Hemodynamic Evaluation of a Centrifugal Left Atrial Decompression Pump for Heart Failure with Preserved Ejection Fraction.

This article discusses a new continuous flow mini pump that has been developed to improve symptoms and prognosis in patients with Heart Failure with Preserved Ejection Fraction (HFpEF), for which there are currently no established treatments. The pump is designed to discharge a reduced percentage of blood volume from the left atrium to the subclavian artery, clamped at the bifurcation with the aortic arch. The overall specifications, design parameters, and hemodynamics of this new device are discussed, along with data from in vitro circulation loop tests and numerical simulations. The article also compares the results for two configurations of the pump with respect to key indicators of hemocompatibility used in blood pump development.

Numerical Assessment of the Hydrodynamic Behavior of a Volute Centrifugal Pump Handling Emulsion.

Although emulsion pumping is a subject of growing interest, a detailed analysis of the fluid dynamic phenomena occurring inside these machines is still lacking. Several computational investigations have been conducted to study centrifugal pumps carrying emulsion by analyzing their overall performance, but no studies involved the rheological behavior of such fluids. The purpose of this study is to perform a computational analysis of the performance and flow characteristics of a centrifugal pump with volute handling emulsions and oil-water mixtures at different water cuts modeled as a shear-thinning non-Newtonian fluid. The studied pump consists of a five-bladed backward curved impeller and a volute and has a specific speed of 32 (metric units). The rheological properties of the mixtures studied were measured experimentally under a shear rate ranging from 1 s-1 to 3000 s-1 and were fitted to conventional Cross and Carreau effective viscosity models. Numerical results showed the flow topology in the pump is directly related to the viscosity plateau of the pseudoplastic behavior of emulsions. The viscosity plateau governs pump performance by influencing the loss mechanisms that occur within the pump. The larger the ν∞, the less recirculation loss the fluid experiences, and conversely, the smaller the value of ν0, the less friction loss the fluid experiences.

The evolution of long-term pediatric ventricular assistance devices: a critical review.

Introduction: The gap between the number of heart failure patients and the number of potential heart donors has never been larger than today, especially among the pediatric population. The use of mechanical circulatory support is seen as a potential alternative for clinicians to treat more patients. This treatment has proven its efficiency on short-term use. However, in order to replace heart transplant, the techniques should be used over longer periods of time.Areas covered: This review aims at furnishing an engineering vision of the evolution of ventricular assistance devices used in pediatrics. A critical analysis of the clinical complications related to devices generation is made to give an overview of the design improvements made since their inception.Expert opinion: The long-term use of a foreign device in the body is not without consequences, especially among fragile pediatric patients. Moreover, the size of their body parts increases the technical difficulties of such procedure. The balance between the living cells of the body is disturbed by the devices, mostly by the shear stress generated. To provide a safe mechanical circulatory support for long-term use, the devices should be more hemocompatible, preserving blood cells, adapted to the patient's systemic grid and miniaturized for pediatric use.