representations of recreational use of marijuana by women

Diante das especificidades de gênero, este trabalho busca identificar o significado do uso recreativo de maconha para as mulheres em momentos de lazer. O estudo é uma pesquisa social desenvolvida por meio de entrevistas semiestruturadas. Foram entrevistadas 8 mulheres, acessadas pelo método 'Bola de Neve'. Resultados: Foram definidas as seguintes categorias de sentidos atribuídos ao uso da maconha pelas mulheres: sociabilidade, relacionamentos afetivos e sexo com uso da maconha; relaxamento e descanso; 'calmante' e medicamento; autoconhecimento, afirmação de identidade e criatividade. De acordo com os achados da pesquisa foi identificado que a maconha se insere no universo feminino como parte constituinte da cultura e da identidade das mulheres usuárias.

In view of gender specificities, this paper discusses the meaning of recreational use of marijuana by women at leisure. The study was a social survey was conducted through semi-structured interviews. Eight women were interviewed, they were accessed using the Snowball sampling method. Results: the data were systematized into categories of meanings attributed to the use of marijuana by women: sociability, affective relationships and sex with marijuana use; relaxation and rest; 'Soothing' and medicine; self-knowledge, identity affirmation and creativity. According to research findings, it was identified that marijuana is inserted in the female universe as a constituent part of the culture and identity of women.

Behavioral assessment tests for central hearing skills in individuals with sensorineural hearing loss: an integrative review / Testes para a avaliação comportamental das habilidades auditivas centrais em indivíduos com perdas auditivas neurossensorial: uma revisão integrativa

ABSTRACT Purpose: to identify the most used tests and the changed hearing skills in the central auditory processing of individuals with sensorineural hearing loss. Methods: an integrative literature review conducted between March and August 2021 in PubMed/MEDLINE, LILACS, SciELO, IBECS, and Index Psi Scientific Journals. The review included studies addressing central hearing skills with central auditory processing behavioral tests in subjects with mild to moderate sensorineural hearing loss. Two independent reviewers made the study selection, data extraction, and qualitative synthesis. The selection aimed at verifying whether the studies answered the research question. Literature Review: 39 studies were found for full-text reading; after applying the eligibility criteria, 13 studies were included in the review. Participants diagnosed with sensorineural hearing loss predominantly had hearing changes in verbal tests, in comparison with normal standards for individuals without hearing loss. Thus, the most changed skills are the ones that depend on speech sound discrimination. Conclusion: the Staggered Spondaic Word Test predominated among the most used behavioral tests, while the most researched central auditory skills were binaural integration and binaural separation.

RESUMO Objetivo: identificar os testes mais utilizados e as habilidades auditivas alteradas no processamento auditivo central, em indivíduos com perda auditiva neurossensorial. Métodos: revisão de literatura integrativa, realizada de março a agosto de 2021 nas bases de dados: PubMed/Medline, Lilacs, Scielo, IBECS e Index Psicologia Periódicos técnico-científicos. Foram incluídos estudos que realizaram a pesquisa das habilidades auditivas centrais, através do teste comportamental do processamento auditivo central, em sujeitos portadores de perda auditiva neurossensorial, de grau leve a moderado. A seleção, extração e síntese qualitativa foram realizadas por dois revisores independentes. A seleção teve como objetivo verificar se os estudos contemplavam a pergunta do estudo. Revisão da Literatura: foram encontrados 39 estudos para leitura do texto na íntegra e, ao aplicar os critérios de elegibilidade, foram incluídos 13 estudos. Observou-se que os participantes diagnosticados com perda auditiva neurossensorial apresentam predomínio de alteração auditiva em testes verbais quando comparados aos padrões de normalidade estabelecidos para indivíduos sem perda. Sendo assim, as habilidades mais alteradas são as que dependem da discriminação dos sons da fala. Conclusão: entre os testes comportamentais mais utilizados, predominou o teste SSW. Quanto as habilidades auditivas centrais mais pesquisadas foram integração binaural e separação binaural.

Um documentário me disse: a vida como obra de arte das crianças de uma comunidade / A documentary told me: life as a work of art for children in a community / Un documental me dijo: la vida como una obra de arte para niños en una comunidad

Esta pesquisa analisa um documentário chamado Os Caminhos Desconhecidos do Mundo Luz e busca apresentar compreensões sobre o lugar das infâncias numa comunidade em situação de vulnerabilidade social da Região da Grande Florianópolis, identificando cenas que mostram a arte como produção estética da existência. Partindo da análise das práticas discursivas (Spink, 2013), tecemos análises sobre a infância como obra de arte, considerando a arte um recurso estético de afirmação da vida, sobretudo entendendo que as fronteiras estabelecidas entre a cidade e comunidade evidenciam os efeitos das violências. Como resultados, compreende-se a violência como estrutural e estruturante da nossa sociedade e que é feita nos dispositivos da biopolítica e necropolítica. Além disso, as crianças vistas na alegoria da pipa reivindicam uma vida que quer se expandir por outros espaços, colocando para a Psicologia a necessidade de ampliação dos modos de encontro e intervenção com elas nas comunidades do nosso País.

This study analyzes a documentary called The Unknown Paths of the World Light and seeks to present understandings about the place of childhood in a socially vulnerable community in the Greater Florianópolis Region, in Brazil, identifying scenes that show art as an aesthetic production of existence. Based on the analysis of discursive practices (Spink, 2013). The article analyzes childhood as a work of art and the art as an aesthetic resource for affirming life. Mainly, it is understood that the boundaries established between the city and the community show the effects of violence. As a result, violence is understood as structural and structuring of Brazilian society, what is done through the devices of biopolitics and necropolitics. In addition, the children seen in the allegory of the kite, claim a life that wants to expand itself into other spaces, putting to the Psychology the need to expand the ways of meeting and intervention with them in the communities of Brazil.

Esta investigación analiza un documental llamado Los Caminos Desconocidos del Mundo Luz y busca presentar comprensiones sobre el lugar de la infancia en una comunidad en situación de vulnerabilidad social en la Región de Florianópolis, en Brasil, identificando escenas que muestran el arte como una producción estética de la existencia. Partiendo del análisis de las prácticas Discursivas (Spink, 2013), se realizaron análisis sobre la infancia como una obra de arte, considerando el arte un recurso estético de afirmación de la vida, entendiendo, sobre todo, que las fronteras establecidas entre la ciudad y la comunidad demuestran los efectos de la violencia. Como resultado, la violencia se entiende como estructural y estructurante de nuestra sociedad y que se lleva a cabo en los dispositivos de la biopolítica y la necropolítica. Además, los niños vistos en la alegoría de la cometa reclaman una vida que quiere expandirse a otros espacios, planteándole a la Psicología la necesidad de ampliar las formas de encuentro e intervención con ellos en las comunidades de nuestro país.

Where do leaf water leaks come from? Trade-offs underlying the variability in minimum conductance across tropical savanna species with contrasting growth strategies.

Plants continue to lose water from their leaves even after complete stomatal closure. Although this minimum conductance (gleaf-res ) has substantial impacts on strategies of water use and conservation, little is known about the potential drivers underlying the variability of this trait across species. We thus untangled the relative contribution of water leaks from the cuticle and stomata in order to investigate how the variability in leaf morphological and anatomical traits is related to the variation in gleaf-res and carbon assimilation capacity across 30 diverse species from the Brazilian Cerrado. In addition to cuticle permeance, water leaks from stomata had a significant impact on gleaf-res . The differential pattern of stomata distribution in the epidermis was a key factor driving this variation, suggesting the existence of a trade-off between carbon assimilation and water loss through gleaf-res . For instance, higher gleaf-res , observed in fast-growing species, was associated with the investment in small and numerous stomata, which allowed higher carbon assimilation rates but also increased water leaks, with negative impacts on leaf survival under drought. Variation in cuticle structural properties was not linked to gleaf-res . Our results therefore suggest the existence of a trade-off between carbon assimilation efficiency and dehydration tolerance at foliar level.

Preparing Distributed Computing Operations for the HL-LHC Era With Operational Intelligence.

As a joint effort from various communities involved in the Worldwide LHC Computing Grid, the Operational Intelligence project aims at increasing the level of automation in computing operations and reducing human interventions. The distributed computing systems currently deployed by the LHC experiments have proven to be mature and capable of meeting the experimental goals, by allowing timely delivery of scientific results. However, a substantial number of interventions from software developers, shifters, and operational teams is needed to efficiently manage such heterogenous infrastructures. Under the scope of the Operational Intelligence project, experts from several areas have gathered to propose and work on "smart" solutions. Machine learning, data mining, log analysis, and anomaly detection are only some of the tools we have evaluated for our use cases. In this community study contribution, we report on the development of a suite of operational intelligence services to cover various use cases: workload management, data management, and site operations.

Water contamination with atrazine: is nitric oxide able to improve Pistia stratiotes phytoremediation capacity?

Atrazine is an herbicide commonly used in several countries. Due to its long half-life, associated with its use in large scales, atrazine residues remain as environmental pollutants in water bodies. Phytoremediation is often pointed out as an interesting approach to remove atrazine from the aquatic environment, but its practical application is limited by the high toxicity of this herbicide. Here, we characterize the damages triggered by atrazine in Pistia stratiotes, evaluating the role of nitric oxide (NO), a cell-signaling molecule, in increasing the tolerance to the pollutant and the phytoremediation potential of this species. Pistia stratiotes plants were exposed to four treatments: Control; Sodium nitroprusside (SNP) (0.05 mg L-1); Atrazine (ATZ) (150 µg L-1) and ATZ + SNP. The plants remained under those conditions for 24 h for biochemical and physiological analysis and 3 days for the evaluation of relative growth rate. The presence of atrazine in plant cells triggered a series of biochemical and physiological damages, such as the increase in the generation of reactive oxygen species, damages to cell membranes, photosynthesis impairment, and negative carbon balance. Despite this, the plants maintained greater growth rates than other aquatic macrophytes exposed to atrazine and showed high bioconcentration and translocation factors. The addition of SNP, a NO donor, decreased the herbicide toxicity, with an increase of over 60% in the IC50 value (Inhibitor Concentration). Indeed, the NO signaling action was able to increase the tolerance of plants to atrazine, which resulted in increments in pollutant uptake and translocation, with the maintenance of overall cell (e.g. membranes) and organs (root system) structure, and the functioning of central physiological processes (e.g. photosynthesis). These factors allowed for more quickly and efficient removal of the pollutant from the environment, reducing costs, and increasing the viability of the phytoremediation process.