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Virol J ; 15(1): 23, 2018 01 25.
Artigo em Inglês | MEDLINE | ID: mdl-29370812

RESUMO

BACKGROUND: Zika virus is an emerging arbovirus of the family Flaviviridae and genus Flavivirus that until 2007 was restricted to a few cases of mild illness in Africa and Asia. CASE PRESENTATION: We report a case of atrial fibrillation disclosed during an acute Zika virus infection in a 49-year-old man. Different biological samples were analyzed for the molecular diagnosis of Zika by real-time PCR, however only the saliva specimen was positive. The patient's wife tested positive in the serum sample, although she was an asymptomatic carrier. Moreover, a complete overview of patient's biomarkers, including cytokines, chemokines, and growth-factors levels, was analyzed and compared to gender and age matching non-infected controls, as well as other Zika infected patients, considering the 95%CI of the mean values. Elevated levels of CXCL8, CCL11, CCL2, CXCL10, IL-1ß, IL-6, TNF-α, IFN-γ, IL-17, IL-1Ra, IL-4, IL-9, FGF-basic, PDGF, G-CSF, and GM-CSF were observed in the Atrial fibrillation patient, in contrast to uninfected controls. Furthermore, increased levels of CCL5, IL-1ß, TNF-α, IFN-γ, IL-9, G-CSF, and GM-CSF were observed only in the atrial fibrillation patient, when compared to other Zika patients. CONCLUSIONS: To our knowledge, this is the first description of this type of cardiac disorder in Zika patients which may be considered another atypical manifestation during Zika virus infection.


Assuntos
Fibrilação Atrial/diagnóstico , Fibrilação Atrial/etiologia , Infecção por Zika virus/complicações , Infecção por Zika virus/virologia , Zika virus , Fibrilação Atrial/metabolismo , Biomarcadores , Citocinas/metabolismo , Eletrocardiografia , Testes de Função Cardíaca , Humanos , Mediadores da Inflamação , Masculino , Pessoa de Meia-Idade , Radiografia Torácica , Zika virus/classificação , Zika virus/genética
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