RESUMO
Dried gound potato sprout preparations from seven varieties produced congenital deformities in one strain of hamsters. Incidence of affected litters varied from 8 to 25%, depending on potato variety. Certain steroidal solanum and veratrum alkaloids produced similar defects. Neither peel nor tuber material was teratogenic from one of the potato varieties with highly teratogenic sprouts.
Assuntos
Alcaloides , Anormalidades Congênitas/etiologia , Verduras/toxicidade , Anormalidades Induzidas por Medicamentos/etiologia , Animais , Encéfalo/anormalidades , Doenças do Sistema Nervoso Central/etiologia , Doenças do Sistema Nervoso Central/veterinária , Cricetinae , Feminino , Idade Gestacional , Microftalmia/etiologia , Gravidez , Espinha Bífida Oculta/etiologiaRESUMO
Tubers of Solanum tuberosum L. var. Russet Burbank, Kennebec, and Targhee were stored at 95% relative humidity and at 1.7, 4.4, 5.8, 7.2 or 10 C. Rates of O(2) consumption were measured periodically by removing individual tubers from storage, excising discs of pith parenchyma tissue, and incubating the discs in a Gilson respirometer at 30 C. With all three varieties, data suggest a greater involvement of pentose phosphate metabolism with tissues from tubers stored at 1.7 C as compared to those from higher temperatures. Discs from tubers stored at 1.7 C had higher respiratory quotient values (CO(2)/O(2)), were substantially less sensitive to the inhibitory effects of iodoacetic acid, and were somewhat more sensitive to the inhibitory effects of salicylhydroxamic acid than the discs from tubers stored at higher temperatures. Using [(14)C]glucose labeled in the 1 or the 6 carbon, mean C(1) to C(6) ratios in the Gilson after 3.5 hours of aging were 4.8:1 with discs from tubers stored at 1.7 C and 2.5:1 with discs from tubers stored at 7.2 C. Prior storage history is important in metabolic studies using potato tubers.
RESUMO
Lesions of hamster fetal neuraxial tissues, characterized by multifocal and coalescent zones of hemorrhage, edema, and necrosis in the cerebral mantle, brainstem, and spinal cord, were observed in experiments designed to test the teratogenicity of potato preparations. Retrospective and prospective data indicated, however, that the potato preparations were not responsible but that the disease occurred spontaneously in the colony and was associated with direct breeding contact of virgin females with certain males. Observations suggest that an infectious agent may be responsible, but no agent was recovered. Immunofluorescence assay of inoculated cultures indicated that reovirus was not present in affected fetal tissues.
