RESUMO
There are advantages and disadvantages to all animal models for aging research. Investigators need to understand these issues, as well as the nature of each relevant model, to choose the best model for their research. There is no, "best" or "worst" model for aging research. Five genetically defined rodent models of potential utility in aging research are: (1) inbred strains and F1 hybrid mice and rats, (2) single gene mutations and other single locus effects, (3) congenic lines, (4) recombinant Inbred (RI) strains, and (5) genetically selected strains and stocks. Animals of each of these types are available for research, but only inbred and F1 hybrid mice and rats are commercially available as aged animals. A genetic understanding of the need for careful genetic definition and for the best available barriér-breeding facilities has improved the quality of aging research significantly in the last one decades.
Assuntos
Envelhecimento/genética , Genótipo , Camundongos Endogâmicos/genética , Ratos Endogâmicos/genética , Animais , Mapeamento Cromossômico , Hibridização Genética , Camundongos , Ratos , Recombinação Genética , Especificidade da EspécieRESUMO
Current data suggest that the life spans of commonly held rodent species have decreased and the occurrence of tumors occurs earlier in the lifespan of ad libitum-fed animals. The most likely cause of this change in the life span of barrier-reared genetically defined animals is increased body weight. The effects of caloric restriction on a variety of functional measures and on age-dependent tumors and lesions are the focus of this presentation. Recommendations for caloric restriction, or at least "dietary control," will be discussed.
Assuntos
Dieta , Ingestão de Energia , Longevidade/fisiologia , Animais , Peso Corporal/fisiologia , Feminino , Masculino , Camundongos , Camundongos Endogâmicos , Ratos , Ratos EndogâmicosAssuntos
Dieta , Longevidade/fisiologia , Animais , Arkansas , Biomarcadores , Dieta/economia , Dieta/métodos , Comportamento Alimentar , HumanosRESUMO
There are advantages and disadvantages to all animal models for aging research. Investigators need to understand these issues as well as the nature of each relevant model, in order to choose the best model for their research. There is no "best" or "worst" model for aging research. Five genetically defined rodent models of potential utility in aging research are: 1. Inbred strains and F1 Hybrid mice and rats; 2. Single gene mutations and other single locus effects; 3. Congenic lines; 4. Recombinant Inbred (RI) strains; 5. Genetically selected strains and stocks. Animals of each of these types are available for research, but only inbred and F1 hybrid mice and rats are commercially available as aged animals. A general understanding of the need for careful genetic definition and for the best available barrier-breeding facilities has improved the quality of aging research significantly in the last two decades.
Assuntos
Envelhecimento/genética , Camundongos/genética , Ratos/genética , Animais , Genótipo , Humanos , Hibridização Genética , Camundongos Endogâmicos , Camundongos Mutantes , Modelos Biológicos , Ratos Endogâmicos , Ratos Mutantes , Recombinação GenéticaRESUMO
The suitability of various animal species as experimental models of aging has been a continuing concern of the National Institute on Aging (NIA) for over 20 years. The history of the decisions made by NIA in providing aged animals for research may be helpful to individual investigators seeking to understand why certain models are available and which of them to choose for their work.
Assuntos
Envelhecimento/fisiologia , Animais , Humanos , Modelos Biológicos , National Institutes of Health (U.S.) , Estados UnidosAssuntos
Envelhecimento , National Institutes of Health (U.S.) , Gravitação , Humanos , Pesquisa , Voo Espacial , Estados UnidosRESUMO
This article presents a conceptual discussion of some aspects involved in biomarkers of aging. A biomarker of aging is a biological parameter of an organism that either alone or in some multivariate composite will, in the absence of disease, better predict functional capability at some late age than will chronological age. The reasons for undertaking biomarker research, criteria for putative biomarkers, measurement and assessment of putative biomarkers, and the new initiative by the National Institute on Aging in biomarker research are discussed.
