Insights on the Dynamics and Toxicity of Nanoparticles in Environmental Matrices.

The manufacturing rate of nanoparticles (10-100 nm) is steadily increasing due to their extensive applications in the fabrication of nanoproducts related to pharmaceuticals, cosmetics, medical devices, paints and pigments, energy storage etc. An increase in research related to nanotechnology is also a cause for the production and disposal of nanomaterials at the lab scale. As a result, contamination of environmental matrices with nanoparticles becomes inevitable, and the understanding of the risk of nanoecotoxicology is getting larger attention. In this context, focusing on the environmental hazards is essential. Hence, this manuscript aims to review the toxic effects of nanoparticles on soil, water, aquatic, and terrestrial organisms. The effects of toxicity on vertebrates, invertebrates, and plants and the source of exposure, environmental and biological dynamics, and the adverse effects of some nanoparticles are discussed.

Impact of yoga in facilitating muscular functioning among asymptomatic male cricket players: Longitudinal randomized controlled study.

BACKGROUND: Cricket is one of the prominent global team sports. With an emergence of Twenty20 tournaments, the physical preparation of elite cricket players has become complex with high match injury incidence. Yoga as a body-mind training is associated with having positive effects on a person's physical and psychological conditions, bringing in better mind-body equilibrium. OBJECTIVES: Evaluating the impact of yoga in facilitating muscular functioning and mindfulness among asymptomatic male cricket players. METHOD: First-class domestic male cricket players in the age group of 18-35 years were randomized into yoga group n=42 and wait-list control group n=40. Players received the yoga module for five days per week for a duration of six weeks. Primary outcome measures of muscular functioning were core stability, flexibility, range of motion, static balance, dynamic balance and proprioception of the ankle. Assessments were held at baseline, immediate post-intervention, and a follow-up after six months of intervention. RESULTS: A statistical significance with p < .001 was observed for most of the variables at T2 and T3. Comparison of the model fit shows a highly significant p < 0.001 difference between the model as compared to the baseline model among most of the variables. CONCLUSION: This yoga module was appropriate for enhancing muscular functioning variables of this study. Continuous practice of this yoga module can reinforce sustainable benefits for male cricket players.

A Comparative Study between Vedic and Contemporary Education Systems using Bio-Energy Markers.

BACKGROUND/AIM: "The destiny of the whole world depends on the children. If you want to see the silver lining on the horizon it is not you and me, but the children who have to be spiritualized" says Swami Satyananda Saraswati. Sri Aurobindo states "Education to be complete must have five principal aspects corresponding to the five principal activities of the human being: the physical, the vital, the mental, the psychic and the spiritual." Vedic education system (VES) focuses on inculcating all facets for overall development of personality. This study is an attempt to understand the lore of Vedic education followed by yoga as a way of lifestyle for physiological well-being and for successful unfoldment of children's personality. MATERIALS AND METHODS: The sample size was 378 (108 VES and 270 contemporary education system [CES]). We have excluded volunteers who had minor health problems from the study. The ethical clearance was taken from SVYASA University Ethics Committee, and informed consent was obtained for each individual undergoing the study. As it was aimed to collect one-time data, the yoga as a lifestyle in VES itself considered as an intervention. Thus, the two systems of educations are compared. The variables are measured using the Electro-photonic Image Bio-Well instrument. RESULTS: Bio-Well variables for VES and CES were compared. There was a significant difference in VES and CES energy level scores, left-right symmetry scores, organ balance, and entropy coefficient scores. CONCLUSIONS: Results suggest that Vedic Education System to be better in the measured parameters compared to Contemporary Education System.

Electrical transport and gas sensing characteristics of dielectrophoretically aligned MBE grown catalyst free InAs nanowires.

In this report, the precise alignment of catalyst free InAs nanowires (NWs) on pre-patterned Au microelectrodes by dielectrophoresis (DEP) technique for gas sensing applications is presented. The catalyst free InAs NWs have been grown on Si (111) substrate by molecular beam epitaxy (MBE) technique. The effect of dispersing solvents, electrode geometries and gaps, magnitude, frequency and duration of applied voltage etc, has been studied for aligning the InAs NWs by DEP technique. Current-voltage (I-V) measurements on the aligned NWs show linear behavior at room temperature (300 K), which changes to nonlinear at lower temperatures and higher voltages. The nonlinearity at lower temperatures and higher voltages is well explained by a space charge limited current contribution, which further gives a quantitative estimation of free charge carriers and trap density. The DEP aligned NWs exhibit good sensing response upon exposure to 10 ppm NO2 gas.

Classification of Electrophotonic Images of Yogic Practice of Mudra through Neural Networks.

BACKGROUND: Mudras signify a gesture with hands, eyes, and the body. Different configurations of the joining of fingertips are also termed mudra and are used by yoga practitioners for energy manipulation and for therapeutic applications. Electrophotonic imaging (EPI) captures the coronal discharge around the fingers as a result of electron capture from the ten fingers. The coronal discharge around each fingertip is studied to understand the effect of mudra on EPI parameters. METHODS: The participants were from Swami Vivekananda Yoga Anusandhana Samsthana and Sushrutha Ayurvedic Medical College, in Bengaluru, India. There were 29 volunteers in the mudra group and 32 in the control group. There were two designs: one was a pre-post design with control the other was pre-post with repeated measures with 18 individuals practicing mudra for 3 days. The duration of intervention for the pre-post design was 10 min on the 1st day, 15 min on the 2nd day, and 20 min on the 3rd day. A neural network classifier was used for classifying mudra and control samples. RESULTS: The EPI parameters, normalized area and average intensity, passed the test of normality Shapiro-Wilk. The Cohen's d, effect size was 0.988 and 0.974 for the mudra and control groups, respectively. Neural network-based analysis showed the classification accuracy of the post-intervention samples for mudra and control varied from 85% to 100% while the classification accuracy varied from 55% to 70% for the pre-intervention samples. The result of the mudra intervention showed statistically significant changes in the mean values on the 3rd day compared to the 1st day. CONCLUSIONS: The effect size of the variations in mudra was more than that of the control group. Mudra practice of a longer duration showed statistically significant change in the EPI parameter, average intensity in comparison to the practice on the 1st day.

Effect of Lotus Posture on Acupuncture Meridian Energies: A Controlled Trial.

BACKGROUND: Many studies have assessed Yoga practices using instruments such as AcuGraph, which measures conductances at Jing-Well points of acupuncture meridians. Such studies find that participation in Yoga programs ranging from a weekend to many months systematically increases subtle energy. Here, we report comparison of Jing-Well point conductances before and after sitting in Lotus Posture with those before and after sitting in a chair. METHODS: This was a controlled study conducted on 52 male Yoga practitioners (mean age in years 23.03 ± 3.23), all with >1 year experience of Yoga practices. Participants were alternately assigned into two groups, sitting in Lotus Posture and sitting in a chair. Each was measured on 3 successive days, before and after sitting as instructed for 10 min on the 1st day, 20 min on the 2nd day, and 30 min on the 3rd day. RESULTS: The two groups yielded completely different results: those sitting in Lotus Posture for 30 min showed increases in subtle energy levels (E_Ls) in all acupuncture meridians; those sitting in chair produced universal decreases. Results for 10 and 20 min showed how these changes in energy values took time to build up with increasing time. CONCLUSIONS: Sitting in Lotus Posture is held to strongly stimulate subtle E_Ls, so results agreed with the experimental hypothesis. Nevertheless, decreases in E_Ls of those sitting in a chair were surprising since the rest might be expected to have no effect.

Acute effects of mobile phone radiations on subtle energy levels of teenagers using electrophotonic imaging technique: A randomized controlled study.

BACKGROUND: Mobile phones induce radio frequency electromagnetic field (RF-EMF) which has been found to affect subtle energy levels of adults through Electrophotonic Imaging (EPI) technique in a previous pilot study. MATERIALS AND METHODS: We enrolled 61 healthy right-handed healthy teenagers (22 males and 39 females) in the age range of 17.40 ± 0.24 years from educational institutes in Bengaluru. Subjects were randomly divided into two groups: (1) (mobile phone in ON mode [MPON] at right ear) and (2) mobile phone in OFF mode (MPOF). Subtle energy levels of various organs of the subjects were measured using gas discharge visualization Camera Pro device, in double-blind conditions, at two points of time: (1) baseline and (2) after 15 min of MPON/MPOF exposure. As the data were found normally distributed, paired and independent samples t-test were applied to perform within and between group comparisons, respectively. RESULTS: The subtle energy levels were significantly reduced after RF-EMF exposure in MPON group as compared to MPOF group for following areas: (a) Pancreas (P = 0.001), (b) thyroid gland (P = 0.002), (c) cerebral cortex (P < 0.01), (d) cerebral vessels (P < 0.05), (e) hypophysis (P = 0.013), (f) left ear and left eye (P < 0.01), (g) liver (P < 0.05), (h) right kidney (P < 0.05), (i) spleen (P < 0.04), and (j) immune system (P < 0.02). CONCLUSION: Fifteen minutes of RF-EMF exposure exerted quantifiable effects on subtle energy levels of endocrine glands, nervous system, liver, kidney, spleen, and immune system of healthy teenagers. Future studies should try to correlate these findings with respective biochemical markers and standard radio-imaging techniques.

Diabetes Mellitus Type 2 and Yoga: Electro Photonic Imaging Perspective.

BACKGROUND: Yoga is the most popular form of alternative medicine for the management of diabetes mellitus type 2. The electro-photonic imaging (EPI) is another contribution from alternative medicine in health monitoring. AIM: To evaluate diabetes from EPI perspective. OBJECTIVES: (1) Compare various EPI parameters in normal, prediabetic and diabetic patients. (2) Find difference in controlled and uncontrolled diabetes. (3) Study the effect of 7 days diabetes-specific yoga program. MATERIALS AND METHODS: For the first objective, there were 102 patients (normal 29, prediabetic 13, diabetic 60). In the second study, there were 60 patients (controlled diabetes 27, uncontrolled diabetes 33). The third study comprised 37 patients. EPI parameters were related to general health as well to specific organs. RESULTS: In the first study, significant difference was observed between (1) Diabetics and normal: average intensity 5.978, form coefficient 3.590, immune organs 0.281 all P < 0.001; (2) Diabetics and prediabetics: average intensity 6.676, form coefficient 4.158, immune organs 5.890 P < 0.032; (3) Normal and prediabetes: immune organs (-6.171 P = 000). In the second study, remarkable difference was in the immune organs (0.201, P = 0.031). In the pre- and post-study, the mean difference was: area 630.37, form coefficient 1.78, entropy 0.03, liver 0.24, pancreas 0.17, coronary vessels 0.11, and left kidney 29, with all P < 0.02. CONCLUSION: There is a significant difference in EPI parameters between normal, prediabetics and diabetics, the prominent being average intensity, form coefficient, and immune organs. Between controlled and uncontrolled diabetes, immune organs show significant change. Intervention of yoga results in change in most parameters.

Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function.

Maspin is a non-inhibitory member of the serpin family that affects cell behaviours related to migration and survival. We have previously shown that peptides of the isolated G α-helix (G-helix) domain of maspin show bioactivity. Migration, invasion, adhesion and proliferation of vascular smooth muscle cells (VSMC) are important processes that contribute to the build-up of atherosclerotic plaques. Here we report the use of functional assays of these behaviours to investigate whether other maspin-derived peptides impact directly on VSMC; focusing on potential anti-atherogenic properties. We designed 18 new peptides from the structural moieties of maspin above ten amino acid residues in length and considered them beside the existing G-helix peptides. Of the novel peptides screened those with the sequences of maspin strand 4 and 5 of beta sheet B (S4B and S5B) reduced VSMC migration, invasion and proliferation, as well as increasing cell adhesion. A longer peptide combining these consecutive sequences showed a potentiation of responses, and a 7-mer contained all essential elements for functionality. This is the first time that these parts of maspin have been highlighted as having key roles affecting cell function. We present evidence for a mechanism whereby S4B and S5B act through ERK1/2 and AMP-activated protein kinase (AMPK) to influence VSMC responses.