RESUMO
The objective of this randomized controlled trial was to assess the effects of a 1-year behavioral contract intervention on immunosuppressant therapy (IST) adherence and healthcare utilizations and costs among adult renal transplant recipients (RTRs). The sample included adult RTRs who were at least 1 year posttransplant, taking tacrolimus or cyclosporine and served by a specialty pharmacy. Pharmacy refill records were used to measure adherence and monthly questionnaires were used to measure healthcare utilizations. Direct medical costs were estimated using the 2009 Medicare Expenditure Panel Survey. Adherence was analyzed using the GLM procedure and the MIXED procedure of SAS. Rate ratios and 95% confidence intervals were estimated to quantify the rate of utilizing healthcare services relative to treatment assignment. One hundred fifty RTRs were enrolled in the study. Intervention group RTRs (n = 76) had higher adherence than control group RTRs (n = 74) over the study period (p < 0.01). And 76.1% of the intervention group compared with 42.7% of the control group was not hospitalized during the 1-year study period (RR = 1.785; 95% CI: 1.314, 2.425), resulting in cost savings. Thus, evidence supports using behavioral contracts as an effective adherence intervention that may improve healthcare outcomes and lower costs.
Assuntos
Terapia Comportamental , Ciclosporina/uso terapêutico , Imunossupressores/administração & dosagem , Transplante de Rim , Cooperação do Paciente/estatística & dados numéricos , Tacrolimo/uso terapêutico , Adulto , Idoso , Feminino , Serviços de Saúde/estatística & dados numéricos , Humanos , Masculino , Adesão à Medicação , Pessoa de Meia-IdadeRESUMO
The study objective was to determine the association between immunosuppressant therapy (IST) adherence and graft failure among pediatric renal transplant recipients (RTRs) using data reported in the United States Renal Data System (USRDS), which contains Medicare prescription claims. RTRs (Assuntos
Ciclosporina/uso terapêutico
, Rejeição de Enxerto/tratamento farmacológico
, Rejeição de Enxerto/epidemiologia
, Imunossupressores/uso terapêutico
, Transplante de Rim/estatística & dados numéricos
, Adesão à Medicação/estatística & dados numéricos
, Adolescente
, Criança
, Prescrições de Medicamentos/estatística & dados numéricos
, Feminino
, Sobrevivência de Enxerto
, Humanos
, Estimativa de Kaplan-Meier
, Masculino
, Medicare/estatística & dados numéricos
, Modelos de Riscos Proporcionais
, Tacrolimo/uso terapêutico
, Estados Unidos/epidemiologia
Assuntos
Compreensão , Educação em Saúde , Pessoal de Saúde , Transplante de Rim , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estados UnidosRESUMO
OBJECTIVES: To determine the smoking cessation/reduction services offered to pregnant women by federally funded Healthy Start projects designed to reduce infant mortality. DESIGN: Information was obtained by questionnaires sent to all Healthy Start projects in 1999. Responses were received from 76 sites. SETTING: The federal government selected the Healthy Start sites on the basis of infant mortality rates that were much in excess of the national average. PATIENTS: The projects served largely minority clients. Most of the women were poor and eligible for Medicaid. MAIN OUTCOME MEASURES: The services that projects offered to pregnant smokers, the priority given the smoking related activities, and whether more should be done. RESULTS: Only 23% of the sites thought that they were doing enough to help pregnant smokers stop or reduce smoking. The sites felt the national office should develop a manual of best practices, provide client materials, and organise workshops. While three quarters of the sites expected home visitors to counsel pregnant smokers, less than half provided training in this area during orientation, but most visitors received on-the-job training. Only 64% of sites gave smoking cessation/reduction activities high priority in comparison to other objectives of home visiting. CONCLUSIONS: Although Healthy Start sites were aware of the importance of smoking cessation/reduction activities for their clients, they offered a limited range of services. These projects, and others with similar objectives serving similar populations, need a better understanding of the time and money such interventions require and greater belief in their effectiveness, along with more funds, staff training and materials, and office systems that promote counselling.
Assuntos
Financiamento Governamental , Abandono do Hábito de Fumar , Prevenção do Hábito de Fumar , Aconselhamento , Feminino , Promoção da Saúde , Humanos , Medicaid , Gravidez , Cuidado Pré-Natal , Fatores de Risco , Inquéritos e Questionários , Estados UnidosRESUMO
Serum concentrations of alpha 1-acid glycoprotein (AAG) were studied in nine healthy women at four times in their menstrual cycles. AAG concentrations were significantly higher on day 4 than on days 12, 20, and 28 (with the first day of menstrual flow considered to be day 1). The mean AAG concentration (mg dl-1) on day 4 was 78.55 +/- 5.03 (mean +/- s.e. mean), 70.19 +/- 4.80 on day 12, 70.63 +/- 6.67 on day 20, and 70.40 +/- 5.97 on day 28. Although these results should be considered preliminary because of the small sample size, we conclude that physiologic changes over the course of the menstrual cycle may affect serum AAG concentrations. Since AAG is a major binding protein for several important drugs, the potential exists for altered drug binding and drug effects, and further study of individual drugs is justified.
Assuntos
Ciclo Menstrual/fisiologia , Orosomucoide/metabolismo , Adulto , Feminino , HumanosAssuntos
Disfunção Erétil/tratamento farmacológico , Papaverina/administração & dosagem , Fentolamina/administração & dosagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Assistência Ambulatorial , Quimioterapia Combinada , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Pênis , AutoadministraçãoRESUMO
The authors identify program characteristics most predictive of cost in 13 residential treatment facilities for emotionally disturbed children and discuss how easily obtainable quantitative information can be used to decide resource allocation.
Assuntos
Terapia Comportamental/economia , Transtornos Mentais/terapia , Instituições Residenciais/economia , Criança , Custos e Análise de Custo , Educação Inclusiva , Humanos , Transtornos Mentais/economia , Participação do Paciente , Estados UnidosRESUMO
Occupational exposure to asbestos has been epidemiologically associated with carcinoma of the larynx; however, no search for or quantitation of laryngeal asbestos bodies has been performed. This report concerns an autopsy study of five patients with occupational asbestos exposure and proven asbestos-associated pulmonary disease in whom histologic sections of the larynx were examined and a digestion-concentration technique was used to isolate and quantitate the asbestos bodies in the remaining laryngeal tissues. No dysplastic epithelial changes were present in the mucosa. Asbestos bodies were recovered from two of the five larynges but from none of ten larynges obtained from autopsy controls.
Assuntos
Amianto/análise , Neoplasias Laríngeas/análise , Laringe/análise , Doenças Profissionais/patologia , Idoso , Amianto/efeitos adversos , Asbestose/patologia , Autopsia , Humanos , Neoplasias Laríngeas/etiologia , Neoplasias Laríngeas/patologia , Laringe/patologia , Pulmão/patologia , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/etiologia , Fumar/complicaçõesRESUMO
The Tyler Asbestos Workers Program is a continuing study of 1,105 former amosite asbestos workers. This report includes a study of six former workers, five of whom died and had autopsies, and one who underwent a lobectomy. Five of these men were exposed to asbestos for three months or less. Four had lung cancer, and one a rectal carcinoma. All were cigarette smokers. Ferruginous (asbestos) body content of the upper and lower lobes of the lungs was quantitated by a digestion technic. Tissue sections from upper and lower lobes were independently quantitated for fibrosis and ferruginous bodies, and chest roentgenograms were examined for interstitial fibrosis. (Control lung tissue was obtained from consecutive autopsies of 52 adults who did not have a known occupational exposure to asbestos.) Relatively low ferruginous body counts (less than 700/g lung tissue) were associated with mild degrees of fibrosis, and higher counts (greater than 10,000/g) with moderate to severe fibrosis. Mild to moderate pulmonary fibrosis could be identified on tissue sections before interstitial changes were detectable by chest roentgenograms.
Assuntos
Amianto/efeitos adversos , Carcinoma Broncogênico/patologia , Neoplasias Pulmonares/patologia , Pulmão/análise , Doenças Profissionais/patologia , Fibrose Pulmonar/patologia , Neoplasias Retais/patologia , Idoso , Humanos , Pulmão/patologia , Masculino , Pessoa de Meia-Idade , Tamanho do Órgão , Fumar/complicações , Difração de Raios XRESUMO
The clinical significance of ferruginous bodies in sputa was examined in a study of 674 former asbestos workers. Data from occupational histories and smoking behavior questionnaires, chest radiographs, spirometric measurements and counts of ferruginous bodies were obtained as part of a five-year surveillance program. Statistical analysis demonstrated that ferruginous bodies found in the sputa were significantly related to radiographic findings of interstitial pulmonary disease and pleural fibrosis and to spirometric findings of restrictive lung disease. Age and cigarette smoking were also found to be related to the presence of ferruginous bodies.
Assuntos
Asbestose/diagnóstico , Ferro/análise , Escarro/análise , Adulto , Asbestose/patologia , Emprego , Humanos , Pleura/patologia , Fumar , Capacidade VitalRESUMO
An asbestos-exposed worker who smokes cigarettes has a high risk of developing cancer of the lung. One thousand ninety-five former workers at a plant manufacturing asbestos (amosite) insulation products were exposed to high levels of asbestos dust concentrations in the atmosphere. The workers have been identified and located. A semi-annual medical surveillance program has been developed with National Cancer Institute support. Examination of the worker includes the following: history (questionnaire), physical examination, sputum cytopathology, chest roentgenogram, pulmonary function studies, and other tests. Emphasis has been placed on understanding the role of sputum cytopathology in a cancer control program in former asbestos workers.
Assuntos
Amianto/efeitos adversos , Neoplasias Pulmonares/prevenção & controle , Doenças Profissionais/prevenção & controle , Vigilância da População/métodos , Adulto , Idoso , Humanos , Neoplasias Pulmonares/etiologia , Neoplasias Pulmonares/patologia , Pessoa de Meia-Idade , Doenças Profissionais/etiologia , Doenças Profissionais/patologia , Escarro/citologia , TexasRESUMO
Routine cytopathologic examinations were performed at six-month intervals on sputum specimens from 628 former asbestos workers and 138 control patients. The occurrence of ferruginous bodies in sputa is found to increase as a logarithmic function of the length of occupational exposure to asbestos in workdays. No significant association is found between the occurrence of ferruginous bodies and the worker's age, smoking history, degree of cellular epithelial atypia, or time since last exposure. We conclude that the presence of ferruginous bodies in sputa is evidence of probable significant occupational exposure to asbestos dust. Their absence does not indicate lack of exposure. We can also conclude that routine cytopathology procedures are sufficient for the detection of ferruginous bodies in sputa.
Assuntos
Amianto , Macrófagos/ultraestrutura , Escarro/citologia , Exposição Ambiental , Humanos , Macrófagos/análise , Masculino , Alvéolos Pulmonares/ultraestrutura , Fumar/epidemiologiaRESUMO
Three thousand patients with primary carcinoma of the lung entered in the Armed Forces Central Medical Registry are reported. Forty-one per cent had squamous cell, 28.5 per cent adenocarcinoma, 25.2 per cent small cell/undifferentiated, and 4.9 per cent miscellaneous cell types. When first seen, 71.1 per cent had no organ metastases and 50.6 per cent no lymph node metastases. Over-all survival rate was 18.2 per cent at 5 years and 14.5 per cent at 10 years. Survival following definitive resection, palliative resection, definitive radiation, palliative radiation, and chemotherapy was determined both in the presence of mediastinal nodal involvement and in the absence of mediatinal nodal involvement. Where resection for cure could be carried out, 5 year survival rates of 48.8 per cent were possible. The factors affecting this improved outlook in our military population are discussed and, in general, appear to be related to a ready accessibility of medical care and the necessity, because of global commitments, of establishing an early diagnosis. Cell type ecerted some influence on survival, but the major determinant appeared to be the absence of involved nodes at the time of the operation.