RESUMO
OBJECTIVE: The study was aimed to search for correlation between parameters of surface electromyography and acid-base balance (ABB) in patients with intensive care unit-acquired weakness (ICUAW, n = 29, duration 7-180 days). METHODS: The linear and nonlinear parameters of sEMG (mean frequency of spectrum, fractal and correlation dimension, correlation entropy) and ABB and their correlation coefficient with bed rest (BR) and duration of mechanical ventilation (MT) were computed. RESULTS: Here we report that in first 40 days sEMG parameters were indicative of the neurogenic process in the skeletal muscle, while within 41-100 days signs of the myogenic pathology were documented. The ABB parameters statistically signIficantly correlated with BR and MV duration. CONCLUSION: ICUAW exerts effect on the skeletal muscle. Within first 40 days this effect is actuated in a form of neuropathy, while further it has signs of myopathy. We argue that MV duration appear to be a pathogenic factor in these modifications.
Assuntos
Equilíbrio Ácido-Base , Eletromiografia , Unidades de Terapia Intensiva , Debilidade Muscular/diagnóstico , Músculo Esquelético/fisiopatologia , Respiração Artificial/efeitos adversos , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Debilidade Muscular/etiologia , Debilidade Muscular/metabolismo , Fatores de TempoRESUMO
The article is devoted to the actual problem--poisoning by calcium channel blockers. The case of the departure of the patient amlodipine, clinical picture, treatment and its effectiveness. In the discussion described pharmacological characteristics of the group of calcium channel blockers, mechanisms of development syndromes developing in this type of shipment and pathogenetic approach to therapy.