Experimental Research of Selected Lattice Structures Developed with 3D Printing Technology.

This paper presents the results of the experimental research of 3D structures developed with an SLA additive technique using Durable Resin V2. The aim of this paper is to evaluate and compare the compression curves, deformation process and energy-absorption parameters of the topologies with different characteristics. The structures were subjected to a quasi-static axial compression test. Five different topologies of lattice structures were studied and compared. In the initial stage of the research, the geometric accuracy of the printed structures was analysed through measurement of the diameter of the beam elements at several selected locations. Compression curves and the stress history at the minimum cross-section of each topology were determined. Energy absorption parameters, including absorbed energy (AE) and specific absorbed energy (SAE), were calculated from the compression curves. Based on the analysis of the photographic material, the failure mode was analysed, and the efficiency of the topologies was compared.

Patterns of practice of adaptive re-planning for anatomic variances during cone-beam CT guided radiotherapy.

PURPOSE: Substantial, unanticipated anatomic variances during cone-beam CT (CBCT)-guided radiotherapy can potentially impact treatment accuracy and clinical outcomes. This study assessed patterns of practice of CBCT variances reported by RTTs and subsequent interventions for multiple-disease sites. METHODS: A chart review was conducted at a large cancer centre for patients treated with daily online CBCT-guided radiotherapy. Patients selected for review were identified via RTT-reported variances that then triggered offline multi-disciplinary assessment. Cases were categorized by the type of anatomic variance observed on CBCT and any further interventions recorded such as un-scheduled adaptive re-planning. RESULTS: Over a 1-year period, 287 variances from 261 patients were identified (6.2% of the 4207 patients treated with daily CBCT-guided radiotherapy), most often occurring within the first 5 fractions of the treatment course. Of these variances, 21% (59/287) were re-planned and 3.5% (10/287) discontinued treatment altogether. Lung was the most frequent disease-site (27% of 287 variances) reported with IGRT-related variances although head and neck and sarcoma were most frequently re-planned (19% of 59 re-plans for each site). Technical or clinical rationales for re-planning were not routinely documented in patient medical records. All disease-sites had numerous categories of variances. Three of the four most frequent categories were for tumor-related changes on CBCT, and the re-planning rate was highest for tumor progression at 25%. Normal tissue variances were the second most frequency category, and re-planned in 14% of those cases. CONCLUSION: RTTs identified a wide range of anatomic variances during CBCT-guided radiotherapy. In a minority of cases, these substantially altered the care plan including ad hoc adaptive re-planning or treatment discontinuation. Improved understanding of the clinical decisions in these cases would aid in developing more routine, systematic adaptive strategies.