A tentative list of reptilian fauna of Algeria and their conservation status.

Background: Algeria is situated at the crossroads between Europe and Africa. The northern part of the country is listed as an area of high biodiversity. Currently, the ecosystems (rivers, lakes, deserts, forests etc.) and the species are under more pressure than ever. The impact of humans is significant and many factors constitute a strong threat to this fauna, especially reptiles, which are the most vulnerable because of their low mobility. Thus, pollution, the drying up of wetlands and their conversion to agriculture have clearly affected the existence of many species. The herpetofauna of Algeria is one of the most diversified in the Mediterranean Basin, consisting of 104 species of which 16.98% are endemic. We suppose that the present list of reptilian fauna provided in this paper is not exhaustive and it is expected to include more species given the lack of research on reptiles in Algeria and its large area. New information: Our dataset contains information on reptile occurrences in Algeria. The dataset is based on original research by the staff of the Laboratory of Environmental Sciences and Agroecology of Chadli Bendjedid University in Algeria. The conservation status of all recorded species is given.

Oral Glucose Tolerance Test as a Risk Marker for Developing Post-Transplant Diabetes Mellitus.

INTRODUCTION: The incidence of post-transplant diabetes mellitus (PTDM) can reach 30% during the first 6 months after kidney transplantation (KT), increasing the risk of graft failure and mortality. There is no well-established biomarker for predicting PTDM occurrence. This study evaluated the association between the abnormal 2-hour oral glucose tolerance test (OGTT) and the PTDM incidence. METHODS: A retrospective single-center study, including adult kidney transplant recipients from deceased donors, was performed between March 2021 and June 2022. EXCLUSION CRITERIA: age <18 years; pretransplant diabetes mellitus (DM); death with a functioning graft; loss of follow-up and/or graft failure before 6 months post-transplant. The results of pretransplant OGTT, fasting (FPG), and afternoon plasma glucose levels at hospitalization and FPG in the first, second, and third months post-transplant were evaluated. For analysis, patients were grouped according to the PTDM diagnosis: PTDM and non-PTDM. RESULTS: From 164 KT performed in the period, 50 (30%) were included, most male (n = 34, 68%), with a mean age of 48.3 ± 12.5 years. Nine patients (18%) developed PTDM, 44% between 3 and 6 months. General characteristics and immunosuppressive therapy were similar between the groups. The mean FPG in the pretransplant OGTT was significantly higher in the PTDM group compared with the non-PTDM group (85.7 ± 7.9 vs 79.1 ± 8.2, P = .03). The number of patients classified as impaired glucose tolerance (IGT) on the pre-transplant OGTT was significantly higher in the PTDM group. CONCLUSION: IGT in the pretransplant OGTT was associated with PTDM cases in kidney transplant recipients without a previous diagnosis of DM.

Post-Transplant Glomerulonephritis: Challenges and Solutions.

Glomeruli can be damaged in several conditions after kidney transplantation, with a potential impact on the graft function and survival. Primary glomerulonephritis, a group of glomerular immunological damage that results in variable histological patterns and clinical phenotypes, can occur in kidney transplant recipients as a recurrent or de novo condition. Specific immunologic conditions associated with kidney transplantation, such as acute rejection episodes, can act as an additional trigger after transplantation, impacting the incidence of these glomerulopathies. The post-transplant GN recurrence ranges from 3% to 15%, varying according to the GN subtype and post-transplant time, mainly occurring after 3-5 years of kidney transplantation. Advances in the knowledge of glomerulonephritis pathophysiology have provided new approaches to pre-transplant risk evaluation and post-transplant monitoring. Glomeruli can be affected by several systemic viral infections, such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), cytomegalovirus (CMV), and BK virus. The diagnosis of these infections, as well as the identification of possible complications associated with them, are important to minimize the negative impacts of these conditions on kidney transplant recipients' outcomes.

Post-transplant diabetes mellitus: risk factors and outcomes in a 5-year follow-up.

Introduction: Kidney transplantation is associated with an increased risk of posttransplant diabetes mellitus (PTDM), impacting recipient and graft survivals. The incidence of PTDM ranges from 15% to 30%, with most cases occurring in the first year post-transplant. Some clinical and laboratory characteristics pre- and post-transplant may be associated with a higher PTDM incidence in a more extended follow-up period. This study aimed to analyze the prevalence of PTDM among renal transplant recipients without previous DM diagnosis during a five-year post-transplant follow-up, as well as clinical and laboratory characteristics associated with a higher incidence of PTDM during this period. Material and methods: Single-center retrospective cohort including kidney transplant recipients older than 18 years with a functioning graft over six months of follow-up between January and December 2018. Exclusion criteria were recipients younger than 18 years at kidney transplantation, previous diabetes mellitus diagnosis, and death with a functioning graft or graft failure within six months post-transplant. Results: From 117 kidney transplants performed during the period, 71 (60.7%) fulfilled the inclusion criteria, 18 (25.3%) had PTDM diagnosis, and most (n=16, 88.9%) during the 1st year post-transplant. The need for insulin therapy during the hospital stay was significantly higher in the PTDM group (n=11, 61.1% vs. n=14, 26.4%, PTDM vs. non-PTDM). Other PTDM risk factors, such as older age, high body mass index, HLA mismatches, and cytomegalovirus or hepatitis C virus infections, were not associated with PTDM occurrence in this series. During 5-year post-transplant follow-up, the graft function remained stable in both groups. Conclusion: The accumulated incidence of PTDM in this series was similar to the reported in other studies. The perioperative hyperglycemia with the need for treatment with insulin before hospital discharge was associated with PTDM.

Recurrence of membranous nephropathy after kidney transplantation: A multicenter retrospective cohort study.

Membranous nephropathy (MN) is a leading cause of kidney failure worldwide and frequently recurs after transplant. Available data originated from small retrospective cohort studies or registry analyses; therefore, uncertainties remain on risk factors for MN recurrence and response to therapy. Within the Post-Transplant Glomerular Disease Consortium, we conducted a retrospective multicenter cohort study examining the MN recurrence rate, risk factors, and response to treatment. This study screened 22,921 patients across 3 continents and included 194 patients who underwent a kidney transplant due to biopsy-proven MN. The cumulative incidence of MN recurrence was 31% at 10 years posttransplant. Patients with a faster progression toward end-stage kidney disease were at higher risk of developing recurrent MN (hazard ratio [HR], 0.55 per decade; 95% confidence interval [CI], 0.35-0.88). Moreover, elevated pretransplant levels of anti-phospholipase A2 receptor (PLA2R) antibodies were strongly associated with recurrence (HR, 18.58; 95% CI, 5.37-64.27). Patients receiving rituximab for MN recurrence had a higher likelihood of achieving remission than patients receiving renin-angiotensin-aldosterone system inhibition alone. In sum, MN recurs in one-third of patients posttransplant, and measurement of serum anti-PLA2R antibody levels shortly before transplant could aid in risk-stratifying patients for MN recurrence. Moreover, patients receiving rituximab had a higher rate of treatment response.

Factors influencing the work of researchers in Scientific Initiation: A systematic review protocol.

INTRODUCTION: Scientific Initiation (SI) is an educational activity that allows students to begin their scientific training and research under the guidance of an experienced researcher. While several studies have examined students' perceptions of SI, research on the perspective of researchers working in this field is currently lacking. Thus, this study's aim is to describe the protocol design for conducting a systematic review. At the same time, the review aims also to identify factors influencing the work of researchers in SI and explore the motivations leading researchers to engage in research projects within institutions and their respective impacts. METHOD AND ANALYSES: Literature search will be done using the bibliographic databases, including Academic Search Premier, APA PsycNet, CINAHL Plus, ERIC, SocINDEX, Scopus, and Web of Science. The search strategy was guided by the PICo framework (Population, phenomenon of Interest, and Context). The preparation and development of this protocol following guidelines were employed: Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015), Peer Review of Electronic Search Strategies 2015 (PRESS 2015), and PRISMA-Search (PRISMA-S). Original, peer-reviewed articles that examine the factors related to the work of researchers in SI will be included without any language or publication date restrictions. Qualitative, quantitative, and mixed-methods studies will be screened by two independent researchers. The included studies will be analyzed to identify factors, policies, and their impacts obtained analytically. Findings will be objectively categorized and synthetically represented through figures, diagrams, and graphic models. The risk of bias will be assessed using the Critical Appraisal Skills Program (CASP) and the Downs and Black checklists. A third senior reviewer will resolve any discrepancies. DISCUSSION: We aim to understand the factors that drive researchers to engage in SI research through the dissemination of the findings of this systematic review. This may aid the development of institutional strategies and actions that can support the enhancement of SI programs and encourage greater researcher participation.

Brazilian Amazon Red Propolis: Leishmanicidal Activity and Chemical Composition of a New Variety of Red Propolis.

Leishmaniasis is caused by protozoans of the genus Leishmania, and its treatment is highly toxic, leading to treatment discontinuation and the emergence of resistant strains. In this study, we assessed the leishmanicidal activity and chemical composition of red propolis collected from the Amazon-dominated region of northern Tocantins State, Brazil. The MTT assay was employed to determine the samples' activity against Leishmania amazonensis promastigotes and their cytotoxicity against RAW macrophages. Spectrophotometric assays were utilised to measure the concentrations of total phenolics and flavonoids, while high-performance liquid chromatography coupled to a mass spectrometer (LC-MS/MS) was used to determine the chemical composition. An in silico study was conducted to evaluate which compounds from Brazilian Amazon red propolis may correlate with this biological activity. Brazilian Amazon red propolis exhibited a high concentration of phenolic compounds and an inhibitory activity against L. amazonensis, with an IC50 ranging from 23.37 to 36.10 µg/mL. Moreover, fractionation of the propolis yielded a fraction with enhanced bioactivity (16.11 µg/mL). Interestingly, neither the propolis nor its most active fraction showed cytotoxicity towards macrophages at concentrations up to 200 µg/mL. The red colour and the presence of isoflavonoid components (isoflavones, isoflavans, and pterocarpans) confirm that the substance is Brazilian red propolis. However, the absence of polyprenylated benzophenones suggests that this is a new variety of Brazilian red propolis. The in silico study performed with two of the main leishmanicidal drug targets using all compounds identified in Amazon red propolis reported that liquiritigenin was the compound that exhibited the best electronic interaction parameters, which was confirmed in an assay with promastigotes using a standard. The findings indicate that Amazon red propolis possesses leishmanicidal activity, low toxicity, and significant biotechnological potential.

Risk factors for death and illness severity in vaccinated versus unvaccinated COVID-2019 inpatients: a retrospective cohort study.

OBJECTIVE: To determine the clinical profile of COVID-19 inpatients who were vaccinated prior to hospitalization and to compare the risk factors for death and the 28-day survival rate of between those inpatients vaccinated with one, two, or three doses and unvaccinated COVID-19 inpatients. METHODS: This was a retrospective observational cohort study involving COVID-19 patients admitted to a referral hospital in the city of Recife, Brazil, between July of 2020 and June of 2022. RESULTS: The sample comprised 1,921 inpatients, 996 of whom (50.8%) were vaccinated prior to hospitalization. After adjusting the mortality risk for vaccinated patients, those undergoing invasive mechanical ventilation (IMV) had the highest mortality risk (adjusted OR [aOR] = 7.4; 95% CI, 3.8-14.1; p < 0.001), followed by patients > 80 years of age (aOR = 7.3; 95% CI, 3.4-15.4; p < 0.001), and those needing vasopressors (aOR = 5.6; 95% CI, 2.9-10.9; p < 0.001). After adjusting the mortality risk for all patients, having received three vaccine doses (aOR = 0.06; 95% CI, 0.03-0.11; p < 0.001) was the most important protective factor against death. There were progressive benefits of vaccination, reducing the frequency of ICU admissions, use for IMV, and death (respectively, from 44.9%, 39.0% and 39.9% after the first dose to 16.7%, 6.2% and 4.4% after the third dose), as well as significant improvements in survival after each subsequent dose (p < 0.001). CONCLUSIONS: Vaccines were effective in reducing illness severity and death in this cohort of COVID-19 inpatients, and the administration of additional doses conferred them with accumulative vaccine protection.

IgA nephropathy and kidney transplantation according to the Oxford classification / Nefropatia por IgA e transplante renal segundo a classificação de Oxford

Abstract Introduction: IgA nephropathy (IgAN) is the most common glomerular disease globally, and its susceptibility and the risk for the development of end-stage kidney disease are related to genetic and environmental factors. IgAN recurrence after kidney transplantation is relatively common, impacting graft function and survival. This study evaluated the risk factors and the clinical, laboratory, and histological characteristics of post-transplant IgAN recurrence based on the Oxford classification. Material and methods: Retrospective single-center cohort study including kidney transplant recipients with biopsy-proven pre-transplantation IgAN, with analysis of risk factors and clinical, laboratory, and histological characteristics of the IgAN recurrence cases. Results: 53 patients fulfilled the inclusion criteria and were included in the study. The majority was male, white, eutrophic, with a mean age of 27 ± 9 years at IgAN diagnosis. Systemic arterial hypertension and proteinuria were frequent in the pretransplant period. Four recipients (7.5%) presented IgAN recurrence in a period of 6 to 122 months post-transplant. According to the Oxford classification, they had high scores of mesangial hypercellularity and segmental glomerulosclerosis in the native kidney biopsies and there was mesangial hypercellularity in all analyzed graft biopsies. None of these patients had received induction immunosuppression and all of them presented graft failure in the follow-up. Conclusions: In this series, there was a high prevalence of mesangial hypercellularity and segmental glomerulosclerosis on native kidney biopsies, and mesangial hypercellularity occurred in all IgAN recurrence graft biopsies. Despite the lower incidence of recurrence of IgAN post-transplant compared to previous reports, progression to graft loss was of 100%.

Resumo Introdução: Nefropatia por IgA (NIgA) é a doença glomerular mais comum mundialmente. Sua suscetibilidade e risco para desenvolvimento de doença renal em fase terminal estão relacionados a fatores genéticos e ambientais. A recidiva de NIgA pós-transplante é relativamente comum, impactando na função e sobrevida do enxerto. Este estudo avaliou fatores de risco e características clínicas, laboratoriais e histológicas da recidiva de NIgA pós-transplante, com base na classificação de Oxford. Material e métodos: Estudo de coorte retrospectivo de centro único, incluindo receptores de transplante renal com NIgA pré-transplante comprovada por biópsia, com análise dos fatores de risco e características clínicas, laboratoriais e histológicas dos casos de recidiva de NIgA. Resultados: 53 pacientes preencheram critérios de inclusão e foram incluídos no estudo. A maioria era homem, branco, eutrófico, com idade média de 27 ± 9 anos no diagnóstico de NIgA. Hipertensão arterial sistêmica e proteinúria foram frequentes no período pré-transplante. Quatro receptores (7,5%) apresentaram recidiva de NIgA entre 6-122 meses pós-transplante. Segundo a classificação de Oxford, eles apresentaram altos escores de hipercelularidade mesangial e glomeruloesclerose segmentar nas biópsias de rins nativos. Houve hipercelularidade mesangial em todas as biópsias de enxerto analisadas. Nenhum destes pacientes recebeu imunossupressão de indução. Todos apresentaram falência do enxerto no acompanhamento. Conclusões: Nesta série, houve alta prevalência de hipercelularidade mesangial e glomeruloesclerose segmentar em biópsias de rins nativos, e hipercelularidade mesangial ocorreu em todas as biópsias do enxerto de recidiva da NIgA. Apesar da menor incidência de recidiva de NIgA pós-transplante comparada a relatos anteriores, a progressão para perda do enxerto foi de 100%.

Recurrent Membranoproliferative Glomerulonephritis After Kidney Transplantation: Risk Factors and Impact on Graft Survival.

BACKGROUND Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of end-stage renal disease (ESRD). Recurrence rates after transplantation range from 11.8% to 18.9% after 5 and 15 years, respectively. This study aimed to assess the risk factors of MPGN recurrence after kidney transplantation and its impact on graft survival. MATERIAL AND METHODS This was a single-center retrospective cohort, including renal transplant recipients older than 18 years, with a diagnosis of MPGN in native kidneys. Data were obtained from medical records during the first 5-year post-transplant follow-up. Primary endpoints were graft function and survival. Secondary endpoints were MPGN recurrence risk factors and these cases' clinical, laboratory, and histological features. RESULTS Twenty-eight patients were included; the majority male (60.7%), with a mean age of 24.0±9.4 years. At MPGN native diagnosis, all patients presented proteinuria, with C3 consumption in 42.9%. Histological analysis showed 13 (42.9%) MPGN type I and 5 (17.9%) type II, with no cases of type III. MPGN recurrence occurred in 7 (25.0%) patients; 85.7% were male, 57.1% were recipients from a living donor, all presenting nephrotic syndrome and hematuria, with C3 consumption in 71.4%. The graft function was similar between the groups. Two (28.6%) patients progressed to graft failure in the recurrence group, and 1 died with a functioning graft. CONCLUSIONS The MPGN recurrence rate was 25%, most of them recipients of kidneys from living donors. Nephrotic syndrome and C3 consumption were frequent at recurrence. The graft function was similar between the groups, and the 5-year graft survival rate in the recurrence group was higher than in other studies.

The effects of DNA profiles: Measuring the effectiveness of DNA banks in criminal investigations in Brazil.

Since 2013, the Brazilian National Bank of Genetic Profiles (BNPG) of the Integrated Network of Genetic Profiles Bank (RIBPG) has been used to aid investigations, identifying who committed a crime based on biological samples found at crime scenes or on victims, which may be substantial evidence in a criminal case. This research evaluates the extent to which the types of genetic profiles and the number of hits influence the number of investigations aided. The study used data from institutions of the RIBPG adopting the period from 2016 to 2020 and organized them in a stacked panel with 98 observations. A regression mediation model was built to estimate the influence of the independent variables "forensic unknown profiles," "profiles of convicted offenders," and "profiles of suspected perpetrators or legal profiles" when mediated by the "hits" variable, influence the increase of the dependent variable "investigations aided," identified as a measure of the effectiveness of the forensic DNA banks. The results showed that the 1% increase in the variables "forensic unknown profiles" and "profiles of suspected perpetrators or legal profiles," mediated by "hits," was significant to produce "investigations aided." As for the variable "profiles of convicted offenders," there was no evidence that it contributed significantly to the increase in "hits" and "investigations aided." The study demonstrated that the increase in "forensic unknown profiles" by 126 and "profiles of suspected perpetrators or legal profiles" by 14 led to 12 "hits" in the RIBPG, offering support to 4 cases. The variable "profiles of convicted offenders" did not show significant results in terms of "hits" and "investigations aided."

Streptococcus constellatus causing concomitant extra and intracranial abscesses complicated with sagittal sinus thrombosis.

Streptococcus constellatus is a gram-positive coccus member of the Streptococcus anginosus group (SAG). It can be found in the oral flora, and may cause abscess more commonly in the gastrointestinal tract, lungs, and heart. Brain abscesses are severe neurological infections with high mortality rates. Streptococcus species other than S. pneumoniae are rare causes of brain abscesses. This case report highlights a severe case of extra and intracranial abscesses due to S. constellatus in an immunocompetent host.

IgA nephropathy and kidney transplantation according to the Oxford classification.

INTRODUCTION: IgA nephropathy (IgAN) is the most common glomerular disease globally, and its susceptibility and the risk for the development of end-stage kidney disease are related to genetic and environmental factors. IgAN recurrence after kidney transplantation is relatively common, impacting graft function and survival. This study evaluated the risk factors and the clinical, laboratory, and histological characteristics of post-transplant IgAN recurrence based on the Oxford classification. MATERIAL AND METHODS: Retrospective single-center cohort study including kidney transplant recipients with biopsy-proven pre-transplantation IgAN, with analysis of risk factors and clinical, laboratory, and histological characteristics of the IgAN recurrence cases. RESULTS: 53 patients fulfilled the inclusion criteria and were included in the study. The majority was male, white, eutrophic, with a mean age of 27 ± 9 years at IgAN diagnosis. Systemic arterial hypertension and proteinuria were frequent in the pretransplant period. Four recipients (7.5%) presented IgAN recurrence in a period of 6 to 122 months post-transplant. According to the Oxford classification, they had high scores of mesangial hypercellularity and segmental glomerulosclerosis in the native kidney biopsies and there was mesangial hypercellularity in all analyzed graft biopsies. None of these patients had received induction immunosuppression and all of them presented graft failure in the follow-up. CONCLUSIONS: In this series, there was a high prevalence of mesangial hypercellularity and segmental glomerulosclerosis on native kidney biopsies, and mesangial hypercellularity occurred in all IgAN recurrence graft biopsies. Despite the lower incidence of recurrence of IgAN post-transplant compared to previous reports, progression to graft loss was of 100%.

Características clínicas e desfecho de pacientes com Covid-19 de um hospital de referência para doenças infectocontagiosas / Clinical characteristics and outcome of patients with covid-19 from a reference hospital for infectious diseases / Características clínicas y evolución de los pacientes con covid-19 de un hospital de referencia para enfermedades infecciosas

Objetivo: descrever as características clínicas, desfechos de mortalidade e alta hospitalar de pacientes com COVID-19. Métodos: estudo observacional retrospectivo com 157 pacientes hospitalizados com a doença por coronavírus. Incluíram-se dados demográficos, clínicos e laboratoriais das fichas de notificação e do prontuário. A análise descritiva foi feita no softwareStata. Resultados: a idade média foi 55,1 anos e 59,2% do sexo masculino. Os sintomas na admissão foram febre (81,5%), dispneia (80,3%) e tosse (77,1%). As comorbidades hipertensão arterial sistêmica (32,5%), diabetes (24,2%) e obesidade (17,2%). Ocorreram desfechos de alta (49,0%), óbito (26,1%) e transferência (24,8%) hospitalar. A idade se relacionou ao desfecho de óbito e alta (p<0,05) e os dias de internação associaram-se à alta (p<0,05). Conclusão: predominaram a alta e óbito. Evidenciou-se que idade >60 anos e os dias de internação apresentaram maior risco de óbito. Contribuições para a prática: os achados contribuem para o avanço do conhecimento na área da saúde e aponta os fatores que inicialmente estavam associados aos desfechos para alta e mortalidade de pacientes com a doença por coronavírus, o que é importante para agilizar o atendimento e os procedimentos.

Objective: to describe the clinical characteristics, mortality outcomes, and hospital discharge of patients with COVID-19. Methods: retrospective observational study with 157 patients hospitalized with coronavirus disease. Demographic, clinical, and laboratory data from notification forms and medical records were included. Descriptive analysis was performed on Stata software. Results: the mean age was 55.1 years and 59.2% were male. Symptoms on admission were fever (81.5%), dyspnea (80.3%) and cough (77.1%). Comorbidities were hypertension (32.5%), diabetes (24.2%), and obesity (17.2%). The outcomes were hospital discharge (49.0%), death (26.1%), and transference (24.8%). Age was associated with death and discharge (p<0.05) and the days of hospitalization were associated with discharge (p<0.05). Conclusion: Discharge and death predominated. It wasevidenced that age >60 years and days of hospitalization presented a higher risk of death. Contributions to practice: the findings contribute to the advancement of knowledge in health care and point out the factors that were initially associated with the outcomes for discharge and mortality of patients with coronavirus disease, which is important to streamline care and procedures.

Objetivo: describir las características clínicas, los resultados de mortalidad y el alta hospitalaria de los pacientes con COVID-19. Métodos: estudio observacional retrospectivo con 157 pacientes hospitalizados por enfermedad por coronavirus. Se incluyeron datos demográficos, clínicos y de laboratorio procedentes de los formularios de notificación y de las historias clínicas. Se realizó un análisis descriptivo con el programa Stata. Resultados: la edad media fue de 55,1 años y el 59,2% eran varones. Los síntomas al ingreso fueron fiebre (81,5%), disnea (80,3%) y tos (77,1%). Las comorbilidades fueron hipertensión arterial sistémica (32,5%), diabetes (24,2%) y obesidad (17,2%). Los desenlaces fueron el alta hospitalaria (49,0%), la muerte (26,1%) y la transferencia (24,8%). La edad se relacionó con la muerte y el alta (p<0,05) y los días de hospitalización se asociaron al alta (p<0,05). Conclusión: Predominaron el alta y la muerte. Evidenciou-se que a idade >60 anos e os dias de internação apresentam maior risco de óbito. Contribuições para a prática: os hallazgos contribuem para o avanço do conhecimento em saúde e aponta os fatores que foram inicialmente associados aos resultados de alta e mortalidade dos pacientes com doença por coronavirus, o que é importante para agilizar os cuidados e procedimentos.

Risk factors for death and illness severity in vaccinated versus unvaccinated COVID-2019 inpatients: a retrospective cohort study / Fatores de risco para óbito e gravidade da doença em pacientes internados com COVID-19 vacinados e não vacinados: estudo de coorte retrospectivo

ABSTRACT Objective: To determine the clinical profile of COVID-19 inpatients who were vaccinated prior to hospitalization and to compare the risk factors for death and the 28-day survival rate of between those inpatients vaccinated with one, two, or three doses and unvaccinated COVID-19 inpatients. Methods: This was a retrospective observational cohort study involving COVID-19 patients admitted to a referral hospital in the city of Recife, Brazil, between July of 2020 and June of 2022. Results: The sample comprised 1,921 inpatients, 996 of whom (50.8%) were vaccinated prior to hospitalization. After adjusting the mortality risk for vaccinated patients, those undergoing invasive mechanical ventilation (IMV) had the highest mortality risk (adjusted OR [aOR] = 7.4; 95% CI, 3.8-14.1; p < 0.001), followed by patients > 80 years of age (aOR = 7.3; 95% CI, 3.4-15.4; p < 0.001), and those needing vasopressors (aOR = 5.6; 95% CI, 2.9-10.9; p < 0.001). After adjusting the mortality risk for all patients, having received three vaccine doses (aOR = 0.06; 95% CI, 0.03-0.11; p < 0.001) was the most important protective factor against death. There were progressive benefits of vaccination, reducing the frequency of ICU admissions, use for IMV, and death (respectively, from 44.9%, 39.0% and 39.9% after the first dose to 16.7%, 6.2% and 4.4% after the third dose), as well as significant improvements in survival after each subsequent dose (p < 0.001). Conclusions: Vaccines were effective in reducing illness severity and death in this cohort of COVID-19 inpatients, and the administration of additional doses conferred them with accumulative vaccine protection.

RESUMO Objetivo: Traçar o perfil clínico de pacientes internados com COVID-19 que haviam sido vacinados antes da hospitalização e comparar os fatores de risco para óbito e a taxa de sobrevida em 28 dias entre esses internados vacinados com uma, duas ou três doses e pacientes internados com COVID-19 não vacinados. Métodos: Estudo de coorte observacional retrospectivo envolvendo pacientes com COVID-19 internados em um hospital de referência na cidade do Recife (PE) entre julho de 2020 e junho de 2022. Resultados: A amostra foi composta por 1.921 pacientes internados, dos quais 996 (50,8%) haviam sido vacinados antes da hospitalização. Após ajuste do risco de mortalidade para os pacientes vacinados, aqueles submetidos à ventilação mecânica invasiva (VMI) apresentaram o maior risco de mortalidade (OR ajustada [ORa] = 7,4; IC95%: 3,8-14,1; p < 0,001), seguidos pelos pacientes > 80 anos (ORa = 7,3; IC95%: 3,4-15,4; p < 0,001) e aqueles que necessitam de vasopressores (ORa = 5,6; IC95%: 2,9-10,9; p < 0,001). Após ajuste do risco de mortalidade para todos os pacientes, o recebimento de três doses de vacina (ORa = 0,06; IC95%: 0,03-0,11; p < 0,001) foi o fator de proteção mais importante contra o óbito. Houve benefícios progressivos da vacinação, com redução da frequência de internações em UTI, de uso de VMI e de óbitos (de 44,9%, 39,0% e 39,9% após a primeira dose para 16,7%, 6,2% e 4,4% após a terceira dose, respectivamente), bem como melhora significativa na sobrevida após cada dose subsequente (p < 0,001). Conclusões: As vacinas foram efetivas na redução da gravidade da doença e dos óbitos nesta coorte de pacientes internados com COVID-19, e a aplicação de doses adicionais conferiu-lhes proteção vacinal cumulativa.

A visão de gerentes de atenção básica à saúde sobre suas atribuições / The perspective of primary health care managers about their attributions

Resumo O artigo objetivou compreender o desenvolvimento das atribuições do gerente de atenção básica a partir da perspectiva desses mesmos profissionais, na capital Maceió, Alagoas, Brasil. Trata-se de pesquisa qualitativa, que entrevistou a oito gerentes de Unidades Básicas de Saúde e tratado por meio da análise de conteúdo. Os resultados identificaram que os gerentes, como rotina, administram o fluxo assistencial e o registro de frequência dos membros da equipe, mas apresentam limitações para gerir o trabalho em equipe e a estrutura física. Em nível institucional, mediam a relação dos profissionais da equipe com a sede administrativa, porém demostram escassa participação no estabelecimento de ações intersetoriais. Valorizam a relação com a comunidade, no entanto, relatam haver pouca participação social no âmbito das Unidades. Demonstram, ainda, pouco conhecimento sobre as políticas e sistemas de informação em saúde. Considera-se que, para um impacto positivo no acesso e na qualidade à saúde da população, é necessária: a garantida da governabilidade dos gerentes sobre os recursos materiais e da gestão de pessoal; o monitoramento das metas de saúde com a participação colaborativa da comunidade; apropriação e fomento das redes de trabalho em saúde; e um programa de formação em serviço que auxilie a gestão local.

Abstract The article aimed to understand the development of the attributions of the primary care manager from the perspective of these same professionals, in the capital Maceió, Alagoas, Brazil. It is a qualitative research, which interviewed eight managers of Basic Health Units and treated by means of content analysis. The results identified that the managers as routine manage the flow of care and the attendance record of the team members, but present limitations to manage the teamwork and the physical structure. At the institutional level, they mediate the relationship of the team's professionals with the administrative headquarters, but show little participation in the establishment of intersectoral actions. They value the relationship with the community, however, they report little social participation at the Unit level. They show little knowledge about health policies and information systems. It is considered that, for a positive impact on access and quality to the health of the population, it is necessary: to guarantee the governability of managers over material resources and personnel management; the monitoring of health goals with the collaborative participation of the community; the appropriation and promotion of health work networks; and an in-service training program that helps local management.

Streptococcus constellatus causing concomitant extra and intracranial abscesses complicated with sagittal sinus thrombosis

ABSTRACT Streptococcus constellatus is a gram-positive coccus member of the Streptococcus anginosus group (SAG). It can be found in the oral flora, and may cause abscess more commonly in the gastrointestinal tract, lungs, and heart. Brain abscesses are severe neurological infections with high mortality rates. Streptococcus species other than S. pneumoniae are rare causes of brain abscesses. This case report highlights a severe case of extra and intracranial abscesses due to S. constellatus in an immunocompetent host

Contracepção e poder na decisão sobre maternidade de mulheres vivendo com hiv: revisão integrativa / Contraception and decision-making power in women living with hiv: integrative review / Contracepción y poder en la decisión sobre la maternidad de las mujeres que viven con el vih: examen integrativo

Objetiva-se identificar as práticas contraceptivas e quais motivos influenciam na decisão reprodutiva de mulheres vivendo com HIV. Revisão integrativa da literatura com estudos primários publicados na íntegra, sem restrição de tempo e idioma, de dezembro de 2022 a março de 2023 nas bases de dados Medical Literature Analysis and Retrieval System Online, via National Library of Medicine, Scopus, Embase, PsycINFO, Science Direct Journals e Web of Science. Foram incluídos 32 estudos com base nos tipos de contraceptivos usados por mulheres com HIV e seu poder e desejo na decisão sobre ter filhos: "métodos contraceptivos modernos", englobando principalmente contraceptivos hormonais orais e injetáveis, além de preservativos (78,2%); "métodos contraceptivos naturais", incluindo em sua maioria o método rítmico e coito interrompido (21,8%); e "poder e desejo reprodutivo", referindo nestes influência da família, da comunidade, religião e cultura, do parceiro, e de profissionais da saúde. O nível de evidência da maioria dos estudos foi IV. Assim, o uso de contraceptivos por MVHIV mais comuns são os métodos modernos do tipo hormonais orais e injetáveis e métodos comportamentais. Quanto as influências sobre o poder e desejo reprodutivo, estes podem refletir as desigualdades de gênero, controle e submissão feminina que podem ocasionar comportamentos sexuais de risco.

The objective is to identify contraceptive practices and which reasons influence the reproductive decision of women living with HIV. Integrative literature review with primary studies published in full, without time and language restriction, from December 2022 to March 2023 in the Medical Literature Analysis and Retrieval System Online databases, via National Library of Medicine, Scopus, Embase, PsycINFO, Science Direct Journals and Web of Science. We included 32 studies based on the types of contraceptives used by women with HIV and their power and desire in deciding to have children: "modern contraceptive methods", mainly encompassing oral and injectable hormonal contraceptives, plus condoms (78.2%); "natural contraceptive methods", including mostly rhythmic method and interrupted coitus (21.8%); and "reproductive power and desire", referring in these influences of family, community, religion and culture, partner, and health professionals. The level of evidence from most studies was IV. Thus, the most common use of MVHIV contraceptives are modern oral and injectable hormone- like methods and behavioral methods. As for the influences on reproductive power and desire, these may reflect the inequalities of gender, control, and female submission that can cause risky sexual behavior.

Su objetivo es identificar las prácticas anticonceptivas y las razones por las que las mujeres que viven con el VIH tienen una decisión reproductiva. Una revisión integral de la literatura con estudios primarios publicados en su totalidad, sin restricciones de tiempo e idioma, de diciembre de 2022 a marzo de 2023 en las bases de datos del Sistema de Análisis y Recuperación de Literatura Médica Online, a través de la Biblioteca Nacional de Medicina, Scopus, Embase, PsycINFO, Science Direct Journals y Web of Science. Se incluyeron 32 estudios basados en los tipos de anticonceptivos utilizados por las mujeres con VIH y su poder y deseo en la decisión de tener hijos: "métodos anticonceptivos modernos", que abarcan principalmente anticonceptivos hormonales orales e inyectables, así como preservativos (78,2%); "métodos anticonceptivos naturales", principalmente el método rítmico y omnipresente (21,8%); y "anticonceptivos naturales"; poder y deseo", refiriéndose a estas influencias de la familia, la comunidad, la religión y la cultura, el compañero y los profesionales de la salud. El nivel de evidencia para la mayoría de los estudios fue IV. Por lo tanto, el uso de anticonceptivos MVHIV que son más comunes son métodos y métodos de comportamiento orales e inyectables modernos. En cuanto a las influencias sobre el poder y el deseo reproductivos, éstas pueden reflejar las desigualdades de género, control y sumisión que pueden generar conductas sexuales riesgosas.

Deduction, Induction and the Art of Clinical Reasoning in Medical Education: Systematic Review and Bayesian Proposal. / Dedução, Indução e a Arte do Raciocínio Clínico na Educação Médica: Revisão Sistemática e Proposta Bayesiana.

BACKGROUND: Clinical reasoning is at the core of medical practice and entangled in a conceptual confusion. The duality theory in probability allows to evaluate its objective and subjective aspects. OBJECTIVES: To conduct a systematic review of the literature about clinical reasoning in decision making in medical education and to propose a "reasoning based on the Bayesian rule" (RBBR). METHODS: A systematic review on PubMed was conducted (until February 27, 2022), following a strict methodology, by a researcher experienced in systematic review. The RBBR, presented in the discussion section, was constructed in his undergraduate dissertation in Philosophy at Minas Gerais Federal University. Heart failure was used as example. RESULTS: Of 3,340 articles retrieved, 154 were included: 24 discussing the uncertainty condition, 87 on vague concepts (case discussion, heuristics, list of cognitive biases, choosing wisely) subsumed under the term "art", and 43 discussing the general idea of inductive or deductive reasoning. RBBR provides coherence and reproducibility rules, inference under uncertainty, and learning rule, and can incorporate those vague terms classified as "art", arguments and evidence, from a subjective perspective about probability. CONCLUSIONS: This systematic review shows that reasoning is grounded in uncertainty, predominantly probabilistic, and reviews possible errors of the hypothetico-deductive reasoning. RBBR is a two-step probabilistic reasoning that can be taught. The Bayes theorem is a linguistic tool, a general rule of reasoning, diagnosis, scientific communication and review of medical knowledge according to new evidence.

FUNDAMENTO: O raciocínio clínico está no centro da prática médica e emaranhado em uma confusão conceitual.A teoria da dualidade da probabilidade permite analisar seus aspectos objetivos e subjetivos. OBJETIVOS: Fazer revisão sistemática da literatura sobre o raciocínio clínico para tomada de decisão na educação médica e uma proposta chamada "Pensamento Conforme a Regra de Bayes" (PCRB). MÉTODOS: A revisão sistemática foi realizada na base PubMed até a data de 27/02/2022, seguindo metodologia rigorosa, por pesquisador experiente em revisão sistemática. A proposta PCRB, apresentada na discussão, foi elaborada no trabalho de conclusão de graduação em Filosofia na Universidade Federal de Minas Gerais. Usou-se a insuficiência cardíaca como exemplo. RESULTADOS: De 3340 artigos encontrados, incluíram-se 154 artigos: 24 tratando da condição de incerteza; 87 tratando de conceitos vagos (discussão de casos, heurística, lista de vieses cognitivos, escolha com sabedoria) incluídos sob o termo 'arte'; e 43 discutindo a ideia geral de raciocínio indutivo ou dedutivo. PCRB oferece regras de coerência e reprodutibilidade, inferência sob incerteza e regra de aprendizado, e pode, por meio da perspectiva subjetiva sobre a probabilidade, incorporar aqueles termos vagos classificados como 'arte', bem como argumentos e evidências. CONCLUSÕES: A revisão sistemática mostra que o raciocínio é fundado na incerteza, predominantemente probabilístico; além de mostrar algumas possibilidades de erro do pensamento hipotético-dedutivo. O PCRB é um pensamento probabilístico em duas etapas que pode ser ensinado. A regra de Bayes é uma ferramenta linguística, uma regra geral de raciocínio, de diagnóstico, de comunicação científica e de revisão do conhecimento médico conforme novas evidências.

Dedução, Indução e a Arte do Raciocínio Clínico na Educação Médica: Revisão Sistemática e Proposta Bayesiana / Deduction, Induction and the Art of Clinical Reasoning in Medical Education: Systematic Review and Bayesian Proposal

Resumo Fundamento O raciocínio clínico está no centro da prática médica e emaranhado em uma confusão conceitual.A teoria da dualidade da probabilidade permite analisar seus aspectos objetivos e subjetivos. Objetivos Fazer revisão sistemática da literatura sobre o raciocínio clínico para tomada de decisão na educação médica e uma proposta chamada "Pensamento Conforme a Regra de Bayes" (PCRB). Métodos A revisão sistemática foi realizada na base PubMed até a data de 27/02/2022, seguindo metodologia rigorosa, por pesquisador experiente em revisão sistemática. A proposta PCRB, apresentada na discussão, foi elaborada no trabalho de conclusão de graduação em Filosofia na Universidade Federal de Minas Gerais. Usou-se a insuficiência cardíaca como exemplo. Resultados De 3340 artigos encontrados, incluíram-se 154 artigos: 24 tratando da condição de incerteza; 87 tratando de conceitos vagos (discussão de casos, heurística, lista de vieses cognitivos, escolha com sabedoria) incluídos sob o termo 'arte'; e 43 discutindo a ideia geral de raciocínio indutivo ou dedutivo. PCRB oferece regras de coerência e reprodutibilidade, inferência sob incerteza e regra de aprendizado, e pode, por meio da perspectiva subjetiva sobre a probabilidade, incorporar aqueles termos vagos classificados como 'arte', bem como argumentos e evidências. Conclusões A revisão sistemática mostra que o raciocínio é fundado na incerteza, predominantemente probabilístico; além de mostrar algumas possibilidades de erro do pensamento hipotético-dedutivo. O PCRB é um pensamento probabilístico em duas etapas que pode ser ensinado. A regra de Bayes é uma ferramenta linguística, uma regra geral de raciocínio, de diagnóstico, de comunicação científica e de revisão do conhecimento médico conforme novas evidências.

Abstract Background Clinical reasoning is at the core of medical practice and entangled in a conceptual confusion. The duality theory in probability allows to evaluate its objective and subjective aspects. Objectives To conduct a systematic review of the literature about clinical reasoning in decision making in medical education and to propose a "reasoning based on the Bayesian rule" (RBBR). Methods A systematic review on PubMed was conducted (until February 27, 2022), following a strict methodology, by a researcher experienced in systematic review. The RBBR, presented in the discussion section, was constructed in his undergraduate dissertation in Philosophy at Minas Gerais Federal University. Heart failure was used as example. Results Of 3,340 articles retrieved, 154 were included: 24 discussing the uncertainty condition, 87 on vague concepts (case discussion, heuristics, list of cognitive biases, choosing wisely) subsumed under the term "art", and 43 discussing the general idea of inductive or deductive reasoning. RBBR provides coherence and reproducibility rules, inference under uncertainty, and learning rule, and can incorporate those vague terms classified as "art", arguments and evidence, from a subjective perspective about probability. Conclusions This systematic review shows that reasoning is grounded in uncertainty, predominantly probabilistic, and reviews possible errors of the hypothetico-deductive reasoning. RBBR is a two-step probabilistic reasoning that can be taught. The Bayes theorem is a linguistic tool, a general rule of reasoning, diagnosis, scientific communication and review of medical knowledge according to new evidence.