Assuntos
Adolescente , Adulto , Feminino , Neoplasias dos Genitais Femininos/etiologia , Neoplasias dos Genitais Femininos/patologia , Neoplasias do Colo do Útero/patologia , Infecções Tumorais por Vírus/patologia , Condiloma Acuminado/etiologia , Condiloma Acuminado/diagnóstico , Papillomaviridae , ArgentinaAssuntos
Adolescente , Adulto , Feminino , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/etiologia , Neoplasias dos Genitais Femininos/etiologia , Neoplasias dos Genitais Femininos/patologia , Papillomaviridae , Infecções Tumorais por Vírus/patologia , Neoplasias do Colo do Útero/patologia , ArgentinaAssuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Neoplasias do Colo do Útero , Colo do Útero/patologia , AdenocarcinomaAssuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Adenocarcinoma , Colo do Útero/patologia , Neoplasias do Colo do ÚteroRESUMO
BACKGROUND: Human papillomavirus (HPVs) types 6 and 11, are frequently found in non-malignant anogenital condylomas and laryngeal papillomas. However, in an ongoing epidemiological study in Argentina in which 163 anogenital and aero-respiratory cancer biopsies were analyzed, several cases infected with low-risk HPVs could be detected. METHODS: Tumor samples were analyzed by Southern blot hybridization, using HPVs 6, 11, 16, 18, 30, 31, 33 and 35 as probes, and polymerase chain reaction (PCR) with type-specific primers and probes. RESULTS: Four invasive carcinomas containing HPV 6 or 11 could be detected (2.4%) by Southern blot technique. HPV 6 DNA was found in a penile carcinoma, a groin carcinoma, and in a tonsillar carcinoma. One cervical carcinoma harbored HPV 11 DNA. Using HPVs 6, 11, 16, 18 and 33 anticontamination primers and probes in PCR, no additional high-risk HPV types could be detected in these four cancers. CONCLUSION: This report shows the presence of low-risk HPVs (HPV 6 and 11) associated to malignant tumors in a frequency higher than usually observed. The data raise questions about which are the circumstances which may favor low-risk HPV related oncogenesis.