[Personal experience with treatment of autoimmune thrombocytopenia using intravenous IgG]. / Nase skúsenosti s liecbou autoimúnnej trombocytopénie i.v. IgG.

An immunoglobulin preparation for i.v. administration, Ivega (Imuna) was administered to 14 patients, 0.4 g/kg on five consecutive days, but also in lower doses. In all investigated patients a rapid onset of the therapeutic effect was observed--regression of haemorrhage and in 11 a concurrent rise of thrombocytes from a mean value of 20.10(9)/l to mean values of 130.10(9)/l with a maximum between the 6th and 14th day after administration. The tolerance of treatment was satisfactory and no side-effects were observed.

[Treatment of autoimmune thrombocytopenia using intravenous immunoglobulins]. / Liecba autoimúnnej trombocytopénie i.v. imunoglobulínami.

Long-term clinical research of the i.v. administration of immunoglobulins extended therapeutic possibilities of autoimmune thrombocytopenia. The administration of large doses of i.v. immunoglobulins is an effective and safe method of treatment in particular in patients refractory to steroid treatment or where steroids are contraindicated, in patients where treatment by splenectomy was ineffective and in pregnant women and young children. By more extensive verification of the above therapeutic method it will be possible to obtain more insight into the aetiology and pathogenesis of this disease.